In vivo Real-Time Mass Spectrometry for Guided Surgery Application.

abstract：:Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as shown by the increase i...

journal_title：Scientific reports

authors： Sapili H,Ho CS,Malagobadan S,Arshad NM,Nagoor NH

更新日期：2020-01-22 00:00:00

abstract：:Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...

journal_title：Scientific reports

authors： Hagag IT,Wight DJ,Bartsch D,Sid H,Jordan I,Bertzbach LD,Schusser B,Kaufer BB

更新日期：2020-07-02 00:00:00

abstract：:Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids (conjugation) requires the close proximity of cells. HGT between genetically distinct bacteria largely depends on cell movement in water films, w...

journal_title：Scientific reports

authors： Berthold T,Centler F,Hübschmann T,Remer R,Thullner M,Harms H,Wick LY

更新日期：2016-11-04 00:00:00

abstract：:The global incidence of obesity has led to an increasing need for understanding the molecular mechanisms that drive this epidemic and its comorbidities. Quantitative real-time RT-PCR (RT-qPCR) is the most reliable and widely used method for gene expression analysis. The selection of suitable reference genes (RGs) is c...

journal_title：Scientific reports

authors： Perez LJ,Rios L,Trivedi P,D'Souza K,Cowie A,Nzirorera C,Webster D,Brunt K,Legare JF,Hassan A,Kienesberger PC,Pulinilkunnil T

更新日期：2017-06-15 00:00:00

abstract：:For the past 30 years, oocytes from Xenopus laevis have been extensively used to express and characterise ion channels in an easily controlled environment. Here we report the first use of oocytes from the closely related species Xenopus borealis as an alternative expression system for neuronal ion channels. Using the ...

journal_title：Scientific reports

authors： Cristofori-Armstrong B,Soh MS,Talwar S,Brown DL,Griffin JD,Dekan Z,Stow JL,King GF,Lynch JW,Rash LD

更新日期：2015-10-06 00:00:00

abstract：:Balance is a very important function that allows maintaining a stable stance needed for many daily life activities and for preventing falls. We investigated whether balance control could be improved by a placebo procedure consisting of verbal suggestion. Thirty healthy volunteers were randomized in two groups (placebo...

journal_title：Scientific reports

authors： Villa-Sánchez B,Emadi Andani M,Menegaldo G,Tinazzi M,Fiorio M

更新日期：2019-04-23 00:00:00

abstract：:Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), ...

journal_title：Scientific reports

authors： van de Wijgert JHHM,Verwijs MC,Agaba SK,Bronowski C,Mwambarangwe L,Uwineza M,Lievens E,Nivoliez A,Ravel J,Darby AC

更新日期：2020-03-03 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients i...

journal_title：Scientific reports

authors： Salas A,Pardo-Seco J,Cebey-López M,Gómez-Carballa A,Obando-Pacheco P,Rivero-Calle I,Currás-Tuala MJ,Amigo J,Gómez-Rial J,Martinón-Torres F,GENDRES network.

更新日期：2017-11-21 00:00:00

abstract：:In applications involving large tissue specimens that have been sectioned into smaller tissue fragments, manual reconstruction of a "pseudo whole-mount" histological section (PWMHS) can facilitate (a) pathological disease annotation, and (b) image registration and correlation with radiological images. We have previous...

journal_title：Scientific reports

authors： Penzias G,Janowczyk A,Singanamalli A,Rusu M,Shih N,Feldman M,Stricker PD,Delprado W,Tiwari S,Böhm M,Haynes AM,Ponsky L,Viswanath S,Madabhushi A

更新日期：2016-07-26 00:00:00

abstract：:Alterations of carbohydrate structures in cancer cells are the most promising targets for developing clinical diagnostic reagents. Pancreatic cancer is one of the most difficult cancers to diagnose because it lacks definitive symptoms. Two antibodies were raised against human pancreatic ribonuclease 1 that bind to the...

journal_title：Scientific reports

authors： Nakata D

更新日期：2014-10-22 00:00:00

abstract：:In this paper, we evaluated the power of microbiome measures taken at three time points over the growth test period (weaning, 15 and 22 weeks) to foretell growth and carcass traits in 1039 individuals of a line of crossbred pigs. We measured prediction accuracy as the correlation between actual and predicted phenotype...

journal_title：Scientific reports

authors： Maltecca C,Lu D,Schillebeeckx C,McNulty NP,Schwab C,Shull C,Tiezzi F

更新日期：2019-04-25 00:00:00

abstract：:Pterostilbene (PT), the natural dimethylated analog of resveratrol (RSV), is a potent anticarcinogen for non-small-cell lung cancer (NSCLC), but its anti-NSCLC mechanisms remain unclear. In this study, we show that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling (i.e.,...

journal_title：Scientific reports

authors： Ma Z,Yang Y,Di S,Feng X,Liu D,Jiang S,Hu W,Qin Z,Li Y,Lv J,Fan C,Yan X,Li X

更新日期：2017-08-14 00:00:00

abstract：:Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and...

journal_title：Scientific reports

authors： Khaydukov EV,Mironova KE,Semchishen VA,Generalova AN,Nechaev AV,Khochenkov DA,Stepanova EV,Lebedev OI,Zvyagin AV,Deyev SM,Panchenko VY

更新日期：2016-10-12 00:00:00

abstract：:A biochemical reaction model clarifies for the first time how cold atmospheric plasmas (CAPs) affect mitochondrial redox homeostasis and energy metabolism. Fundamental mitochondrial functions in pyruvic acid oxidation, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation involving the respiratory chain (RC...

journal_title：Scientific reports

authors： Murakami T

更新日期：2019-11-20 00:00:00

abstract：:Coccolithophores are single-celled photosynthesizing marine algae, responsible for half of the calcification in the surface ocean, and exert a strong influence on the distribution of carbon among global reservoirs, and thus Earth's climate. Calcification in the surface ocean decreases the buffering capacity of seawate...

journal_title：Scientific reports

authors： McClelland HL,Barbarin N,Beaufort L,Hermoso M,Ferretti P,Greaves M,Rickaby RE

更新日期：2016-09-28 00:00:00

abstract：:The identification of the most influential individuals in structured populations is an important research question, with many applications across the social and natural sciences. Here, we study this problem in evolutionary populations on static networks, where invading cheaters can lead to the collapse of cooperation....

journal_title：Scientific reports

authors： Yang G,Cavaliere M,Zhu C,Perc M

更新日期：2020-02-10 00:00:00

abstract：:Elucidating arbuscular mycorrhizal (AM) fungal responses to elevation changes is critical to improve understanding of microbial function in ecosystems under global asymmetrical climate change scenarios. Here we examined AM fungal community in a two-year reciprocal translocation of vegetation-intact soil blocks along a...

journal_title：Scientific reports

authors： Yang W,Zheng Y,Gao C,Duan JC,Wang SP,Guo LD

更新日期：2016-11-09 00:00:00

abstract：:We theoretically investigate the mechanism of ferroelectric switching via interlayer shear in 3R MoS2 using first principles and lattice dynamics calculations. First principle calculations show the prominent anharmonic coupling of the infrared inactive interlayer shear and the infrared active phonons. The nonlinear co...

journal_title：Scientific reports

authors： Park J,Yeu IW,Han G,Hwang CS,Choi JH

更新日期：2019-10-17 00:00:00

abstract：:Genome engineering is a rapidly evolving field that benefits from the availability of different tools that can be used to perform genome manipulation tasks. We describe here the development of the Flp-TAL recombinases that can target genomic FRT-like sequences in their native chromosomal locations. Flp-TAL recombinase...

journal_title：Scientific reports

authors： Voziyanova E,Li F,Shah R,Voziyanov Y

更新日期：2020-10-15 00:00:00

abstract：:To investigate whether mitochondrial DNA haplogroups M or N are related to occurrence or manifestations of systemic lupus erythematosus (SLE), we collected M/N haplogrouping and clinical characteristics from 868 Han Chinese women with SLE, as well as for 870 age-matched healthy Han Chinese control women. M/N haplogrou...

journal_title：Scientific reports

authors： Tang Y,Wang L,Zhu M,Yang M,Zhong K,Du Q,Zhang H,Gui M

更新日期：2015-06-03 00:00:00

abstract：:In this work, we report lateral heterojunction formation in as-exfoliated MoS2 flakes by thickness modulation. Kelvin probe force microscopy is used to map the surface potential at the monolayer-multilayer heterojunction, and consequently the conduction band offset is extracted. Scanning photocurrent microscopy is per...

journal_title：Scientific reports

authors： Tosun M,Fu D,Desai SB,Ko C,Kang JS,Lien DH,Najmzadeh M,Tongay S,Wu J,Javey A

更新日期：2015-06-30 00:00:00

abstract：:Recently, some very tight constraints of annihilating dark matter have been obtained from gamma-ray data of the Milky Way and Milky Way dwarf spheroidal satellite galaxies. In this article, we report that there are two excellent galaxy clusters (A2877 and Fornax) which can provide interesting constraints for annihilat...

journal_title：Scientific reports

authors： Chan MH,Leung CH

更新日期：2017-11-02 00:00:00

abstract：:Light beams with extraordinary spatial structures, such as the Airy beam (AB), the Bessel-Gaussian beam (BGB) and the Laguerre-Gaussian beam (LGB), are widely studied and applied in many optical scenarios. We report on preparation of light beams with controllable spatial structures through sum frequency generation (SF...

journal_title：Scientific reports

authors： Zhou ZY,Li Y,Ding DS,Jiang YK,Zhang W,Shi S,Shi BS,Guo GC

更新日期：2014-07-10 00:00:00

abstract：:The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method an...

journal_title：Scientific reports

authors： Sharifi M,Hasan A,Nanakali NMQ,Salihi A,Qadir FA,Muhammad HA,Shekha MS,Aziz FM,Amen KM,Najafi F,Yousefi-Manesh H,Falahati M

更新日期：2020-04-03 00:00:00

abstract：:Magnetron sputtering techniques were used to prepare molecularly smooth titanium thin films possessing an average roughness between 0.18 nm and 0.52 nm over 5 μm × 5 μm AFM scanning areas. Films with an average roughness of 0.52 nm or lower were found to restrict the extent of P. aeruginosa cell attachment, with less ...

journal_title：Scientific reports

authors： Ivanova EP,Truong VK,Webb HK,Baulin VA,Wang JY,Mohammodi N,Wang F,Fluke C,Crawford RJ

更新日期：2011-01-01 00:00:00

abstract：:Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. H...

journal_title：Scientific reports

authors： Fala AM,Oliveira JF,Adamoski D,Aricetti JA,Dias MM,Dias MVB,Sforça ML,Lopes-de-Oliveira PS,Rocco SA,Caldana C,Dias SMG,Ambrosio ALB

更新日期：2015-08-03 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play diverse roles in biological processes. Aedes aegypti (Ae. aegypti), a blood-sucking mosquito, is the principal vector responsible for replication and transmission of arboviruses including dengue, Zika, and Chikungunya virus. Systematic identification and developmental characterisatio...

journal_title：Scientific reports

authors： Azlan A,Obeidat SM,Yunus MA,Azzam G

更新日期：2019-08-21 00:00:00

abstract：:In humans, oxytocin (OT) enhances prosocial behaviour. However, it is still unclear how the prosocial effects of OT are modulated by emotional features and/or individuals' characteristics. In a placebo-controlled design, we tested 20 healthy male volunteers to investigate these behavioural and neurophysiological modul...

journal_title：Scientific reports

authors： Hirosawa T,Kikuchi M,Higashida H,Okumura E,Ueno S,Shitamichi K,Yoshimura Y,Munesue T,Tsubokawa T,Haruta Y,Nakatani H,Hashimoto T,Minabe Y

更新日期：2012-01-01 00:00:00

abstract：:In this report, we propose and demonstrate an air-mode photonic crystal ring resonator (PhCRR) on silicon-on-insulator platform. Air mode is utilized to confine the optical field into photonic crystal (PhC) air holes, which is confirmed by the three-dimensional finite-difference time-domain simulation. PhCRR structure...

journal_title：Scientific reports

authors： Gao G,Zhang Y,Zhang H,Wang Y,Huang Q,Xia J

更新日期：2016-01-28 00:00:00

abstract：:Human children show unique cognitive skills for dealing with the social world but their cognitive performance is paralleled by great apes in many tasks dealing with the physical world. Recent studies suggested that members of a songbird family-corvids-also evolved complex cognitive skills but a detailed understanding ...

journal_title：Scientific reports

authors： Pika S,Sima MJ,Blum CR,Herrmann E,Mundry R

更新日期：2020-12-10 00:00:00