Abstract：
:FTY-720 (Fingolimod) was one of the first compounds authorized for the treatment of multiple sclerosis. Among its other activities, this sphingosine analogue enhances exocytosis in neuroendocrine chromaffin cells, altering the quantal release of catecholamines. Surprisingly, the size of chromaffin granules is reduced within few minutes of treatment, a process that is paralleled by the homotypic fusion of granules and their heterotypic fusion with mitochondria, as witnessed by dynamic confocal and TIRF microscopy. Electron microscopy studies support these observations, revealing the fusion of several vesicles with individual mitochondria to form large, round mixed organelles. This cross-fusion is SNARE-dependent, being partially prevented by the expression of an inactive form of SNAP-25. Fused mitochondria exhibit an altered redox potential, which dramatically enhances cell death. Therefore, the cross-fusion of intracellular organelles appears to be a new mechanism to be borne in mind when considering the effect of FTY-720 on the survival of neuroendocrine cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gimenez-Molina Y,García-Martínez V,Villanueva J,Davletov B,Gutiérrez LMdoi
10.1038/s41598-019-55106-wsubject
Has Abstractpub_date
2019-12-05 00:00:00pages
18471issue
1issn
2045-2322pii
10.1038/s41598-019-55106-wjournal_volume
9pub_type
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