An active IGF-1R-AKT signaling imparts functional heterogeneity in ovarian CSC population.

abstract：:TiNb6O17 and TiNb2O7 were synthesized using a solid-state method. The techniques were used to assess the electrochemical performance and lithium diffusion kinetics of TiNb6O17 related to the unit cell volume with TiNb2O7. The charge-discharge curves and cyclic voltammetry revealed TiNb6O17 to have a similar redox pote...

journal_title：Scientific reports

authors： Lee YS,Ryu KS

更新日期：2017-11-30 00:00:00

abstract：:Recurrence risk stratification of patients undergoing primary surgical resection for hepatocellular carcinoma (HCC) is an area of active investigation, and several staging systems have been proposed to optimize treatment strategies. However, as many as 70% of patients still experience tumor recurrence at 5 years post-...

journal_title：Scientific reports

authors： Yamashita R,Long J,Saleem A,Rubin DL,Shen J

更新日期：2021-01-21 00:00:00

abstract：:This study aimed to determine the performance and long-term outcomes of therapeutic ERCP in very old patients. Patients aged or over 90 (Group A, n = 78) and consecutive sex-matched controls (Group B, n = 312) under 65 selected were compared. More patients in Group A had chronic concomitant diseases, but the success a...

journal_title：Scientific reports

authors： Hu L,Sun X,Hao J,Xie T,Liu M,Xin L,Sun T,Liu M,Zou W,Ye B,Liu F,Wang D,Cao N,Liao Z,Li Z

更新日期：2014-05-13 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Choi S,Rogers DJ,Sandana EV,Bove P,Teherani FH,Nenstiel C,Hoffmann A,McClintock R,Razeghi M,Look D,Gentle A,Phillips MR,Ton-That C

更新日期：2017-11-16 00:00:00

abstract：:The ejection of internal organs, i.e., evisceration, is a well-known phenomenon in sea-cucumbers. We report the ability of a member of the Chordate phyla, the tropical ascidian Polycarpa mytiligera, to eviscerate and regenerate its gut within 12 days, and to rebuild its branchial sac within 19 days. Evisceration occur...

journal_title：Scientific reports

authors： Shenkar N,Gordon T

更新日期：2015-04-16 00:00:00

abstract：:The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function. However, whether and how they may serve as predictor/pro-diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversi...

journal_title：Scientific reports

authors： Zhang Y,Liu C,Liu J,Guo R,Yan Z,Liu W,Lau WB,Jiao X,Cao J,Xu K,Jia Y,Ma X,Wang Y

更新日期：2020-01-21 00:00:00

abstract：:The identification of enhancer-target gene (ETG) pairs is vital for the understanding of gene transcriptional regulation. Experimental approaches such as Hi-C have generated valuable resources of ETG pairs. Several computational methods have also been developed to successfully predict ETG interactions. Despite these p...

journal_title：Scientific reports

authors： Zhao C,Li X,Hu H

更新日期：2016-07-20 00:00:00

abstract：:Baited remote underwater video cameras were deployed in the Eastern Canadian Arctic, for the purpose of estimating local densities of the long-lived Greenland shark within five deep-water, data-poor regions of interest for fisheries development and marine conservation in Nunavut, Canada. A total of 31 camera deploymen...

journal_title：Scientific reports

authors： Devine BM,Wheeland LJ,Fisher JAD

更新日期：2018-01-17 00:00:00

abstract：:Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell type-specific functions. In these two cell types, mCpHs show distinct motifs and correlations to transcription that could be a key in understanding the cell type-sp...

journal_title：Scientific reports

authors： Lee JH,Park SJ,Nakai K

更新日期：2017-09-12 00:00:00

abstract：:While safety of fasting therapy is debated in humans, extended fasting occurs routinely and safely in wild animals. To do so, food deprived animals like breeding penguins anticipate the critical limit of fasting by resuming feeding. To date, however, no molecular indices of the physiological state that links spontaneo...

journal_title：Scientific reports

authors： Bertile F,Fouillen L,Wasselin T,Maes P,Le Maho Y,Van Dorsselaer A,Raclot T

更新日期：2016-12-19 00:00:00

abstract：:Cortical spreading depolarisation (CSD), the neural mechanism underlying migraine aura, may cause headache by sensitising the trigeminal system. Photophobia, the most bothersome accompanying symptom during migraine attacks, is more prevalent in migraine with aura than in migraine without aura. Whether CSD plays a role...

journal_title：Scientific reports

authors： Tang C,Unekawa M,Kitagawa S,Takizawa T,Kayama Y,Nakahara J,Shibata M

更新日期：2020-07-10 00:00:00

abstract：:We study the electronic structure and lattice dynamics in the ferromagnet MnBi using first-principles calculations and a tight-binding model. The band structure around the Fermi level is dominated by Bi-p states which are the primary contributors to the magnetic anisotropy energy in the low temperature structure. A ti...

journal_title：Scientific reports

authors： Shanavas KV,Parker D,Singh DJ

更新日期：2014-11-27 00:00:00

abstract：:The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. Infusion of a non-hy...

journal_title：Scientific reports

authors： Yang C,Larin A,McKenna JT,Jacobson KA,Winston S,Strecker RE,Kalinchuk A,Basheer R,Brown RE

更新日期：2018-07-16 00:00:00

abstract：:Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to "tailor-make" specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-positive breast cance...

journal_title：Scientific reports

authors： Eswaran J,Horvath A,Godbole S,Reddy SD,Mudvari P,Ohshiro K,Cyanam D,Nair S,Fuqua SA,Polyak K,Florea LD,Kumar R

更新日期：2013-01-01 00:00:00

abstract：:To evaluate the association between vision-related quality of life (QoL), physical inactivity, and locomotor dysfunction in subjects with visual impairment.This cross-sectional study included 215 visually impaired subjects recruited from six ophthalmology departments in Japan. The physical inactivity and locomotor dys...

journal_title：Scientific reports

authors： Inoue S,Kawashima M,Hiratsuka Y,Nakano T,Tamura H,Ono K,Murakami A,Tsubota K,Yamada M

更新日期：2018-08-13 00:00:00

abstract：:Thiamine monophosphate kinase (ThiL) catalyzes the last step of thiamine pyrophosphate (TPP) synthesis, the ATP-dependent phosphorylation of thiamine monophosphate (TMP) to thiamine pyrophosphate. We solved the structure of ThiL from the human pathogen A. baumanii in complex with a pair of substrates TMP and a non-hyd...

journal_title：Scientific reports

authors： Sullivan AH,Dranow DM,Horanyi PS,Lorimer DD,Edwards TE,Abendroth J

更新日期：2019-03-13 00:00:00

abstract：:We describe a new reproducibility-optimization method ROPECA for statistical analysis of proteomics data with a specific focus on the emerging data-independent acquisition (DIA) mass spectrometry technology. ROPECA optimizes the reproducibility of statistical testing on peptide-level and aggregates the peptide-level c...

journal_title：Scientific reports

authors： Suomi T,Elo LL

更新日期：2017-07-19 00:00:00

abstract：:Based on the pro-drug principle, aspirin and eugenol were used to synthesize aspirin eugenol ester (AEE) by esterification reaction. In present study, the anti-atherosclerosis effects of AEE were investigated in hamsters with the utilization of metabonomic approach based on UPLC-Q-TOF/MS. Biochemical parameters and hi...

journal_title：Scientific reports

authors： Ma N,Yang Y,Liu X,Kong X,Li S,Qin Z,Jiao Z,Li J

更新日期：2017-09-05 00:00:00

abstract：:In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...

journal_title：Scientific reports

authors： Diao Y,Chen B,Wei L,Wang Z

更新日期：2018-08-24 00:00:00

abstract：:To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide new knowledge in neuroscience and contribute to regenerative medical techniques and prosthetics care. An application that combines optogenetic...

journal_title：Scientific reports

authors： Kobayashi T,Haruta M,Sasagawa K,Matsumata M,Eizumi K,Kitsumoto C,Motoyama M,Maezawa Y,Ohta Y,Noda T,Tokuda T,Ishikawa Y,Ohta J

更新日期：2016-02-16 00:00:00

abstract：:Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors. Progesterone affects cell proliferation and survival via non-genomic effects. In ...

journal_title：Scientific reports

authors： Kasubuchi M,Watanabe K,Hirano K,Inoue D,Li X,Terasawa K,Konishi M,Itoh N,Kimura I

更新日期：2017-07-12 00:00:00

abstract：:Each year, droughts cause significant economic and agricultural losses across the world. The early warning and onset detection of drought is of particular importance for effective agriculture and water resource management. Previous studies show that the Standard Precipitation Index (SPI), a measure of precipitation de...

journal_title：Scientific reports

authors： Farahmand A,AghaKouchak A,Teixeira J

更新日期：2015-02-25 00:00:00

abstract：:This study is the first report on the preparation of mesoporous carbon/silica (MCS) nanocomposites with tunable mesoporosity and hydrophobicity using natural rubber (NR) as a renewable and cheap carbon source. A series of mesoporous nanocomposites based on NR and hexagonal mesoporous silica (HMS) were prepared via an ...

journal_title：Scientific reports

authors： Yousatit S,Pitayachinchot H,Wijitrat A,Chaowamalee S,Nuntang S,Soontaranon S,Rugmai S,Yokoi T,Ngamcharussrivichai C

更新日期：2020-07-31 00:00:00

abstract：:ADC is a potential post treatment imaging biomarker in colorectal liver metastasis however measurements are affected by respiratory motion. This is compounded by increased statistical uncertainty in ADC measurement with decreasing tumour volume. In this prospective study we applied a retrospective motion correction me...

journal_title：Scientific reports

authors： Pathak R,Tian J,Thacker NA,Morris DM,Ragheb H,Saunders C,Saunders M,Jackson A

更新日期：2019-03-07 00:00:00

abstract：:Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...

journal_title：Scientific reports

authors： Inserra A,Choo JM,Lewis MD,Rogers GB,Wong ML,Licinio J

更新日期：2019-04-23 00:00:00

abstract：:The genetics underlying autism spectrum disorder (ASD) are complex. Approximately 3-5% of ASD cases arise from maternally inherited duplications of 15q11.2-q13.1, termed Duplication 15q syndrome (Dup15q). 15q11.2-q13.1 includes the gene UBE3A which is believed to underlie ASD observed in Dup15q syndrome. UBE3A is an E...

journal_title：Scientific reports

authors： Hope KA,McGinn A,Reiter LT

更新日期：2019-02-20 00:00:00

abstract：:Ionotropic glutamate receptors (iGluRs) are responsible for most of the fast excitatory communication between neurons in our brain. The GluD2 receptor is a puzzling member of the iGluR family: It is involved in synaptic plasticity, plays a role in human diseases, e.g. ataxia, binds glycine and D-serine with low affini...

journal_title：Scientific reports

authors： Tapken D,Steffensen TB,Leth R,Kristensen LB,Gerbola A,Gajhede M,Jørgensen FS,Olsen L,Kastrup JS

更新日期：2017-04-07 00:00:00

abstract：:Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell lines when maintained in vitro. Culture conditions and long-term culture have been traditionally proposed as possible factors involved in the...

journal_title：Scientific reports

authors： Gaztelumendi N,Nogués C

更新日期：2014-06-17 00:00:00

abstract：:Because of their exceptional local-field enhancement and ultrasmall mode volume, plasmonic components can integrate photonics and electronics at nanoscale, and active control of plasmons is the key. However, all-optical modulation of plasmonic response with nanometer mode volume and unity modulation depth is still lac...

journal_title：Scientific reports

authors： Wu HY,Huang YT,Shen PT,Lee H,Oketani R,Yonemaru Y,Yamanaka M,Shoji S,Lin KH,Chang CW,Kawata S,Fujita K,Chu SW

更新日期：2016-04-11 00:00:00

abstract：:The cortisol stress response and the molecular programming of the corticoid axis were characterized for the first time during early ontogeny in a Mediterranean marine teleost, the European sea bass (Dicentrarchus labrax). Sea bass embryos, pre-larvae and larvae at specific points of development were exposed to acute s...

journal_title：Scientific reports

authors： Tsalafouta A,Papandroulakis N,Gorissen M,Katharios P,Flik G,Pavlidis M

更新日期：2014-07-02 00:00:00