Abstract：
:There is a significant need to develop antibacterial materials that could be applied locally and directly to the places surrounded by large amount of bacteria, in order to address the problems of bacterial antibiotic-resistance or irreversible biofilm formation. Hydrogels are thought to be suitable candidates due to their versatile applications in biomedical field. Among them, small molecular hydrogels have been paid lots of attention because they are easy to design and fabricate and often sensitive to external stimuli. Meanwhile, the antibacterial activity of metal ions are attracting more and more attention because resistance to them are not yet found within bacteria. We therefore designed the zinc ion binding peptide of Nap-GFFYGGGHGRGD, who can self-assemble into hydrogels after binds Zn(2+) and inhibit the growth of bacteria due to the excellent antibacterial activity of Zn(2+). Upon the addition of zinc ions, solutions containing Nap-GFFYGGGHGRGD transformed into supramolecular hydrogels composed of network of long nano-fibers. Bacterial tests revealed an antibacterial effect of the zinc triggered hydrogels on E. coli. The studied small molecular hydrogel shows great potential in locally addressing bacterial infections.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu C,Cai Y,Ren C,Gao J,Hao Jdoi
10.1038/srep07753subject
Has Abstractpub_date
2015-01-13 00:00:00pages
7753issn
2045-2322pii
srep07753journal_volume
5pub_type
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-12-16 00:00:00
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更新日期：2016-06-13 00:00:00
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pub_type： 杂志文章
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更新日期：2018-03-15 00:00:00
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journal_title：Scientific reports
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更新日期：2016-04-26 00:00:00
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journal_title：Scientific reports
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更新日期：2016-06-09 00:00:00
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更新日期：2016-03-03 00:00:00
