Abstract：
:We report on a highly efficient magneto-actuated cancer cell apoptosis method using a biaxial pulsed magnetic field configuration, which maximizes the induced magnetic torque. The light transmissivity dynamics show that the biaxial magnetic field configuration can actuate the magnetic nanoparticles with higher responsiveness over a wide range of frequencies as compared to uniaxial field configurations. Its efficacy was demonstrated in in vitro cell destruction experiments with a greater reduction in cell viability. Magnetic nanoparticles with high aspect ratios were also found to form a triple vortex magnetization at remanence which increases its low field susceptibility. This translates to a larger magneto-mechanical actuated force at low fields and 12% higher efficacy in cell death as compared to low aspect ratio nanoparticles.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wong W,Gan WL,Liu N,Lew WSdoi
10.1038/s41598-017-11279-wsubject
Has Abstractpub_date
2017-09-07 00:00:00pages
10919issue
1issn
2045-2322pii
10.1038/s41598-017-11279-wjournal_volume
7pub_type
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