Abstract：
:This study aimed to investigate whether interleukin-34 (IL-34) mRNA expression is aberrant and modulated by tumor necrosis factor-alpha (TNF-α) in knee osteoarthritis (OA) fibroblast-like synoviocytes (FLS) and determine associations of IL-34 mRNA and protein in the systemic and local joint environments with severity of knee OA synovitis. Transcriptional and translational IL-34 levels in FLS, synovium, synovial fluid, and plasma of knee OA were determined using real-time polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay. Relative mRNA expressions of NF-κB signaling molecules were further measured. In knee OA FLS stimulated with TNF-α, IL-34 mRNA expression was significantly up-regulated in a time-dependent manner. In knee OA synovium with severe synovitis, increased IL-34 mRNA expression was directly associated with IL-6, IκB, NF-κB, and MMP-13, in addition to knee OA FLS. Immunostaining score of IL-34 was considerably greater in knee OA synovium with severe synovitis than that in those with mild and no synovitis. Increments in joint fluid and plasma IL-34 levels in knee OA patients with severe synovitis were closely related to its mRNA and protein expressions in knee OA synovium. Transcriptional and translational expressions of IL-34 were positively correlated with synovitis severity. Collectively, IL-34 overexpression would reflect synovitis severity in knee OA.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Udomsinprasert W,Jinawath A,Teerawattanapong N,Honsawek Sdoi
10.1038/s41598-020-64932-2subject
Has Abstractpub_date
2020-05-14 00:00:00pages
7987issue
1issn
2045-2322pii
10.1038/s41598-020-64932-2journal_volume
10pub_type
杂志文章abstract：:HIV-1 Tat protein is released from HIV-1-infected cells and can enter non-permissive cells including neurons. Tat disrupts neuronal homeostasis and may contribute to the neuropathogenesis in people living with HIV (PLWH). The use of cocaine by PLWH exacerbates neuronal dysfunction. Here, we examined the mechanisms by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34539-9
更新日期：2018-11-02 00:00:00
abstract：:The control of structural and chemical transitions in bimetallic nanoalloys at finite temperatures is one of the challenges for their use in advanced applications. Comparing Nested Sampling and Molecular Dynamics simulations, we investigate the phase changes of CuPt nanoalloys with the aim to elucidate the role of kin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27308-1
更新日期：2018-06-14 00:00:00
abstract：:The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertili...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16563-3
更新日期：2017-11-24 00:00:00
abstract：:Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35047
更新日期：2016-10-19 00:00:00
abstract：:The networks of predator-prey interactions in ecological systems are remarkably complex, but nevertheless surprisingly stable in terms of long term persistence of the system as a whole. In order to understand the mechanism driving the complexity and stability of such food webs, we developed an eco-evolutionary model i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10955
更新日期：2015-06-04 00:00:00
abstract：:Fear is an adaptive emotion that elicits defensive behavioural responses against aversive threats in animals. In mammals, serotonin receptors (5-HTRs) have been shown to modulate fear-related neural circuits in the basolateral amygdala complex (BLA). To understand the phylogenetic continuity of the neural basis for fe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78247-9
更新日期：2020-12-03 00:00:00
abstract：:Hungarians who live in Central Europe today are one of the westernmost Uralic speakers. Despite of the proposed Volga-Ural/West Siberian roots of the Hungarian language, the present-day Hungarian gene pool is highly similar to that of the surrounding Indo-European speaking populations. However, a limited portion of sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44272-6
更新日期：2019-05-24 00:00:00
abstract：:Detailed characterization and mapping of oligonucleotide function in vivo is generally a very time consuming effort that only allows for hypothesis driven subsampling of the full sequence to be analysed. Recent advances in deep sequencing together with highly efficient parallel oligonucleotide synthesis and cloning te...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37563
更新日期：2016-11-22 00:00:00
abstract：:Steering magnetism by electric fields upon interfacing ferromagnetic (FM) and ferroelectric (FE) materials to achieve an emergent multiferroic response bears a great potential for nano-scale devices with novel functionalities. FM/FE heterostructures allow, for instance, the electrical manipulation of magnetic anisotro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11111
更新日期：2015-06-09 00:00:00
abstract：:Acclimation and adaptation, which are key to species survival in a changing climate, can be observed in terms of membrane lipid composition. Remodelling membrane lipids, via homeoviscous adaptation (HVA), counteracts membrane dysfunction due to temperature in poikilotherms. In order to assess the potential for acclima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35669
更新日期：2016-10-20 00:00:00
abstract：:Successful recruitment of new individuals is essential for recovery of degraded coral reefs. Enhancing supply of coral larvae increases initial settlement, however post-settlement survival can be influenced by density-dependent processes. We investigated the influence of larval density on settlement, colony abundance ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62366-4
更新日期：2020-03-26 00:00:00
abstract：:Late endothelial progenitor cells (LEPCs) are derived from mononuclear cells (MNCs) and are thought to directly incorporate into blood vessels and differentiate into mature endothelial cells (ECs). Using transcriptome and proteome analysis, we identified distinctive LEPC profiles and found that Hedgehog-interacting pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12571-5
更新日期：2017-09-29 00:00:00
abstract：:Creating and maintaining precipitates coherent with the host matrix, under service conditions is one of the most effective approaches for successful development of alloys for high temperature applications; prominent examples include Ni- and Co-based superalloys and Al alloys. While ferritic alloys are among the most i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11772
更新日期：2015-07-02 00:00:00
abstract：:College students, as a large part of young adults, are a vulnerable group to several risky behaviors including smoking and drug abuse. This study aimed to utilize and to compare count regression models to identify correlates of cigarette smoking among college students. This was a cross-sectional study conducted on stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65813-4
更新日期：2020-06-01 00:00:00
abstract：:Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive f...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-12027-w
更新日期：2017-09-19 00:00:00
abstract：:HIV-1 env sequencing enables predictions of viral coreceptor tropism and phylogenetic investigations of transmission events. The aim of the study was to estimate the contribution of non-R5 strains to the viral spread in Poland. Partial proviral env sequences were retrieved from baseline blood samples of patients with ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41407-7
更新日期：2019-03-21 00:00:00
abstract：:Currently little is known about structure-function mappings in the human subcortex. Here we present a large-scale automated meta-analysis on the literature to understand the structure-function mapping in the human subcortex. The results provide converging evidence into unique large scale structure-function mappings of...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-33796-y
更新日期：2018-10-26 00:00:00
abstract：:Caveolins are essential structural proteins driving the formation of caveolae, specialized invaginations of the plasma membrane. Loss of Caveolin-1 (Cav1) function in mice causes distinct neurological phenotypes leading to impaired motor control, however, the underlying developmental mechanisms are largely unknown. In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73429-x
更新日期：2020-10-05 00:00:00
abstract：:It well-known that mental training improves skill performance. Here, we evaluated skill acquisition and consolidation after physical or motor imagery practice, by means of an arm pointing task requiring speed-accuracy trade-off. In the main experiment, we showed a significant enhancement of skill after both practices ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81994-y
更新日期：2021-01-27 00:00:00
abstract：:Deregulated IGF-1R-AKT signaling influences multiple nodes of cancer cell physiology and assists in migration, metastasis and acquirement of radio/chemoresistance. Enrichment of cancer stem cells (CSC) positively correlates with radio/chemoresistance development in various malignancies. It is unclear though, how IGF-1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36612
更新日期：2016-11-07 00:00:00
abstract：:Here we describe a new instrument (SpiderMass) designed for in vivo and real-time analysis. In this instrument ion production is performed remotely from the MS instrument and the generated ions are transported in real-time to the MS analyzer. Ion production is promoted by Resonant Infrared Laser Ablation (RIR-LA) base...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25919
更新日期：2016-05-18 00:00:00
abstract：:The melting of glaciers and ice sheets is nowadays considered a symbol of climate change. Many complex mechanisms are involved in the melting of ice, and, among these processes, surface darkening due to organic material on bare ice has recently received attention from the scientific community. The presence of microbes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61762-0
更新日期：2020-03-16 00:00:00
abstract：:Peritrichs are a major group of ciliates with worldwide distribution. Yet, its internal phylogeny remains unresolved owing to limited sampling. Additionally, ecological distributions of peritrichs are poorly known. We performed substantially expanded phylogenetic analyses of peritrichs that incorporated SSU rDNA seque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21695
更新日期：2016-02-16 00:00:00
abstract：:The evolution of cooperation requires some mechanism that reduces the risk of exploitation for cooperative individuals. Recent studies have shown that men with wide faces are anti-social, and they are perceived that way by others. This suggests that people could use facial width to identify anti-social men and thus li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01047
更新日期：2013-01-01 00:00:00
abstract：:Despite strengthened antimicrobial therapy, biofilm infections of Acinetobacter baumannii are associated with poor prognosis and limited therapeutic options. Assessing antibiotics on planktonic bacteria can result in failure against biofilm infections. Currently, antibiotics to treat biofilm infections are administere...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42353-0
更新日期：2019-04-19 00:00:00
abstract：:In this paper, the effects of random errors on the oscillating behaviors have been studied theoretically and numerically in a prototypical coupled nonlinear oscillator. Two kinds of noises have been employed respectively to represent the measurement errors accompanied with the parameter specifying the distance from a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42715
更新日期：2017-02-15 00:00:00
abstract：:Odorant binding proteins (OBPs) play critical roles in chemical communication of insects, as they recognize and transport environmental chemical signals to receptors. The diving beetle Cybister japonicus Sharp shows a remarkable sexual dimorphism. The foreleg tarsi of males are equipped with large suction cups, believ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31848
更新日期：2016-08-22 00:00:00
abstract：:Prosthesis embodiment, the perception of a prosthesis as part of one's body, may be an important component of functional recovery for individuals with upper limb absence. This work determined whether embodiment differs between body-powered and myoelectric prosthesis users. In a sample of nine individuals with transrad...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72470-0
更新日期：2020-09-22 00:00:00
abstract：:In crystalline metals at small scales, the dislocation density will be increased by stochastic events of dislocation network, leading to a universal power law for various material structures. In this work, we develop a model obeyed by a probability distribution of dislocation density to describe the dislocation format...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39242
更新日期：2016-12-15 00:00:00
abstract：:Soil-transmitted nematodes (STNs), namely hookworms, whipworms, and ascarids, are extremely common parasites, infecting 1-2 billion of the poorest people worldwide. Two benzimidazoles, albendazole and mebendazole, are currently used in STN mass drug administration, with many instances of low/reduced activity reported....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48720-1
更新日期：2019-08-26 00:00:00
