Abstract:
:Cardiorenal syndrome, de novo renal pathology arising secondary to cardiac insufficiency, is clinically recognised but poorly characterised. This study establishes and characterises a valid model representative of Type 2 cardiorenal syndrome. Extensive permanent left ventricular infarction, induced by ligation of the left anterior descending coronary artery in Lewis rats, was confirmed by plasma cardiac troponin I, histology and cardiac haemodynamics. Renal function and morphology was assessed 90-days post-ligation when heart failure had developed. The involvement of the paraventricular nucleus was investigated using markers of inflammation, apoptosis, reactive oxygen species and of angiotensin II involvement. An extensive left ventricular infarct was confirmed following coronary artery ligation, resulting in increased left ventricular weight and compromised left ventricular diastolic function and developed pressure. Glomerular filtration was significantly decreased, fractional excretion of sodium and caspase activities were increased and basement membrane thickening, indicating glomerulosclerosis, was evident. Interestingly, angiotensin II receptor I expression and reactive oxygen species levels in the hypothalamic paraventricular nucleus remained significantly increased at 90-days post-coronary artery ligation, suggesting that these hypothalamic changes may represent a novel, valuable pharmacological target. This model provides conclusive morphological, biochemical and functional evidence of renal injury consequent to heart failure, truly representative of Type-2 cardiorenal syndrome.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Harrison JC,Smart SDG,Besley EMH,Kelly JR,Read MI,Yao Y,Sammut IAdoi
10.1038/s41598-020-58071-xsubject
Has Abstractpub_date
2020-01-27 00:00:00pages
1261issue
1issn
2045-2322pii
10.1038/s41598-020-58071-xjournal_volume
10pub_type
杂志文章abstract::Phytoene desaturases catalyse from two to six desaturation reactions on phytoene, generating a large diversity of molecules that can then be cyclised and produce, depending on the organism, many different carotenoids. We constructed a phylogenetic tree of a subset of phytoene desaturases from the CrtI family for which...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77876-4
更新日期:2020-12-03 00:00:00
abstract::The nucleotides guanosine tetraphosphate and pentaphosphate (together known as (p)ppGpp or magic spot) are produced in plant plastids from GDP/GTP and ATP by RelA-SpoT homologue (RSH) enzymes. In the model plant Arabidopsis (p)ppGpp regulates chloroplast transcription and translation to affect growth, and is also impl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54207-w
更新日期:2019-11-27 00:00:00
abstract::The ability to extract the direction of the other's gaze allows us to shift our attention to an object of interest to the other and to establish joint attention. By mapping one's own intentions on the object of joint attention, humans develop a Theory of (the other's) Mind (TOM), a functional sequence possibly disrupt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51783-9
更新日期:2019-10-25 00:00:00
abstract::Pertussis is a highly contagious disease for which prompt, point-of-care diagnosis remains an unmet clinical need. Results from conventional test modalities (nucleic acid detection, serology, and culture) take hours to days. To overcome this challenge, we identified a new biomarker (tracheal colonization factor A, Tcf...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72092-6
更新日期:2020-09-14 00:00:00
abstract::The arrival of the Longobards in Northern Italy in 568 CE marked a period of renewed political stability in the Peninsula after the collapse of the Western Roman Empire. The trajectory of the spread of Longobards in Italy across the Alps and into the South is known from many literary sources. However, their mobility a...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-67480-x
更新日期:2020-07-15 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-69834-x
更新日期:2020-07-29 00:00:00
abstract::The anisotropic hole and electron mobilities in N,N'-3,4,9,10-perylenediimide-1,7-phenoxy (PDIB-2OPh) and N,N'-3,4,9,10-perylenediimide (PDIB) were theoretically predicted using the Marcus-Hush theory. The substituent effect of phenoxy on their mobility rates, absorption spectra, electron affinities, and ionization po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35555
更新日期:2016-10-19 00:00:00
abstract::Bats are the only mammals capable of true, powered flight, which drives an extremely high metabolic rate. The "Free Radical Theory of Ageing" (FTRA) posits that a high metabolic rate causes mitochondrial heteroplasmy and the progressive ageing phenotype. Contrary to this, bats are the longest-lived order of mammals gi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31093-2
更新日期:2018-09-11 00:00:00
abstract::The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16045-6
更新日期:2017-11-16 00:00:00
abstract::Pulsatile motion occurs in the cardiac systolic period and leads to significantly larger displacement of water molecules as it is observed during diffusion weighted image acquisition. Obvious pulsatile motion arises in the brain stem and basal ganglia and might affect the corticospinal tract. So far there is no consen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29525-0
更新日期:2018-07-25 00:00:00
abstract::We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under differe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13865
更新日期:2015-09-10 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-018-20356-7
更新日期:2018-02-02 00:00:00
abstract::Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression in cod. Enzymatic assays employing specific bacterial lysozyme inhibitors provided evidence for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28318
更新日期:2016-06-21 00:00:00
abstract::Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we foc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19442-7
更新日期:2018-01-26 00:00:00
abstract::Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients' quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19074
更新日期:2016-01-08 00:00:00
abstract::Ulvan, which is one of the major structural polysaccharides of the cell walls of green macroalgae, is degraded by ulvan lyases via the β-elimination mechanism with the release of oligosaccharides that have unsaturated 4-deoxy-L-threo-hex-4-enopyranosiduronic acid (∆) at the non-reducing end. These ulvan lyases belong ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32922-0
更新日期:2018-10-02 00:00:00
abstract::Regional abnormalities in brain structure and function, as well as disrupted connectivity, have been found repeatedly in adolescents with conduct disorder (CD). Yet, the large-scale brain topology associated with CD is not well characterized, and little is known about the systematic neural mechanisms of CD. We employe...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep37053
更新日期:2016-11-14 00:00:00
abstract::Ensembles of fcc nickel nanowires have been synthesized with defined mean sizes in the interior of single-wall carbon nanotubes. The method allows the intrinsic nature of single-domain magnets to emerge with large coercivity as their size becomes as small as the exchange length of nickel. By means of X-ray magnetic ci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15033
更新日期:2015-10-13 00:00:00
abstract::We evaluated surgical outcomes of bilateral rectus (BLR) recession in patients with intermittent exotropia who underwent diagnostic monocular occlusion. Records of patients with intermittent exotropia who were preoperatively examined one-hour monocular occlusion and underwent BLR recession were reviewed retrospectivel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64642-9
更新日期:2020-05-08 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-63941-5
更新日期:2020-05-18 00:00:00
abstract::Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73815-5
更新日期:2020-10-07 00:00:00
abstract::Despite technical advances in brain machine interfaces (BMI), for as-yet unknown reasons the ability to control a BMI remains limited to a subset of users. We investigate whether individual differences in BMI control based on motor imagery (MI) are related to differences in MI ability. We assessed whether differences ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24076
更新日期:2016-04-07 00:00:00
abstract::Using analytical expressions for the magnetization textures of thin submicron-sized magnetic cylinders in vortex state, we derive closed-form algebraic expressions for the ensuing small-angle neutron scattering (SANS) cross sections. Specifically, for the perpendicular and parallel scattering geometries, we have compu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25055
更新日期:2016-04-26 00:00:00
abstract::A novel Cobalt Nickle Iron-layered double hydroxide/carbon nanofibres (CoNiFe-LDH/CNFs-0.5) composite was successfully fabricated through an easy in situ growth approach. The morphology and composition of the obtained materials were systematically investigated. When the two derived materials were used for supercapacit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04807-1
更新日期:2017-07-05 00:00:00
abstract::We have designed a versatile and sensitive liquid chromatographic (LC) system, featuring a monolithic trap column and a very narrow (10 μm ID) fused silica open tubular liquid chromatography (OTLC) separation column functionalized with C18-groups, for separating a wide range of molecules (from small metabolites to int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37507
更新日期:2016-11-29 00:00:00
abstract::DNA methylation is an essential epigenetic marker associated with the silencing of gene expression. Although various genome-wide studies revealed aberrantly methylated gene targets as molecular biomarkers for early detection, the survival rate of lung cancer patients is still poor. In order to identify methylation-dri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42573
更新日期:2017-02-15 00:00:00
abstract::Root-knot nematodes (RKNs) are obligate biotrophic parasites that invade plant roots and engage in prolonged and intimate relationships with their hosts. Nematode secretions, some of which have immunosuppressing activity, play essential roles in successful parasitism; however, their mechanisms of action remain largely...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19443
更新日期:2016-01-22 00:00:00
abstract::In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract ("formants"), rather than in the rate of tissue vibration in the sound source ("pitch"). Anatomical constraints on the vocal tract's size render formants honest cues to size in many bird and mammal species, but it i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01948-1
更新日期:2017-05-12 00:00:00
abstract::This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least squares (PLS) models based on full and selected wavelengths suggested by regression coefficient (RC) method were established to predict the f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21130
更新日期:2016-02-17 00:00:00
abstract::Protein structure prediction is a grand challenge. Prediction of protein structures via the representations using backbone dihedral angles has recently achieved significant progress along with the on-going surge of deep neural network (DNN) research in general. However, we observe that in the protein backbone angle pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76317-6
更新日期:2020-11-10 00:00:00