An Ocular Protein Triad Can Classify Four Complex Retinal Diseases.

Abstract:

:Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarkers in 175 ocular fluids to classify four archetypical ocular conditions affecting the retina (age-related macular degeneration, idiopathic non-infectious uveitis, primary vitreoretinal lymphoma, and rhegmatogenous retinal detachment) with one single test. Unsupervised clustering of ocular proteins revealed a classification strikingly similar to the clinical phenotypes of each disease group studied. We developed and independently validated a parsimonious model based merely on three proteins; interleukin (IL)-10, IL-21, and angiotensin converting enzyme (ACE) that could correctly classify patients with an overall accuracy, sensitivity and specificity of respectively, 86.7%, 79.4% and 92.5%. Here, we provide proof-of-concept for molecular profiling as a diagnostic aid for ophthalmologists in the care for patients with retinal conditions.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kuiper JJ,Beretta L,Nierkens S,van Leeuwen R,Ten Dam-van Loon NH,Ossewaarde-van Norel J,Bartels MC,de Groot-Mijnes JD,Schellekens P,de Boer JH,Radstake TR

doi

10.1038/srep41595

subject

Has Abstract

pub_date

2017-01-27 00:00:00

pages

41595

issn

2045-2322

pii

srep41595

journal_volume

7

pub_type

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