Abstract:
:Solvent-free, nonvolatile, room-temperature alkylated-π functional molecular liquids (FMLs) are rapidly emerging as a new generation of fluid matter. However, precision design to tune their physicochemical properties remains a serious challenge because the properties are governed by subtle π-π interactions among functional π-units, which are very hard to control and characterize. Herein, we address the issue by probing π-π interactions with highly sensitive pyrene-fluorescence. A series of alkylated pyrene FMLs were synthesized. The photophysical properties were artfully engineered with rational modulation of the number, length, and substituent motif of alkyl chains attached to the pyrene unit. The different emission from the excimer to uncommon intermediate to the monomer scaled the pyrene-pyrene interactions in a clear trend, from stronger to weaker to negligible. Synchronously, the physical nature of these FMLs was regulated from inhomogeneous to isotropic. The inhomogeneity, unexplored before, was thoroughly investigated by ultrafast time-resolved spectroscopy techniques. The result provides a clearer image of liquid matter. Our methodology demonstrates a potential to unambiguously determine local molecular organizations of amorphous materials, which cannot be achieved by conventional structural analysis. Therefore this study provides a guide to design alkylated-π FMLs with tailorable physicochemical properties.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lu F,Takaya T,Iwata K,Kawamura I,Saeki A,Ishii M,Nagura K,Nakanishi Tdoi
10.1038/s41598-017-03584-1subject
Has Abstractpub_date
2017-06-13 00:00:00pages
3416issue
1issn
2045-2322pii
10.1038/s41598-017-03584-1journal_volume
7pub_type
杂志文章abstract::Advances in microfluidics technology has enabled many discoveries on microbial mechanisms and phenotypes owing to its exquisite controls over biological and chemical environments. However, emulating accurate ecologically relevant flow environments (e.g. microbes around a rising oil droplet) in microfluidics remains ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50153-9
更新日期:2019-09-24 00:00:00
abstract::Long-term monitoring of host-parasite interactions is important for understanding the consequences of infection on host fitness and population dynamics. In an eight-year survey of the loggerhead sea turtle (Caretta caretta) population nesting in Cabo Verde, we determined the spatiotemporal variation of Ozobranchus mar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75498-4
更新日期:2020-10-29 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-018-20356-7
更新日期:2018-02-02 00:00:00
abstract::This corrects the article DOI: 10.1038/srep16188. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46909
更新日期:2017-12-22 00:00:00
abstract::Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We inves...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16391-5
更新日期:2017-11-24 00:00:00
abstract::Extracellular matrix (ECM) mechanical properties upregulate cancer invasion, cell contractility, and focal adhesion formation. Alteration in energy metabolism is a known characteristic of cancer cells (i.e., Warburg effect) and modulates cell invasion. There is little evidence to show if collagen density can alter can...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35381-9
更新日期:2018-11-20 00:00:00
abstract::The aim of this study was to investigate left ventricular (LV) global myocardial strain and LV involvement characteristics in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and to evaluate their predictive value of adverse cardiac events. Sixty consecutive ARVD/C patients with a defin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50535-z
更新日期:2019-10-02 00:00:00
abstract::Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61970-8
更新日期:2020-03-20 00:00:00
abstract::Although graphene is a typical two dimensional materials, it has converted to multi-dimensional materials with many unique properties. As an example, the one dimensional graphene fiber is fabricated by utilizing ionic liquid as coagulation and functional diamines as cross-linkers to connect graphene oxide layers. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29534
更新日期:2016-07-08 00:00:00
abstract::The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we investigated the role...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42279
更新日期:2017-02-10 00:00:00
abstract::While there is a rich literature on transcription dynamics during the development of many organisms, protein data is limited. We used iTRAQ isotopic labeling and mass spectrometry to generate the largest developmental proteomic dataset for any animal. Expression dynamics of nearly 4,000 proteins of Xenopus laevis was ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04365
更新日期:2014-03-14 00:00:00
abstract::Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38259-y
更新日期:2019-02-28 00:00:00
abstract::Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07779-4
更新日期:2017-08-02 00:00:00
abstract::The modifier protein, ubiquitin (Ub) regulates various cellular pathways by controlling the fate of substrates to which it is conjugated. Ub moieties are also conjugated to each other, forming chains of various topologies. In cells, poly-Ub is attached to proteins and also exists in unanchored form. Accumulation of un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26364-x
更新日期:2018-05-31 00:00:00
abstract::Stable electroluminescence from micro-pixelated light-emitting diode (μLED) occurs when electrons and holes are continuously injected from external electrodes. Different from the general recognition, in this work, μLED works in an operation mode, namely, non-electrical contact and non-carrier injection mode, and can b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65092-z
更新日期:2020-05-15 00:00:00
abstract::We report the impact of anti-urothelial autoantibody (AUAb) on urinary bladder phenotype in BALB/c mice deficient of the FcγRIIb and PD-1. AUAb was present in serum samples from approximately half of the double-knockout (DKO) mice, as detected by immunofluorescence and immunoblots for urothelial proteins including uro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00317
更新日期:2012-01-01 00:00:00
abstract::Oceanic physics at fine scale; e.g. eddies, fronts, filaments; are notoriously difficult to sample. However, an increasing number of theoretical approaches hypothesize that these processes affect phytoplankton diversity which have cascading effects on regional ecosystems. In 2015, we targeted the Iroise Sea (France) a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82071-0
更新日期:2021-01-29 00:00:00
abstract::We investigated the effect of a new Rho kinase inhibitor, SB772077B (SB77) on aqueous outflow facility (OF) in human eyes using human organ-cultured anterior segment (HOCAS). IOP was monitored for 24 h post-treatment with either SB77 (0.1/10/50 µM) or vehicle after a stable baseline pressure. The hydrodynamic pattern ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33932-8
更新日期:2018-10-19 00:00:00
abstract::The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35888-1
更新日期:2018-11-26 00:00:00
abstract::The combustion of candles exhibits a variety of dynamical behaviors. Binding several candles together will result in flickering of candle flames, which is generally described as a nonlinear oscillator. The impact on the frequency of the flame by several factors, such as the arrangement, the number and the asymmetry of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36754-w
更新日期:2019-01-23 00:00:00
abstract::Although an increasing interest in vision training for sport performance, whether it may have a transfer to sport-specific skills and whether such transfer could be mediated by cognition remain open issues. To enlighten this point, we tested the effect of 6-weeks sport vision training programmes (requiring generic or ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-55252-1
更新日期:2019-12-10 00:00:00
abstract::Herein, we propose an advanced energy-storage system: all-graphene-battery. It operates based on fast surface-reactions in both electrodes, thus delivering a remarkably high power density of 6,450 W kg(-1)(total electrode) while also retaining a high energy density of 225 Wh kg(-1)(total electrode), which is comparabl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05278
更新日期:2014-06-13 00:00:00
abstract::The Near-infrared Fluorescence (NIRF) molecular imaging of cancer is known to be superior in sensitivity, deeper penetration, and low phototoxicity compared to other imaging modalities. In view of an increased need for efficient and targeted imaging agents, we synthesized a NAD(P)H quinone oxidoreductase 1 (NQO1)-acti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44111-8
更新日期:2019-06-12 00:00:00
abstract::Recent paleoclimatic studies suggest that changes in the tropical rainbelt across the Atlantic Ocean during the past two millennia are linked to a latitudinal shift of the Intertropical Convergence Zone (ITCZ) driven by the Northern Hemisphere (NH) climate. However, little is known regarding other potential drivers th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38003-6
更新日期:2019-02-08 00:00:00
abstract::Acoustic manipulation by an ultrasonic phased array provides an entirely new approach to processes such as coalescence, mixing, separation, and evaporation occurring in the generation of new materials, physical property measurement, the biomedical industry, etc. However, to date, ultrasonic phased arrays have not been...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28451-5
更新日期:2018-07-05 00:00:00
abstract::Acute heart failure (AHF) emerges either de novo or from worsening of chronic heart failure (CHF). The aim of the present study was to evaluate the association between worsening of CHF and mortality in AHF patients. Out of 152 included AHF patients, 47 (30.9%) were de novo AHF patients and 105 (69%) were AHF patients ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28027-3
更新日期:2018-06-25 00:00:00
abstract::The local flexibility of an enzyme's active center plays pivotal roles in catalysis, however, little is known about how the flexibility of these flexible residues affects stability. In this study, we proposed an active center stabilization (ACS) strategy to improve the kinetic thermostability of Candida rugosa lipase1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33797
更新日期:2016-09-26 00:00:00
abstract::Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and Epi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79666-4
更新日期:2021-01-14 00:00:00
abstract::Innate immunity is induced when pathogen-associated molecular patterns (PAMPs) bind host pattern recognition receptors (PRRs). Polyinosinic:polycytidylic acid [poly(I:C)] is a synthetic analogue of viral dsRNA that acts as a PAMP, inducing type I interferons (IFNs) in vertebrates. In the present study, the immunostimu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49931-2
更新日期:2019-09-20 00:00:00
abstract::One mechanism of action for the anticaries effect of topical fluoridation is through precipitation of CaF2. In this in vitro study energy-dispersive x-ray spectroscopy (EDX) is used as a semiquantitative method to detect enamel fluoride-precipitation under the influence of acidic and neutral pH-value and absence or pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49742-5
更新日期:2019-09-17 00:00:00