A new high-resolution melting analysis for the detection and identification of Plasmodium in human and Anopheles vectors of malaria.

abstract：:Progression of age can influence gait characteristics. Previous research has investigated lower extremity joint mechanics between young and elderly people in locomotion, however little is known about whether differences exist between young and middle age people. Ten young healthy subjects (22.8 ± 5.3 years) and ten mi...

journal_title：Scientific reports

authors： Jin L,Hahn ME

更新日期：2019-04-03 00:00:00

abstract：:Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...

journal_title：Scientific reports

authors： Hagag IT,Wight DJ,Bartsch D,Sid H,Jordan I,Bertzbach LD,Schusser B,Kaufer BB

更新日期：2020-07-02 00:00:00

abstract：:WD40 proteins belong to a big protein family with members identified in every eukaryotic proteome. However, WD40 proteins were only reported in a few prokaryotic proteomes. Using WDSP ( http://wu.scbb.pkusz.edu.cn/wdsp/ ), a prediction tool, we identified thousands of prokaryotic WD40 proteins, among which few protein...

journal_title：Scientific reports

authors： Shen C,Du Y,Qiao F,Kong T,Yuan L,Zhang D,Wu X,Li D,Wu YD

更新日期：2018-08-28 00:00:00

abstract：:Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid l...

journal_title：Scientific reports

authors： Nayak S,Sridhara A,Melo R,Richer L,Chee NH,Kim J,Linder V,Steinmiller D,Sia SK,Gomes-Solecki M

更新日期：2016-10-11 00:00:00

abstract：:Metformin is used to treat type 2 diabetes. Metformin activates AMP-activated kinase (AMPK), which may contribute to the action of metformin. Metformin also shows anti-proliferation activity. However, the mechanism is remained unknown. We found that treatment of MCF-7 cells with metformin induced the demethylase activ...

journal_title：Scientific reports

authors： Tanaka Y,Konishi A,Obinata H,Tsuneoka M

更新日期：2019-12-10 00:00:00

abstract：:It has been recently ascribed to several inflammatory cytokines (i.e. TGF-β3, TNF-α, and IL-1) a functional role in regulating Sertoli cell blood-testis barrier (BTB) dynamics. In the testis, IL-6 inhibits meiotic DNA synthesis during the seminiferous epithelium cycle, reduces sperm motility and influences the secreti...

journal_title：Scientific reports

authors： Zhang H,Yin Y,Wang G,Liu Z,Liu L,Sun F

更新日期：2014-03-03 00:00:00

abstract：:To achieve a better understanding of the "vinegar syndrome" phenomenon, which has caused serious damage to triacetyl cellulose-based motion picture films, the white powder obtained from damaged film surfaces was analysed in this study. The powder was found to be soluble in acetone, diethyl ether, dimethylformamide, an...

journal_title：Scientific reports

authors： Takahashi K,Sasaki M,Hayakawa H,Yajima H,Oda Y

更新日期：2021-01-15 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...

journal_title：Scientific reports

authors： Messner A,Werkmeister RM,Seidel G,Stegmann H,Schmetterer L,Aranha Dos Santos V

更新日期：2019-09-20 00:00:00

abstract：:Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...

journal_title：Scientific reports

authors： Inserra A,Choo JM,Lewis MD,Rogers GB,Wong ML,Licinio J

更新日期：2019-04-23 00:00:00

abstract：:A Disintegrin and Metalloproteinase-15 (ADAM15) is a transmembrane protein involved in protein ectodomain shedding, cell adhesion and signalling. We previously cloned and characterised alternatively spliced variants of ADAM15 that differ in their intracellular domains and demonstrated correlation of the expression of ...

journal_title：Scientific reports

authors： Mattern J,Roghi CS,Hurtz M,Knäuper V,Edwards DR,Poghosyan Z

更新日期：2019-08-29 00:00:00

abstract：:Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and effectively regulated, however, regulatory agencies are hampered by a lack of a toolkit to audit ingredient lists, adulterants and constituent activ...

journal_title：Scientific reports

authors： Coghlan ML,Maker G,Crighton E,Haile J,Murray DC,White NE,Byard RW,Bellgard MI,Mullaney I,Trengove R,Allcock RJ,Nash C,Hoban C,Jarrett K,Edwards R,Musgrave IF,Bunce M

更新日期：2015-12-10 00:00:00

abstract：:Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarke...

journal_title：Scientific reports

authors： Kuiper JJ,Beretta L,Nierkens S,van Leeuwen R,Ten Dam-van Loon NH,Ossewaarde-van Norel J,Bartels MC,de Groot-Mijnes JD,Schellekens P,de Boer JH,Radstake TR

更新日期：2017-01-27 00:00:00

abstract：:Without any root contact with the soil, epiphytic bryophytes must experience and explore poor, patchy, and heterogeneous habitats; while, the nitrogen (N) uptake and use strategies of these organisms remain uncharacterized, which obscures their roles in the N cycle. To investigate the N sources, N preferences, and res...

journal_title：Scientific reports

authors： Song L,Lu HZ,Xu XL,Li S,Shi XM,Chen X,Wu Y,Huang JB,Chen Q,Liu S,Wu CS,Liu WY

更新日期：2016-07-27 00:00:00

abstract：:An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Us...

journal_title：Scientific reports

authors： Omardien S,Ter Beek A,Vischer N,Montijn R,Schuren F,Brul S

更新日期：2018-06-14 00:00:00

abstract：:Poor CD4+ T-cell recovery after cART has been associated with skewed T-cell maturation, inflammation and immunosenescence; however, T-cell functionality in those individuals has not been fully characterized. In the present study, we assessed T-cell function by assessing cytokine production after polyclonal, CMV and HI...

journal_title：Scientific reports

authors： Gómez-Mora E,García E,Urrea V,Massanella M,Puig J,Negredo E,Clotet B,Blanco J,Cabrera C

更新日期：2017-09-15 00:00:00

abstract：:Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), ...

journal_title：Scientific reports

authors： van de Wijgert JHHM,Verwijs MC,Agaba SK,Bronowski C,Mwambarangwe L,Uwineza M,Lievens E,Nivoliez A,Ravel J,Darby AC

更新日期：2020-03-03 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are adult multipotent cells that have plasticity and inhabit the stroma of diverse tissues. The potential utility of MSCs has been heavily investigated in the fields of regenerative medicine and cell therapy. However, MSCs represent diverse populations that may depend on the tissue ...

journal_title：Scientific reports

authors： Cho KA,Park M,Kim YH,Woo SY,Ryu KH

更新日期：2017-12-07 00:00:00

abstract：:Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relati...

journal_title：Scientific reports

authors： Napso T,Hung YP,Davidge ST,Care AS,Sferruzzi-Perri AN

更新日期：2019-11-28 00:00:00

abstract：:Soft tissue prostheses such as artificial ear, eye and nose are widely used in the maxillofacial rehabilitation. In this report we demonstrate how to fabricate soft prostheses mold with a low cost desktop 3D printer. The fabrication method used is referred to as Scanning Printing Polishing Casting (SPPC). Firstly the ...

journal_title：Scientific reports

authors： He Y,Xue GH,Fu JZ

更新日期：2014-11-27 00:00:00

abstract：:The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do ...

journal_title：Scientific reports

authors： Nikmaneshi MR,Firoozabadi B,Mozafari A,Munn LL

更新日期：2020-02-20 00:00:00

abstract：:Tuberculosis (TB) is a leading infectious cause of death globally. Drug treatment and vaccination, in particular with Bacillus Calmette-Guérin (BCG), remain the main strategies to control TB. With the emergence of drug resistance, it has been proposed that a combination of TB vaccination with pharmacological treatment...

journal_title：Scientific reports

authors： Prabowo SA,Zelmer A,Stockdale L,Ojha U,Smith SG,Seifert K,Fletcher HA

更新日期：2019-03-19 00:00:00

abstract：:Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our objective was to test whether gliadin, one of the detrimental parts of gluten, would impact the metabolic effects of an obesogenic diet. Mice we...

journal_title：Scientific reports

authors： Zhang L,Andersen D,Roager HM,Bahl MI,Hansen CH,Danneskiold-Samsøe NB,Kristiansen K,Radulescu ID,Sina C,Frandsen HL,Hansen AK,Brix S,Hellgren LI,Licht TR

更新日期：2017-03-16 00:00:00

abstract：:Hydrogen sulfide (H2S) signaling has been considered a key regulator of plant developmental processes and defenses. In this study, we demonstrate that high levels of H2S inhibit auxin transport and lead to alterations in root system development. H2S inhibits auxin transport by altering the polar subcellular distributi...

journal_title：Scientific reports

authors： Jia H,Hu Y,Fan T,Li J

更新日期：2015-02-05 00:00:00

abstract：:Turner Syndrome (TS) is a condition where several genes are affected but the molecular mechanism remains unknown. Identifying the genes that regulate the TS network is one of the main challenges in understanding its aetiology. Here, we studied the regulatory network from manually curated genes reported in the literatu...

journal_title：Scientific reports

authors： Farooqui A,Tazyeen S,Ahmed MM,Alam A,Ali S,Malik MZ,Ali S,Ishrat R

更新日期：2018-07-04 00:00:00

abstract：:Assembly of nanowires into ordered macroscopic structures with new functionalities has been a recent focus. In this Letter, we report a new route for ordering hydrophilic Ag nanowires with high aspect ratio by flowing through a glass capillary. The present glass capillary with well-defined silver nanowire films inside...

journal_title：Scientific reports

authors： Liu JW,Wang JL,Huang WR,Yu L,Ren XF,Wen WC,Yu SH

更新日期：2012-01-01 00:00:00

abstract：:Bleeding risk with antiplatelet therapy is an increasing clinical challenge. However, the inter-individual variation in this risk is poorly understood. We assessed whether the level of plasma creatine kinase, the enzyme that utilizes ADP and phosphocreatine to rapidly regenerate ATP, may modulate bleeding risk through...

journal_title：Scientific reports

authors： Horjus DL,Nieuwland R,Boateng KB,Schaap MC,van Montfrans GA,Clark JF,Sturk A,Brewster LM

更新日期：2014-10-09 00:00:00

abstract：:Brain hypometabolism is a common epilepsy-related finding in both patients and animal models. Fluorodeoxyglucose positron emission tomography studies have shown that recurrent seizures lead to reduced glucose metabolism in certain brain regions, but no studies have definitively determined whether this induces epilepto...

journal_title：Scientific reports

authors： Zhang H,Gao G,Zhang Y,Sun Y,Li H,Dong S,Ma W,Liu B,Wang W,Wu H,Zhang H

更新日期：2017-07-19 00:00:00

abstract：:E5 proteins are amongst the least understood of the Human Papillomavirus (HPV) encoded gene products. They are small, membrane-integrated proteins known to modulate a number of critical host pathways associated with pathogenesis including growth factor receptor signaling and immune evasion. Their role in the virus lif...

journal_title：Scientific reports

authors： Müller M,Wasson CW,Bhatia R,Boxall S,Millan D,Goh GY,Haas J,Stonehouse NJ,Macdonald A

更新日期：2015-08-03 00:00:00

abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...

journal_title：Scientific reports

authors： Liviero F,Scarpa MC,De Stefani D,Folino F,Campisi M,Mason P,Iliceto S,Pavanello S,Maestrelli P

更新日期：2020-09-16 00:00:00