Abstract:
:The present work demonstrates the synthesis, characterization and biological activities of different concentrations of tin doped indium oxide nanoparticles (Sn doped In2O3 NPs), i.e., (Sn/In = 5%, 10% and 15%). We have synthesized different size (38.11 nm, 18.46 nm and 10.21 nm) of Sn doped In2O3 NPs. by using an ultra-sonication process. The Sn doped In2O3 NPs were characterized by by x-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) which confirmed the successful doping of tin (Sn) with Indium oxide (In2O3). Anticandidal activity was performed by standard agar dilution method using Candida albicans for the study. The minimum inhibitory/fungicidal concentration (MIC/MFC) values recorded were, 8 & >8 mg/ml for pure In2O3 NPs, 4 & 8 mg/ml for 5%, 2 & 8 mg/ml for 10%, whereas 1 & >4 mg/ml for 15% Sn doped In2O3 NPs, respectively. The topographical alteration caused by Sn doped In2O3 NPs on Candida cells, was clearly observed by SEM examination. A significant enhancement in anticandidal activity was seen, when Candida cells were exposed to (Sn/In = 5%, 10% and 15%). Moreover, we have also evaluated the impact of Sn-In2O3 NPs on human colorectal carcinoma cells (HCT-116). The results demonstrated that Sn-In2O3 NPs (Sn/In = 5%, 10% and 15%), caused dose dependent decrease in the cancer cell viability as the low dosage (2.0 mg/mL) showed 62.11% cell viability, while 4.0, 8.0, 16.0, 32.0 mg/mL dosages showed 20.45%, 18.25%, 16.58%, and 15.58% cell viability. In addition, the treatment of Sn-In2O3 NPs also showed significant cellular and anatomical changes in cancer cells as examined by microscopes. We have also examined the impact of Sn-In2O3 NPs (5%, 10%, 15%) on normal cells (HEK-293) and the results demonstrate that Sn-In2O3 NPs did not reduce the cell viability of normal cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rehman S,Asiri SM,Khan FA,Jermy BR,Ravinayagam V,Alsalem Z,Jindan RA,Qurashi Adoi
10.1038/s41598-020-60295-wsubject
Has Abstractpub_date
2020-02-24 00:00:00pages
3228issue
1issn
2045-2322pii
10.1038/s41598-020-60295-wjournal_volume
10pub_type
杂志文章abstract::Ecological adaptations to seasonal changes are often observed in the phenotypic traits of plants and animals, and these adaptations are usually expressed through the production of different biochemical end products. In this study, ecological adaptations are observed in a biochemical pathway without alteration of the e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20234
更新日期:2016-02-01 00:00:00
abstract::The current flowing through a Mott spin junction depends on the relative spin orientation of the two ferromagnetic layers comprising the "source" and "drain" sides of the junction. The resulting current asymmetry is detected as giant or tunnelling magnetoresistance depending on whether the two ferromagnets are separat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13453-6
更新日期:2017-10-16 00:00:00
abstract::The mangrove fern genus Acrostichum grows in the extremely unstable marine intertidal zone under harsh conditions, such as high salt concentrations, tidal rhythms and long-term climate changes. To explore the phylogenetic relationships and molecular mechanisms underlying adaptations in this genus, we sequenced the tra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35634
更新日期:2016-10-26 00:00:00
abstract::Alzheimer's disease (AD) affects an estimated 5.8 million Americans, and advanced age is the greatest risk factor. AD patients have altered intestinal microbiota. Accordingly, depleting intestinal microbiota in AD animal models reduces amyloid-beta (Aβ) plaque deposition. Age-related changes in the microbiota contribu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54187-x
更新日期:2019-11-29 00:00:00
abstract::The mobilities of electrons and holes determine the applicability of any semiconductor, but their individual measurement remains a major challenge. Here, we show that time-resolved terahertz spectroscopy (TRTS) can distinguish the mobilities of minority and majority charge carriers independently of the doping-type and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32695-6
更新日期:2018-09-27 00:00:00
abstract::Mitochondria increase in number by the fission of existing mitochondria. Mitochondrial fission is needed to provide mitochondria to daughter cells during cell division. In Arabidopsis thaliana, four kinds of genes have been reported to be involved in mitochondrial fission. Two of them, DRP3 (dynamin-related protein3) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04886-0
更新日期:2017-07-04 00:00:00
abstract::Atomic force microscopy is used to conduct single-asperity friction measurements at a water-graphite interface. Local mapping of the frictional force, which is based on the degree of the cantilever twisting, shows nearly friction-free when a tip scans over a nanobubble. Surprisingly, apart from being gapless, the asso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21264-6
更新日期:2018-02-15 00:00:00
abstract::Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in human amyotrophic lateral sclerosis (ALS) transgenic mouse model expressing mutant superoxide dism...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16953
更新日期:2015-11-20 00:00:00
abstract::There are still lot of controversies whether aberrant left hepatic artery (ALHA) originating from left gastric artery should be ligated or preserved during gastric cancer (GC) surgery. We aimed to investigate this issue. We reviewed ALHA cases who had laparoscopic gastrectomy for gastric cancer at Seoul National Unive...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62587-7
更新日期:2020-04-03 00:00:00
abstract::The overall light energy to biomass conversion efficiency of plant photosynthesis is generally regarded as low. Forward genetic screens in Arabidopsis have yielded very few mutants with substantially enhanced photochemistry. Here, we report the isolation of a novel Arabidopsis mutant with a high operating efficiency o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03611-1
更新日期:2017-06-12 00:00:00
abstract::Overlapping idiopathic membranous nephropathy (IMN) and immunoglobulin A nephropathy (IgAN) is rare. This study aims to investigate the unique prognostic, clinical, and renal histopathological characteristics of IMN+IgAN. This retrospective observational study included 73 consecutive cases of IMN+IgAN and 425 cases of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11838-1
更新日期:2017-09-13 00:00:00
abstract::Solid-state spin-based qubits offer good prospects for scaling based on their long coherence times and nexus to large-scale electronic scale-up technologies. However, high-threshold quantum error correction requires a two-dimensional qubit array operating in parallel, posing significant challenges in fabrication and c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13308-0
更新日期:2017-10-17 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23237-1
更新日期:2018-04-24 00:00:00
abstract::Many animals use sounds produced by conspecifics for mate identification. Female insects and anuran amphibians, for instance, use acoustic cues to localize, orient toward and approach conspecific males prior to mating. Here we present a novel technique that utilizes multiple, distributed sound-indication devices and a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11150-y
更新日期:2017-09-05 00:00:00
abstract::The modifier protein, ubiquitin (Ub) regulates various cellular pathways by controlling the fate of substrates to which it is conjugated. Ub moieties are also conjugated to each other, forming chains of various topologies. In cells, poly-Ub is attached to proteins and also exists in unanchored form. Accumulation of un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26364-x
更新日期:2018-05-31 00:00:00
abstract::In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2 phenotype is still poorly unde...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70137-4
更新日期:2020-08-12 00:00:00
abstract::The striped venus (Chamelea gallina) is an important economic resource in the Mediterranean Basin; this species has exhibited a strong quantitative decline in the Adriatic Sea. The aim of this work was to provide a comprehensive view of the biological status of C. gallina to elucidate the bioecological characteristics...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75984-9
更新日期:2020-11-05 00:00:00
abstract::The biochemical abnormalities and oxidative stress during pathogenesis of hepatic fibrosis could lead to alteration of trace elements. We studied the alteration of major trace elements during the pathogenesis of N-nitrosodimethylamine (NDMA)-induced hepatic fibrosis in rats. The biochemical and pathological indices of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37516-4
更新日期:2019-01-24 00:00:00
abstract::In this paper, we study the influence of the fingerprint and sweat on the fingerprint on the friction between the hand and an object. When sweat contacts a finger or an object, it is sometimes easy to pick up the object. In particular, we can see this phenomenon when grasping a thin object such as paper and vinyl. The...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51694-9
更新日期:2019-11-12 00:00:00
abstract::Transverse-tubules (T-tubules) play pivotal roles in Ca2+-induced, Ca2+ release and excitation-contraction coupling in cardiomyocytes. The purpose of this study was to uncover mechanisms where sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a) improved cardiac function through T-tubule regulation during myocardial isch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81570-4
更新日期:2021-01-21 00:00:00
abstract::Graphene oxide is being used in energy, optical, electronic and sensor devices due to its unique properties. However, unlike its counterpart - graphene - the thermal transport properties of graphene oxide remain unknown. In this work, we use large-scale molecular dynamics simulations with reactive potentials to system...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03909
更新日期:2014-01-28 00:00:00
abstract::Across boundary currents, zooplankton are subject to strong oceanographic gradients and hence strong selective pressures. How such gradients interact with the speciation process of pelagic organisms is still poorly understood in the open ocean realm. Here we report on genetic diversity within the pelagic copepod Pleur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56935-5
更新日期:2020-01-24 00:00:00
abstract::The purpose of the study was to assess both anatomic and functional outcomes between short-pulse continuous wavelength and infrared micropulse lasers in the treatment of DME. This was a prospective interventional study from tertiary care eye hospital-King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). Patients...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79699-9
更新日期:2021-01-08 00:00:00
abstract::Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis event leading to release, SNARE proteins provide most of the mechanical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17669
更新日期:2015-12-04 00:00:00
abstract::Human listeners are able to recognize accurately an impressive range of complex sounds, such as musical instruments or voices. The underlying mechanisms are still poorly understood. Here, we aimed to characterize the processing time needed to recognize a natural sound. To do so, by analogy with the "rapid visual seque...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43126-5
更新日期:2019-05-29 00:00:00
abstract::Tench (Tinca tinca L.) is one of the most valued species of the Cyprinidae. This species is commercially important and has been intensively domesticated in recent years. To avoid excessive production losses, the health of farm fish must be maintained. Characterization of the tench gut microbiome can help achieve this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61351-1
更新日期:2020-03-10 00:00:00
abstract::HilD is an AraC-like transcriptional regulator encoded in the Salmonella pathogenicity island 1 (SPI-1), which actives transcription of many genes within and outside SPI-1 that are mainly required for invasion of Salmonella into host cells. HilD controls expression of target genes directly or by acting through distinc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49192-z
更新日期:2019-09-04 00:00:00
abstract::We show how adaptive protocols of quantum and private communication through bosonic Gaussian channels can be simplifed into much easier block versions that involve resource states with finite energy. This is achieved by combining an adaptive-to-block reduction technique devised earlier, based on teleportation stretchi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33332-y
更新日期:2018-10-15 00:00:00
abstract::In the chemical mechanical polishing process of semiconductor manufacturing, the concentration of 'large' particles ([Formula: see text]0.5 μm) in the slurry, which is considerably larger in size than the main abrasives ([Formula: see text] 0.1 μm), is a critical parameter that strongly influences manufacturing defect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71768-3
更新日期:2020-09-07 00:00:00
abstract::Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, common dysfunctional variants of ABCG2, a urate exporter gene also known as BCRP, are revealed to be a major cause of gout/hyperuricemia. Here, we compared the influence of ABCG2 dysfunction on serum uric acid (SUA) lev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05227
更新日期:2014-06-09 00:00:00