Abstract:
:Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually requires prompt surgery to prevent further detachment and restore sensory function. Although several individual factors have been suggested, a systems level understanding of molecular pathomechanisms underlying this severe eye disorder is lacking. To address this gap in knowledge we performed the molecular level systems pathology analysis of the vitreous from 127 patients with RRD using state-of-the art quantitative mass spectrometry to identify the individual key proteins, as well as the biochemical pathways contributing to the development of the disease. RRD patients have specific vitreous proteome profiles compared to other diseases such as macular hole, pucker, or proliferative diabetic retinopathy eyes. Our data indicate that various mechanisms, including glycolysis, photoreceptor death, and Wnt and MAPK signaling, are activated during or after the RRD to promote retinal cell survival. In addition, platelet-mediated wound healing processes, cell adhesion molecules reorganization and apoptotic processes were detected during RRD progression or proliferative vitreoretinopathy formation. These findings improve the understanding of RRD pathogenesis, identify novel targets for treatment of this ophthalmic disease, and possibly affect the prognosis of eyes treated or operated upon due to RRD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Öhman T,Gawriyski L,Miettinen S,Varjosalo M,Loukovaara Sdoi
10.1038/s41598-020-80005-wsubject
Has Abstractpub_date
2021-01-13 00:00:00pages
966issue
1issn
2045-2322pii
10.1038/s41598-020-80005-wjournal_volume
11pub_type
杂志文章abstract::Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-typ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61882-7
更新日期:2020-03-31 00:00:00
abstract::Bioerosion is a process with a high socio-economic impact that contributes to coastal retreat, and likely to increase with climate change. Whereas limestone bioerosion is well explained by a combination of mechanical and chemical pathways, the bioerosion mechanisms of silicates, which are harder and chemically more re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70265-x
更新日期:2020-08-07 00:00:00
abstract::Src kinase is known to regulate fibroblast migration. However, the contribution of integrin and Src kinase interaction to lung fibrosis has not been mechanistically investigated. Our data demonstrate that integrin alpha v (αV) recruited Src kinase and that leads to subsequent Src activation in fibroblasts plated on fi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46357
更新日期:2017-04-11 00:00:00
abstract::A new family of 99mTc(I)- tricarbonyl complexes and 125I-heteroaromatic compounds bearing an acridine orange (AO) DNA targeting unit was evaluated for Auger therapy. Characterization of the DNA interaction, performed with the non-radioactive Re and 127I congeners, confirmed that all compounds act as DNA intercalators....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42544
更新日期:2017-02-13 00:00:00
abstract::It is urgent to find an optimised therapy regimen for the control of MDR-TB globally. This study aimed to evaluate the efficiacy and safety of a combined regimen of rhIL-2 injection and standard chemotherapy within 18-month duration in a randomized controlled trial conducted in 14 centres in eastern China. From Jan. 2...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-017-18200-5
更新日期:2017-12-19 00:00:00
abstract::Marek's disease virus (MDV) is a preferred vector in the construction of recombinant vaccines. However, bivalent vaccine based on MDV that confers full protection against both very virulent Marek's and infectious bursal disease virus (IBDV) infections in chickens has not been produced. Here we developed a system utili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39263
更新日期:2016-12-16 00:00:00
abstract::Kabuki Syndrome (KS) is a rare disorder characterized by distinctive facial features, short stature, skeletal abnormalities, and neurodevelopmental deficits. Previously, we showed that loss of function of RAP1A, a RAF1 regulator, can activate the RAS/MAPK pathway and cause KS, an observation recapitulated in other gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28709-y
更新日期:2018-07-17 00:00:00
abstract::The p38 MAPKs play important roles in the regulation of balance between cell survival and cell death on the development of various cancers. However, the roles of p38 MAPKs regulating apoptotic effects on Leydig tumor cells remain unclear. In the present study, we showed that cordycepin (3'-deoxyadenosine) selectively ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13372
更新日期:2015-08-25 00:00:00
abstract::Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However, these therapies do not experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause problemat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13803-4
更新日期:2017-10-17 00:00:00
abstract::Much of atmospheric water originates from transpiration, the process by which plants release H2O from pores, known as stomata, that simultaneously intake CO2 for photosynthesis. Controlling stomatal aperture can regulate the extent of water transport in response to dynamic environmental factors including osmotic stres...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32394
更新日期:2016-08-31 00:00:00
abstract::This corrects the article DOI: 10.1038/srep20067. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46387
更新日期:2017-06-30 00:00:00
abstract::A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05513
更新日期:2014-07-01 00:00:00
abstract::Hypoxia-inducible factor (HIF)-1α and HIF-2α play an important role in liver fibrosis. von Hippel-Lindau protein (VHL), a key mediator of HIF-α, regulates fibrosis in an organ- and cell-specific way. In this study, human liver samples were collected from hepatitis C-, alcoholic-, and cholestatic-associated fibrotic an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41038
更新日期:2017-01-23 00:00:00
abstract::Wet-chemistry methods have crucial advantages for the synthesis of nanostructures, including simple, low-cost, large-area, and low-temperature deposition on almost arbitrary substrates. Nevertheless, the rational design of improved wet-chemistry procedures is extremely difficult because, in practice, only post-synthes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06285
更新日期:2014-09-05 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-30923-7
更新日期:2018-09-07 00:00:00
abstract::Magnetic skyrmions are promising candidates for the next generation of spintronic devices due to their small size and topologically protected structure. One challenge for using these magnetic states in applications lies on controlling the nucleation process and stabilization that usually requires an external force. He...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40705-4
更新日期:2019-03-11 00:00:00
abstract::Fluid strategy is the key to the successful management of patients with sepsis. However, previous studies failed to consider individualized treatment strategy, and clinical trials typically included patients with sepsis as a homogeneous study population. We aimed to develop sequential decision rules for managing fluid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74906-z
更新日期:2020-10-21 00:00:00
abstract::Malachite green is a common environmental pollutant that poses a great threat to non-target organisms, including humans. This study reports the characterization of a bacterial strain, Pseudomonas veronii JW3-6, which was isolated from a malachite green enrichment culture. This strain degraded malachite green efficient...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61442-z
更新日期:2020-03-11 00:00:00
abstract::Streptococcus anginosus is increasingly recognized as an opportunistic pathogen. However, our knowledge about virulence determinants in this species is scarce. One exception is the streptolysin-S (SLS) homologue responsible for the β-hemolytic phenotype of the S. anginosus type strain. In S. anginosus the expression o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27334-z
更新日期:2018-06-13 00:00:00
abstract::Weight regain is one of the most common problems in the long-term after bariatric surgery. It is unknown if high-intensity exercise programs applied in late phases of post-surgical follow-up could counteract this trend. After a 3-year follow-up, 21 patients underwent sleeve gastrectomy were randomized into an exercise...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-60044-z
更新日期:2020-02-20 00:00:00
abstract::Nanoliposomal formulation of C6-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute treatment (30 min) of melanoma and breast cancer cells with nanoliposomal C6-ceramide (NaL-C6) may suppress cell migration without inducing cell dea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09275
更新日期:2015-03-20 00:00:00
abstract::Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31450
更新日期:2016-08-12 00:00:00
abstract::The spirochete Leptospira spp. can move in liquid and on a solid surface using two periplasmic flagella (PFs), and its motility is an essential virulence factor for the pathogenic species. Mammals are infected with the spirochete through the wounded dermis, which implies the importance of behaviors on the boundary wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70897-z
更新日期:2020-08-18 00:00:00
abstract::Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensors for efficient and continuous monitoring of analytes in patients. The main objective of this research is to d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41326-7
更新日期:2019-03-22 00:00:00
abstract::Integrins are α/β heterodimeric transmembrane adhesion receptors. Evidence exists that their transmembrane domain (TMD) separates upon activation. Subunit-specific differences in activation sensitivity of integrins were reported. However, whether sequence variations in the TMD lead to differential TMD association has ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23778-5
更新日期:2018-04-10 00:00:00
abstract::Transient gene expression approaches are valuable tools for rapid introduction of genes of interest and characterization of their functions in plants. Although agroinfiltration is the most effectively and routinely used method for transient expression of multiple genes in various plant species, this approach has been ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22436
更新日期:2016-02-29 00:00:00
abstract::Recent studies demonstrated that sinogram affirmed iterative reconstructions (SAFIRE) can produce higher-resolution images with greater robustness for the reduction of various imaging artefacts. Eighty-five patients were prospectively evaluated and underwent a high-pitch spiral acquisition CT scan. In-stent noise, sig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07499-9
更新日期:2017-07-31 00:00:00
abstract::High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However, cross-investigations between several h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36076
更新日期:2016-10-26 00:00:00
abstract::The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand the function of Cdh2 in mEpiSCs, we compared the expression of plurip...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14722
更新日期:2015-09-30 00:00:00
abstract::The pectin methylesterase action is usually studied in a homogeneous aqueous medium in the presence of a large excess of soluble substrate and water. However in the cell wall, the water content is much lower, the substrate is cross-linked with itself or with other polymers, and the enzyme has to diffuse through the so...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49108-x
更新日期:2019-08-29 00:00:00