Abstract:
:MicroRNAs play critical role in the development and progression of various diseases. Predicting potential miRNA-disease associations from vast amount of biological data is an important problem in the biomedical research. Considering the limitations in previous methods, we developed Regularized Least Squares for MiRNA-Disease Association (RLSMDA) to uncover the relationship between diseases and miRNAs. RLSMDA can work for diseases without known related miRNAs. Furthermore, it is a semi-supervised (does not need negative samples) and global method (prioritize associations for all the diseases simultaneously). Based on leave-one-out cross validation, reliable AUC have demonstrated the reliable performance of RLSMDA. We also applied RLSMDA to Hepatocellular cancer and Lung cancer and implemented global prediction for all the diseases simultaneously. As a result, 80% (Hepatocellular cancer) and 84% (Lung cancer) of top 50 predicted miRNAs and 75% of top 20 potential associations based on global prediction have been confirmed by biological experiments. We also applied RLSMDA to diseases without known related miRNAs in golden standard dataset. As a result, in the top 3 potential related miRNA list predicted by RLSMDA for 32 diseases, 34 disease-miRNA associations were successfully confirmed by experiments. It is anticipated that RLSMDA would be a useful bioinformatics resource for biomedical researches.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen X,Yan GYdoi
10.1038/srep05501subject
Has Abstractpub_date
2014-06-30 00:00:00pages
5501issn
2045-2322pii
srep05501journal_volume
4pub_type
杂志文章abstract::Aim of this retrospective analysis was to evaluate the survival times after percutaneous irreversible electroporation (IRE) in inoperable liver tumors not amenable to thermal ablation. 71 patients (14 females, 57 males, median age 63.5 ± 10.8 years) with 103 liver tumors were treated in 83 interventions using IRE (Nan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43687
更新日期:2017-03-07 00:00:00
abstract::A new extraordinary application of deoxyribonucleic acid (DNA) thin-solid-film was experimentally explored in the field of ultrafast nonlinear photonics. Optical transmission was investigated in both linear and nonlinear regimes for two types of DNA thin-solid-films made from DNA in aqueous solution and DNA-cetyltrime...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41480
更新日期:2017-01-27 00:00:00
abstract::Modulation of initial burst and long term release from electrospun fibrous mats can be achieved by sandwiching the drug loaded mats between hydrophobic layers of fibrous polycaprolactone (PCL). Ibuprofen (IBU) loaded PCL fibrous mats (12% PCL-IBU) were sandwiched between fibrous polycaprolactone layers during the proc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74885-1
更新日期:2020-10-23 00:00:00
abstract::Due to their immunosuppressive properties, mesenchymal stem cells (MSC) have been evaluated for the treatment of immunological diseases. However, the animal-derived growth supplements utilized for MSC manufacturing may lead to clinical complications. Characterization of alternative media formulations is imperative for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16570
更新日期:2015-11-13 00:00:00
abstract::Phthalates are commonly included as ingredients in personal care products such as cosmetics, shampoos and perfumes. Diethyl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects on males, but effects on females are poorly understood. We designed an integrative and translatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63904-w
更新日期:2020-04-27 00:00:00
abstract::The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored the effects of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13054-3
更新日期:2017-10-06 00:00:00
abstract::Despite technical advances in brain machine interfaces (BMI), for as-yet unknown reasons the ability to control a BMI remains limited to a subset of users. We investigate whether individual differences in BMI control based on motor imagery (MI) are related to differences in MI ability. We assessed whether differences ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24076
更新日期:2016-04-07 00:00:00
abstract::Grading of essential hypertension according to blood pressure (BP) level may not adequately reflect clinical heterogeneity of hypertensive patients. This study was carried out to explore clinical phenotypes in essential hypertensive patients using cluster analysis. This study recruited 513 hypertensive patients and ev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43965
更新日期:2017-03-07 00:00:00
abstract::Coastal zones constitute one of the most heavily populated and developed land zones in the world. Despite the utility and economic benefits that coasts provide, there is no reliable global-scale assessment of historical shoreline change trends. Here, via the use of freely available optical satellite images captured si...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24630-6
更新日期:2018-04-27 00:00:00
abstract::The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a "glymphatic system" where metabolites are removed from the brain's extracellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) along the paravascular spaces (PVS) around cerebral bl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66887-w
更新日期:2020-06-22 00:00:00
abstract::Insecticides are the main method of controlling lepidopteran pests of eucalyptus plantations and those selective to natural enemies, such as the endoparasitoid Palmistichus elaeisis Delvare et LaSalle (Hymenoptera: Eulophidae), are preferable. The objective of this study was to evaluate the selectivity and effects on ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69200-x
更新日期:2020-07-24 00:00:00
abstract::Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22745
更新日期:2016-03-15 00:00:00
abstract::To elude the strength-electrical conductivity trade-off dilemma, a nanostructuring strategy was achieved in microalloyed Al-0.1wt.% Zr conductor by optimizing the processing route, leading to enhanced strength and simultaneously improved electrical conductivity. The nanostructural design involved ultrafine grains with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24527-4
更新日期:2018-04-18 00:00:00
abstract::There is lack of consensus regarding the prognostic significance of primary tumor location of upper tract urothelial carcinoma(UTUC). We performed a meta-analysis to evaluate the impact of primary tumor location on prognosis in patients with UTUC who had undergone radical nephroureterectomy(RNU). We included eligible ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep06361
更新日期:2014-09-15 00:00:00
abstract::Anoectochilus roxburghii and Anoectochilus formasanus are the major species of genus Anoectochilus used in traditional Chinese medicine for their abundant content of flavonoids and some other medicinal constituents. In recent years, their wild resources are gradually exhausted due to over-collection and ecological det...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56821-0
更新日期:2019-12-27 00:00:00
abstract::In a haptic search task, one has to detect the presence of a target among distractors using the sense of touch. A salient target can be detected faster than a non-salient target. However, little is known about the exploration strategies that are used, especially in 3D search tasks where items are held in the hand. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06254
更新日期:2014-09-03 00:00:00
abstract::Pigeon pea is an important legume infested by a plethora of insect pests amongst which gram pod borer Helicoverpa armigera is very prominent. Imparting resistance to this insect herbivore is of global importance in attaining food security. Expression of insecticidal crystal proteins (ICP) in diverse crops has led to i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26358-9
更新日期:2018-06-11 00:00:00
abstract::A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, 'flow-diverter', can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23698
更新日期:2016-03-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-70620-y
更新日期:2020-09-01 00:00:00
abstract::Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07380-9
更新日期:2017-08-08 00:00:00
abstract::Lon is an essential, multitasking AAA(+) protease regulating many cellular processes in species across all kingdoms of life. Altered expression levels of the human mitochondrial Lon protease (hLon) are linked to serious diseases including myopathies, paraplegia, and cancer. Here, we present the first 3D structure of f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33631
更新日期:2016-09-16 00:00:00
abstract::The conformation of the German shepherd dog (GSD) varies considerably within the breed. These differences may result in large variation in the movement and limb loading and undesirable consequences to their musculoskeletal health. This study aimed to investigate the relationship between conformation and biomechanical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73550-x
更新日期:2020-10-15 00:00:00
abstract::During anaerobic digestion (AD) process, process parameters e.g., VFA, pH, COD removal … and kinetic parameters e.g., hydrolysis rate, lag phase and methane production potential… are the important indicator for illustrating AD process performance, however, the AD process performance based on these parameters remains p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09977-6
更新日期:2017-08-24 00:00:00
abstract::Cerebral aneurysms are abnormal focal dilatations of arterial vessel walls with pathological vessel structure alterations. Sudden rupture can lead to a subarachnoid hemorrhage, which is associated with a high mortality. Therefore, the origin of cerebral aneurysms as well as the progression to the point of rupture need...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69222-5
更新日期:2020-07-23 00:00:00
abstract::A novel ignition hohlraum for indirect-drive inertial confinement fusion is proposed, which is named three-axis cylindrical hohlraum (TACH). TACH is a kind of 6 laser entrance holes (LEHs) hohlraum, which is orthogonally jointed of three cylindrical hohlraums. Laser beams are injected through every entrance hole with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34636
更新日期:2016-10-05 00:00:00
abstract::Free standing, atomically thin transition metal dichalcogenides are a new class of ultralightweight nanoelectromechanical systems with potentially game-changing electro- and opto-mechanical properties, however, the energy dissipation pathways that fundamentally limit the performance of these systems is still poorly un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05730-1
更新日期:2017-07-18 00:00:00
abstract::Carbon nanotubes (CNTs) are among the most versatile nanomaterials, but their exploitation is hindered by limited dispersibility, especially in aqueous solvents. Here, we show that AP-LYS, a highly cationic soluble derivative of denatured hen egg lysozyme, is a very effective tool for the unbundling and solubilisation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52701-9
更新日期:2019-11-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58144-x
更新日期:2020-01-21 00:00:00
abstract::Single-wall carbon nanotubes (SWCNTs) and Bi2Te3 nanoplates are very promising thermoelectric materials for energy harvesting. When these two materials are combined, the resulting nanocomposites exhibit high thermoelectric performance and excellent flexibility. However, simple mixing of these materials is not effectiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73808-4
更新日期:2020-10-12 00:00:00
abstract::Zr-based metallic glasses are prepared by quenching supercooled liquid under pressure. These glasses are stable in ambient conditions after decompression. The High Pressure Quenched glasses have a distinct structure and properties. The pair distribution function shows redistribution of the Zr-Zr interatomic distances ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66418-7
更新日期:2020-06-11 00:00:00