Abstract：
:Amplification of liver injury is mediated by macrophages but the signaling by which the macrophage inflammasome enhances liver injury is not completely understood. The CCAAT/Enhancer Binding Protein-β (C/EBPβ) is a critical signaling molecule for macrophages because expression of a dominant inhibitor of C/EBPβ DNA-binding sites or a targeted deletion of C/EBPβ results in impaired macrophage differentiation. We reported that expression of the phosphorylation-mutant C/EBPβ-Glu217, which mimics phosphorylated C/EBPβ-Thr217, was sufficient to confer macrophage survival to Anthrax lethal toxin. Here, using primary hepatocytes, primary liver macrophages, dominant positive and negative transgenic mice of the C/EBPβ-Thr217 phosphoacceptor, macrophage ablation, and an inhibitory peptide of C/EBPβ-Thr217 phosphorylation, we determined that this phosphorylation is essential for the activation of the inflammasome in liver macrophages and for the hepatocyte apoptosis induced by hepatotoxins that results in liver injury. Similar findings were observed in the livers of patients with acute injury induced by Toxic Oil Syndrome.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Buck M,Solis-Herruzo J,Chojkier Mdoi
10.1038/srep24268subject
Has Abstractpub_date
2016-04-12 00:00:00pages
24268issn
2045-2322pii
srep24268journal_volume
6pub_type
杂志文章abstract：:Liquid foams are classified into a dry foam and a wet foam, empirically judging from the liquid fraction or the shape of the gas bubbles. It is known that physical properties such as elasticity and diffusion are different between the dry foam and the wet foam. Nevertheless, definitions of those states have been vague ...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-11-22 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/srep00143
更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-07-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-06 00:00:00
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更新日期：2017-04-07 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-29 00:00:00
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pub_type： 杂志文章
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更新日期：2018-03-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-01-30 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-13 00:00:00
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更新日期：2017-02-15 00:00:00
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pub_type： 杂志文章
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更新日期：2014-07-22 00:00:00
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journal_title：Scientific reports
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更新日期：2016-07-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-09-26 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-15 00:00:00
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journal_title：Scientific reports
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更新日期：2017-09-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-03-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
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更新日期：2020-08-12 00:00:00
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journal_title：Scientific reports
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更新日期：2014-06-13 00:00:00
