Multivariate simulation framework reveals performance of multi-trait GWAS methods.

abstract：:The p38 MAPKs play important roles in the regulation of balance between cell survival and cell death on the development of various cancers. However, the roles of p38 MAPKs regulating apoptotic effects on Leydig tumor cells remain unclear. In the present study, we showed that cordycepin (3'-deoxyadenosine) selectively ...

journal_title：Scientific reports

authors： Pan BS,Wang YK,Lai MS,Mu YF,Huang BM

更新日期：2015-08-25 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep42627. ...

journal_title：Scientific reports

authors： Li Z,Lan X,Han R,Wang J,Huang Y,Sun J,Guo W,Chen H

更新日期：2018-04-06 00:00:00

abstract：:Amplification of liver injury is mediated by macrophages but the signaling by which the macrophage inflammasome enhances liver injury is not completely understood. The CCAAT/Enhancer Binding Protein-β (C/EBPβ) is a critical signaling molecule for macrophages because expression of a dominant inhibitor of C/EBPβ DNA-bin...

journal_title：Scientific reports

authors： Buck M,Solis-Herruzo J,Chojkier M

更新日期：2016-04-12 00:00:00

abstract：:The present work demonstrates the synthesis, characterization and biological activities of different concentrations of tin doped indium oxide nanoparticles (Sn doped In2O3 NPs), i.e., (Sn/In = 5%, 10% and 15%). We have synthesized different size (38.11 nm, 18.46 nm and 10.21 nm) of Sn doped In2O3 NPs. by using an ultr...

journal_title：Scientific reports

authors： Rehman S,Asiri SM,Khan FA,Jermy BR,Ravinayagam V,Alsalem Z,Jindan RA,Qurashi A

更新日期：2020-02-24 00:00:00

abstract：:Nine new bicyclic cembranoids, sarcophytrols M-U(1-9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of t...

journal_title：Scientific reports

authors： Liang LF,Chen WT,Li XW,Wang HY,Guo YW

更新日期：2017-04-21 00:00:00

abstract：:It is possible to accurately and economically predict change in protein-protein interaction energy upon mutation (ΔΔG), when a high-resolution structure of the complex is available. This is of growing usefulness for design of high-affinity or otherwise modified binding proteins for therapeutic, diagnostic, industrial,...

journal_title：Scientific reports

authors： Dourado DF,Flores SC

更新日期：2016-05-13 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In...

journal_title：Scientific reports

authors： Park HW,Park CG,Park M,Lee SH,Park HR,Lim J,Paek SH,Choy YB

更新日期：2020-06-12 00:00:00

abstract：:Meckel syndrome (MKS) is an inherited autosomal recessive hepatorenal fibrocystic syndrome, caused by mutations in TMEM67, characterized by occipital encephalocoele, renal cysts, hepatic fibrosis, and polydactyly. Here we describe an ovine model of MKS, with kidney and liver abnormalities, without polydactyly or occip...

journal_title：Scientific reports

authors： Stayner C,Poole CA,McGlashan SR,Pilanthananond M,Brauning R,Markie D,Lett B,Slobbe L,Chae A,Johnstone AC,Jensen CG,McEwan JC,Dittmer K,Parker K,Wiles A,Blackburne W,Leichter A,Leask M,Pinnapureddy A,Jennings M,Hor

更新日期：2017-05-09 00:00:00

abstract：:Survival of many species, from insects and birds to human and non-human mammals, requires synchronized activity. Among humans, synchrony occurs even at the level of autonomic functioning; people interacting often show mutual, simultaneous changes in activity of the sympathetic or parasympathetic branches of the autono...

journal_title：Scientific reports

authors： Danyluck C,Page-Gould E

更新日期：2019-06-03 00:00:00

abstract：:Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly i...

journal_title：Scientific reports

authors： Marko IP,Broderick CA,Jin S,Ludewig P,Stolz W,Volz K,Rorison JM,O'Reilly EP,Sweeney SJ

更新日期：2016-07-01 00:00:00

abstract：:Anserine/carnosine supplementation improves cerebral blood flow and verbal episodic memory in elderly people, as we previously reported. Anserine's buffering activity is superior to that of carnosine at neutral pH. In human sera, carnosine but not anserine is rapidly cleaved by carnosinase, limiting its effectiveness....

journal_title：Scientific reports

authors： Kaneko J,Enya A,Enomoto K,Ding Q,Hisatsune T

更新日期：2017-10-03 00:00:00

abstract：:Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucid...

journal_title：Scientific reports

authors： Mizuno Y,Shimada S,Akiyama Y,Watanabe S,Aida T,Ogawa K,Ono H,Mitsunori Y,Ban D,Kudo A,Arii S,Yamaoka S,Tanabe M,Tanaka S

更新日期：2018-01-08 00:00:00

abstract：:The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion is mediated by either Gq/11 proteins or βarrestin1 (βarr1), both of which can couple to its type 1 receptors (AT₁Rs), present in adrenocortical zona glomerulosa (AZG) cell membranes. In the present study, we examined the relat...

journal_title：Scientific reports

authors： Dabul S,Bathgate-Siryk A,Valero TR,Jafferjee M,Sturchler E,McDonald P,Koch WJ,Lymperopoulos A

更新日期：2015-01-29 00:00:00

abstract：:Translesion synthesis (TLS) is the mechanism by which DNA polymerases replicate through unrepaired DNA lesions. TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites. Pol...

journal_title：Scientific reports

authors： Lau WC,Li Y,Zhang Q,Huen MS

更新日期：2015-10-27 00:00:00

abstract：:Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies on using light patterns featuring substantial arrays of intensity minima for d...

journal_title：Scientific reports

authors： Chmyrov A,Leutenegger M,Grotjohann T,Schönle A,Keller-Findeisen J,Kastrup L,Jakobs S,Donnert G,Sahl SJ,Hell SW

更新日期：2017-03-20 00:00:00

abstract：:The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...

journal_title：Scientific reports

authors： Nair NU,Das A,Rogkoti VM,Fokkelman M,Marcotte R,de Jong CG,Koedoot E,Lee JS,Meilijson I,Hannenhalli S,Neel BG,de Water BV,Le Dévédec SE,Ruppin E

更新日期：2019-07-29 00:00:00

abstract：:Autotaxin (ATX) is a secreted enzyme metabolized by liver sinusoidal endothelial cells that has been associated with liver fibrosis. We evaluated serum ATX values in 128 treatment-naïve, histologically assessed primary biliary cholangitis (PBC) patients and 80 healthy controls for comparisons of clinical parameters in...

journal_title：Scientific reports

authors： Joshita S,Umemura T,Usami Y,Yamashita Y,Norman GL,Sugiura A,Yamazaki T,Fujimori N,Kimura T,Matsumoto A,Igarashi K,Yoshizawa K,Ota M,Tanaka E

更新日期：2018-05-25 00:00:00

abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...

journal_title：Scientific reports

authors： Mangayil R,Karp M,Lamminmäki U,Santala V

更新日期：2016-10-27 00:00:00

abstract：:The mosquito, Aedes baisasi, which inhabits brackish mangrove swamps, is known to feed on fish. However, its host assemblage has not been investigated at the species level. We amplified and sequenced the cytochrome oxidase subunit I barcoding regions as well as some other regions from blood-fed females to identify hos...

journal_title：Scientific reports

authors： Miyake T,Aihara N,Maeda K,Shinzato C,Koyanagi R,Kobayashi H,Yamahira K

更新日期：2019-03-08 00:00:00

abstract：:At the regional scale, although environmental factors are known to shape the distributions of belowground communities in terrestrial ecosystems, these environmental factors account for relatively low percentages of the variation in belowground communities. More of this variation might be explained by considering ecosy...

journal_title：Scientific reports

authors： Wang B,Wu Y,Chen D

更新日期：2017-08-04 00:00:00

abstract：:Radiation weighting factor wR for photons and electrons has been defined as unity independently of the energy of the particles. However, the biological effects depend on the incident energies according to in vitro experimental data. In this study, we have quantified the energy concentration along electron tracks in te...

journal_title：Scientific reports

authors： Yachi Y,Yoshii Y,Matsuya Y,Mori R,Oikawa J,Date H

更新日期：2019-11-27 00:00:00

abstract：:Two-dimensional (2D) transition metal dichalcogenides MX2 (M = Mo, W, X = S, Se, Te) attracts enormous research interests in recent years. Its 2H phase possesses an indirect to direct bandgap transition in 2D limit, and thus shows great application potentials in optoelectronic devices. The 1T' crystalline phase transi...

journal_title：Scientific reports

authors： Chen W,Xie X,Zong J,Chen T,Lin D,Yu F,Jin S,Zhou L,Zou J,Sun J,Xi X,Zhang Y

更新日期：2019-02-25 00:00:00

abstract：:We perform this meta-analysis to compare the efficacy and safety of cryoablation versus radiofrequency ablation for patients with cavotricuspid valve isthmus dependent atrial flutter. By searching EMBASE, MEDLINE, PubMed and Cochrane electronic databases from March 1986 to September 2014, 7 randomized clinical trials ...

journal_title：Scientific reports

authors： Chen YH,Lin H,Xie CL,Zhang XT,Li YG

更新日期：2015-06-03 00:00:00

abstract：:Malachite green is a common environmental pollutant that poses a great threat to non-target organisms, including humans. This study reports the characterization of a bacterial strain, Pseudomonas veronii JW3-6, which was isolated from a malachite green enrichment culture. This strain degraded malachite green efficient...

journal_title：Scientific reports

authors： Song J,Han G,Wang Y,Jiang X,Zhao D,Li M,Yang Z,Ma Q,Parales RE,Ruan Z,Mu Y

更新日期：2020-03-11 00:00:00

abstract：:Precision medicine is continuously demanding for novel point of care systems, potentially exploitable also for in-vivo analysis. Biosensing probes based on Lab-On-Fiber Technology have been recently developed to meet these challenges. However, devices exploiting standard label-free approaches (based on ligand/target m...

journal_title：Scientific reports

authors： Aliberti A,Ricciardi A,Giaquinto M,Micco A,Bobeico E,La Ferrara V,Ruvo M,Cutolo A,Cusano A

更新日期：2017-10-31 00:00:00

abstract：:Cell therapy using intramuscular injections of autologous bone-marrow mononuclear cells (BM-MNCs) improves clinical symptoms and can prevent limb amputation in atherosclerotic peripheral arterial disease (PAD) patients with critical limb ischemia (CLI). The purpose of this study was to evaluate the effects of the numb...

journal_title：Scientific reports

authors： Yusoff FM,Kajikawa M,Takaeko Y,Kishimoto S,Hashimoto H,Maruhashi T,Nakashima A,Wahid SFSA,Higashi Y

更新日期：2020-11-16 00:00:00

abstract：:In this work, an enzymatic biofuel cell (EBC) based on a membraneless and mediatorless glucose enzymatic fuel cell system was constructed for operation in physiological conditions (pH 7.0 and temperature 37 °C). The new platform EBC made of nanocomposite, including magnetic nanoparticles (Fe3O4 NPs) and reduced graphe...

journal_title：Scientific reports

authors： Pakapongpan S,Tuantranont A,Poo-Arporn RP

更新日期：2017-10-10 00:00:00

abstract：:Tom40 is an integral protein of the mitochondrial outer membrane, which as the central component of the Translocase of the Outer Membrane (TOM) complex forms a channel for protein import. We characterize the diffusion properties of individual Tom40 molecules fused to the photoconvertable fluorescent protein Dendra2 wi...

journal_title：Scientific reports

authors： Kuzmenko A,Tankov S,English BP,Tarassov I,Tenson T,Kamenski P,Elf J,Hauryliuk V

更新日期：2011-01-01 00:00:00

abstract：:Archeological researches have proposed arguments for human mobility and long-distance trading over the Eurasia before the Silk Roads. Here we utilize biologically available strontium isotope analysis to assess the extent of pre-Silk Road population movements and cultural communications across the Asian interior. From ...

journal_title：Scientific reports

authors： Wang X,Tang Z,Wu J,Wu X,Wu Y,Zhou X

更新日期：2016-10-20 00:00:00

abstract：:Liver regeneration is a spontaneous process that occurs after liver injury, but acute liver failure is a complex and fatal disease which is difficult to treat. Cell-based therapies are promising alternative therapeutic approach for liver failure and different cell sources have been tested in this regard. We investigat...

journal_title：Scientific reports

authors： Kumar A,Kumar V,Rattan V,Jha V,Pal A,Bhattacharyya S

更新日期：2017-11-08 00:00:00