Riboflavin photoactivation by upconversion nanoparticles for cancer treatment.

abstract：:The transcription apparatus (TA) is a huge molecular machine. It detects the time-varying concentrations of transcriptional activators and initiates mRNA transcripts at appropriate rates. Based on the general structural organizations of the TA, we propose how the TA dynamically orchestrates transcriptional responses. ...

journal_title：Scientific reports

authors： Wang Y,Liu F,Wang W

更新日期：2012-01-01 00:00:00

abstract：:Despite phages' ubiquitous presence and great importance in shaping microbial communities, little is known about the diversity of specific phages in different ecological niches. Here, we isolated, sequenced, and characterized 38 Escherichia coli-infecting phages (coliphages) from poultry faeces to gain a better unders...

journal_title：Scientific reports

authors： Sørensen PE,Van Den Broeck W,Kiil K,Jasinskyte D,Moodley A,Garmyn A,Ingmer H,Butaye P

更新日期：2020-09-16 00:00:00

abstract：:To evaluate the corneal spherical aberrations in cataract patients with and without high myopia, we conducted a retrospective case series of 502 cataract eyes with high myopia and 1500 age-related cataract eyes and measure their corneal biometric data and axial length using Pentacam and IOLMaster. Both the anterior an...

journal_title：Scientific reports

authors： Zhang M,Qian D,Jing Q,Chen J,Jiang Y

更新日期：2019-02-05 00:00:00

abstract：:Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determi...

journal_title：Scientific reports

authors： Dang L,Teng M,Li HW,Li HZ,Ma SM,Zhao P,Li XJ,Deng RG,Zhang GP,Luo J

更新日期：2017-09-14 00:00:00

abstract：:IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates. Forty-three isolates were observed to carry IncX4 type plasmid, among which 13 were identified to carry mcr-1 ...

journal_title：Scientific reports

authors： Sun J,Fang LX,Wu Z,Deng H,Yang RS,Li XP,Li SM,Liao XP,Feng Y,Liu YH

更新日期：2017-03-24 00:00:00

abstract：:Insertion sequences (ISs) are ubiquitous and abundant mobile genetic elements in prokaryotic genomes. ISs often encode only one protein, the transposase, which catalyzes their transposition. Recent studies have shown that transposases of many different IS families interact with the β sliding clamp, a DNA replication f...

journal_title：Scientific reports

authors： Díaz-Maldonado H,Gómez MJ,Moreno-Paz M,San Martín-Úriz P,Amils R,Parro V,López de Saro FJ

更新日期：2015-08-26 00:00:00

abstract：:During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to vasa vasorum, also the adventitial lymphatic capillary bed is expanding during plaque development in humans and mouse models of atherosclerosis....

journal_title：Scientific reports

authors： Rademakers T,van der Vorst EP,Daissormont IT,Otten JJ,Theodorou K,Theelen TL,Gijbels M,Anisimov A,Nurmi H,Lindeman JH,Schober A,Heeneman S,Alitalo K,Biessen EA

更新日期：2017-03-28 00:00:00

abstract：:Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit cards and computer hard drives. Here we experimentally show that a similar principle can be applied for imprinting th...

journal_title：Scientific reports

authors： Brisbois J,Motta M,Avila JI,Shaw G,Devillers T,Dempsey NM,Veerapandian SK,Colson P,Vanderheyden B,Vanderbemden P,Ortiz WA,Nguyen ND,Kramer RB,Silhanek AV

更新日期：2016-06-06 00:00:00

abstract：:Gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) is an activatable fluorescent probe that can be activated by γ-glutamyltranspeptidase (GGT). The expression of GGT in the kidney, which is one of the major organs exhibiting enhanced GGT expression, is exclusively localised to the cortex. Here, we aimed to inves...

journal_title：Scientific reports

authors： Iyama T,Takata T,Yamada K,Mae Y,Taniguchi S,Ida A,Ogawa M,Yamamoto M,Hamada S,Fukuda S,Kanda T,Sugihara T,Isomoto H,Urano Y

更新日期：2020-07-21 00:00:00

abstract：:Natal habitat preference induction (NHPI) occurs when characteristics of the natal habitat influence the future habitat selection of an animal. However, the influence of NHPI after the dispersal phase has received remarkably little attention. We tested whether exposure to humans in the natal habitat helps understand w...

journal_title：Scientific reports

authors： Milleret C,Ordiz A,Sanz-Pérez A,Uzal A,Carricondo-Sanchez D,Eriksen A,Sand H,Wabakken P,Wikenros C,Åkesson M,Zimmermann B

更新日期：2019-04-25 00:00:00

abstract：:A Quality Improvement bundle was implemented with the goal of standardizing the multidisciplinary approach to delivery room management. We used a Pre-Post Quality Improvement initiative with the following aims: (1) Placement of a functioning pulse oximeter by two minutes after birth, (2) Delayed intubation, (3) Normot...

journal_title：Scientific reports

authors： Sauer CW,Boutin MA,Fatayerji AN,Proudfoot JA,Fatayerji NI,Golembeski DJ

更新日期：2016-11-21 00:00:00

abstract：:Metallic glasses are disordered materials that offer the unique ability to perform thermoplastic forming operations at low thermal budget while preserving excellent mechanical properties such as high strength, large elastic strain limits, and wear resistance owing to the metallic nature of bonding and lack of internal...

journal_title：Scientific reports

authors： Magagnosc DJ,Chen W,Kumar G,Schroers J,Gianola DS

更新日期：2016-01-20 00:00:00

abstract：:Recently, a genome-wide analysis identified DNA methylation of the HIF3A (hypoxia-inducible factor 3A) as strongest correlate of BMI. Here we tested the hypothesis that HIF3A mRNA expression and CpG-sites methylation in adipose tissue (AT) and genetic variants in HIF3A are related to parameters of AT distribution and ...

journal_title：Scientific reports

authors： Pfeiffer S,Krüger J,Maierhofer A,Böttcher Y,Klöting N,El Hajj N,Schleinitz D,Schön MR,Dietrich A,Fasshauer M,Lohmann T,Dreßler M,Stumvoll M,Haaf T,Blüher M,Kovacs P

更新日期：2016-06-27 00:00:00

abstract：:The intrauterine environment is particularly vulnerable to environmental exposures. We previously established a mouse model that provided evidence for pregnancy complications and placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biphenyls (PCBs). Importantly, these effects ...

journal_title：Scientific reports

authors： Kalkunte S,Huang Z,Lippe E,Kumar S,Robertson LW,Sharma S

更新日期：2017-01-10 00:00:00

abstract：:Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to searc...

journal_title：Scientific reports

authors： Nowak JK,Grzybowska-Chlebowczyk U,Landowski P,Szaflarska-Poplawska A,Klincewicz B,Adamczak D,Banasiewicz T,Plawski A,Walkowiak J

更新日期：2014-04-24 00:00:00

abstract：:The magnetization process is a very important probe to study magnetic materials, particularly in search of spin-liquid states in quantum spin systems. Regrettably, however, progress of the theoretical analysis has been unsatisfactory, mostly because it is hard to obtain sufficient numerical data to support the theory....

journal_title：Scientific reports

authors： Nakamura T

更新日期：2020-08-26 00:00:00

abstract：:Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually requires prompt surgery to prevent further detachment and restore sensory function. Although several individual factors have been suggested, a systems level understanding of molecular pathomechanisms underlying this severe eye disorder i...

journal_title：Scientific reports

authors： Öhman T,Gawriyski L,Miettinen S,Varjosalo M,Loukovaara S

更新日期：2021-01-13 00:00:00

abstract：:The Gram-negative bacterium B. pertussis is the causative agent of whooping cough. This infection is re-emerging and new features related to Bordetella pathogenesis and microbiology could be relevant to defeat it. Therefore, we focused our attention on BP1253, a predicted exported protein from B. pertussis erroneously...

journal_title：Scientific reports

authors： Moramarco F,Pezzicoli A,Salvini L,Leuzzi R,Pansegrau W,Balducci E

更新日期：2019-11-19 00:00:00

abstract：:The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the association between MCV and death attributable to cerebrovascular disease (CVD) and cardiovascular disease (CAD) in...

journal_title：Scientific reports

authors： Wu TH,Fann JC,Chen SL,Yen AM,Wen CJ,Lu YR,Chen HH,Chiu SY,Liou HH

更新日期：2018-11-08 00:00:00

abstract：:There a few reports of rhodamine-based fluorescent sensors for selective detection of only Al3+, due to the challenge of identifying a suitable ligand for binding Al3+ ion. The use of fluorophore moieties appended to a polymer backbone for sensing applications is far from mature. Here, we report a new fluorescent prob...

journal_title：Scientific reports

authors： Gandra UR,Courjaret R,Machaca K,Al-Hashimi M,Bazzi HS

更新日期：2020-11-11 00:00:00

abstract：:Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance...

journal_title：Scientific reports

authors： Porter HF,O'Reilly PF

更新日期：2017-03-13 00:00:00

abstract：:Hereditary tyrosinemia type 1 (HT1) is a severe inborn error of metabolism, impacting the tyrosine catabolic pathway with a high incidence of hepatocellular carcinoma (HCC). Using a HT1 murine model, we investigated the changes in profiles of circulating and hepatic miRNAs. The aim was to determine if plasma miRNAs co...

journal_title：Scientific reports

authors： Angileri F,Morrow G,Scoazec JY,Gadot N,Roy V,Huang S,Wu T,Tanguay RM

更新日期：2016-06-10 00:00:00

abstract：:Nanoparticles are widely used in commodities, and pregnant women are inevitably exposed to these particles. The placenta protects the growing fetus from foreign or toxic materials, and provides energy and oxygen. Here we report that autophagy, a cellular mechanism to maintain homeostasis, engulfs platinum nanoparticle...

journal_title：Scientific reports

authors： Nakashima A,Higashisaka K,Kusabiraki T,Aoki A,Ushijima A,Ono Y,Tsuda S,Shima T,Yoshino O,Nagano K,Yoshioka Y,Tsutsumi Y,Saito S

更新日期：2019-04-02 00:00:00

abstract：:Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas data on brain-dead donors (DBD) are scarce. To assess the impact of end-ischemic HOPE i...

journal_title：Scientific reports

authors： Patrono D,Surra A,Catalano G,Rizza G,Berchialla P,Martini S,Tandoi F,Lupo F,Mirabella S,Stratta C,Salizzoni M,Romagnoli R

更新日期：2019-06-27 00:00:00

abstract：:Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then anal...

journal_title：Scientific reports

authors： Guo R,Wan Y,Xu D,Cui L,Deng M,Zhang G,Jia R,Zhou W,Wang Z,Deng K,Huang M,Wang F,Zhang Y

更新日期：2016-07-15 00:00:00

abstract：:The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore has therapeutic po...

journal_title：Scientific reports

authors： Bijsmans IT,Guercini C,Ramos Pittol JM,Omta W,Milona A,Lelieveld D,Egan DA,Pellicciari R,Gioiello A,van Mil SW

更新日期：2015-09-15 00:00:00

abstract：:Infection diagnosis and antibiotic susceptibility testing (AST) are time-consuming and often laborious clinical practices. This paper presents a microwave-microfluidic biosensor for rapid, contactless and non-invasive device for testing the concentration and growth of Escherichia Coli (E. Coli) in medium solutions of ...

journal_title：Scientific reports

authors： Narang R,Mohammadi S,Ashani MM,Sadabadi H,Hejazi H,Zarifi MH,Sanati-Nezhad A

更新日期：2018-10-25 00:00:00

abstract：:On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feed...

journal_title：Scientific reports

authors： Kanuri BN,Kanshana JS,Rebello SC,Pathak P,Gupta AP,Gayen JR,Jagavelu K,Dikshit M

更新日期：2017-01-20 00:00:00

abstract：:The physiological importance of CD151 tetraspanin is known from somatic cells and its outside-in signalling through integrins was described. In male germ cells, two tetraspanins, CD9 and CD81, are involved in sperm-egg membrane fusion, and similarly to integrins, they occupy characteristic regions. We report here on a...

journal_title：Scientific reports

authors： Jankovicova J,Frolikova M,Palenikova V,Valaskova E,Cerny J,Secova P,Bartokova M,Horovska L,Manaskova-Postlerova P,Antalikova J,Komrskova K

更新日期：2020-03-09 00:00:00

abstract：:New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to...

journal_title：Scientific reports

authors： Gonzalez R,Garitaonandia I,Abramihina T,Wambua GK,Ostrowska A,Brock M,Noskov A,Boscolo FS,Craw JS,Laurent LC,Snyder EY,Semechkin RA

更新日期：2013-01-01 00:00:00