Abstract:
:The intermolt crustacean Y-organ (YO) maintains a basal state mediated by pulsatile release of molt inhibiting hormone (MIH), a neuropeptide produced in the eyestalk ganglia, inhibiting YO ecdysteroidogenesis. Reduction of MIH results in YO activation and the animal enters premolt. In the crab, Gecarcinus lateralis, molting was induced by eyestalk ablation (ESA). ESA animals were injected with either rapamycin, an mTOR inhibitor, or DMSO vehicle at Day 0. YOs were harvested at 1, 3, and 7 days post-ESA and processed for high throughput RNA sequencing. ESA-induced increases in mRNA levels of mTOR signaling genes (e.g., mTOR, Rheb, TSC1/2, Raptor, Akt, and S6 kinase) declined following rapamycin treatment. In concert with mTOR inhibition, mRNA levels of ecdysteroid biosynthesis genes (e.g., Nvd, Spo, Sad, Dib, and Phm) were decreased and accompanied by a decrease in hemolymph ecdysteroid titer. By contrast, rapamycin increased the mRNA level of FKBP12, the rapamycin-binding protein, as well as the mRNA levels of genes associated with Wnt and insulin-like growth factor signaling pathways. Many MIH and transforming growth factor-β signaling genes were down regulated in ESA animals. These results indicate that mTOR activity either directly or indirectly controls transcription of genes that drive activation of the YO.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shyamal S,Das S,Guruacharya A,Mykles DL,Durica DSdoi
10.1038/s41598-018-25368-xsubject
Has Abstractpub_date
2018-05-09 00:00:00pages
7307issue
1issn
2045-2322pii
10.1038/s41598-018-25368-xjournal_volume
8pub_type
杂志文章abstract::Drug resistance is one of the leading causes of failed cancer therapy in the treatment of acute myeloid leukemia. Although the mechanisms of resistance are poorly understood, they may be related to the presence of leukemia stem cells (LSCs). Down-regulation of the miR-203 reportedly contributes to oncogenesis and chem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19995
更新日期:2016-02-05 00:00:00
abstract::Haber-Bosch nitrogen (N) has been increasingly used in industrial products, e.g., nylon, besides fertilizer. Massive numbers of species of industrial reactive N (Nr) have emerged and produced definite consequences but receive little notice. Based on a comprehensive inventory, we show that (1) the industrial N flux has...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02579
更新日期:2013-01-01 00:00:00
abstract::The American mink (Neovison vison) is a semiaquatic species of mustelid native to North America. It's an important animal for the fur industry. Many efforts have been made to locate genes influencing fur quality and color, but this search has been impeded by the lack of a reference genome. Here we present the first dr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15169-z
更新日期:2017-11-06 00:00:00
abstract::This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28484-w
更新日期:2018-07-12 00:00:00
abstract::The root system displays a remarkable plasticity that enables plants to adapt to changing environmental conditions. This plasticity is tightly linked to the activity of root apical meristems (RAMs) and to the formation of lateral roots, both controlled by related hormonal crosstalks. In Arabidopsis thaliana, gibberell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38876-1
更新日期:2019-02-20 00:00:00
abstract::Drought during the early vegetation growing season (spring through early summer) is a severe natural hazard in the large cropland over North America. Given the recent increasing severity of climate change manifested as surface warming, there has been a growing interest in how warming affects drought and the prospect o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25932-5
更新日期:2018-05-14 00:00:00
abstract::The circuit complexity of quantum qubit system evolution as a primitive problem in quantum computation has been discussed widely. We investigate this problem in terms of qudit system. Using the Riemannian geometry the optimal quantum circuits are equivalent to the geodetic evolutions in specially curved parametrizatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04044
更新日期:2014-02-10 00:00:00
abstract::Barley is a kind of cereal grass belonging to the family Poaceae. To examine viruses infecting winter barley in Korea, we carried out a comprehensive study of barley RNA viromes using next-generation sequencing (NGS). A total of 110 barley leaf samples from 17 geographical locations were collected. NGS followed by ext...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31671-4
更新日期:2018-09-05 00:00:00
abstract::Basidiomycetes can bioaccumulate high iron contents, but there are few studies on iron availability from the mycelial biomass in order to support their use as an iron-enriched fungal food. This study aimed to evaluate the in vitro iron bioaccumulation and availability in the mycelial biomass of edible and medicinal ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69699-0
更新日期:2020-07-30 00:00:00
abstract::Pre-clinical monitoring of tumor growth and identification of distal metastasis requires a balance between accuracy and expediency. Bioluminescence imaging (BLI) is often used to track tumor growth but is primarily limited to planar 2-dimensional (2D) imaging. Consistent subject placement within a standard top-mounted...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21668-4
更新日期:2018-02-20 00:00:00
abstract::Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52332-0
更新日期:2019-11-04 00:00:00
abstract::The extensive redundancy in the use of invasion ligands by Plasmodium falciparum, and its unique ability to switch between invasion pathways have hampered vaccine development. P. falciparum strains Dd2 and W2mef have been shown to change from sialic acid (SA)-dependent to SA-independent phenotypes when selected on neu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24218-0
更新日期:2018-04-10 00:00:00
abstract::Earth's orbital variations on timescales of 104-105 years, known as Milankovitch cycles, have played a critical role in pacing climate change and ecosystem dynamics, through glacial and/or monsoon dynamics. However, the climatic and biotic consequences of these cycles on much longer (~ 107 years) timescales remain unc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68542-w
更新日期:2020-07-23 00:00:00
abstract::The integral membrane-bound Nrf1 transcription factor fulfils important functions in maintaining cellular homeostasis and organ integrity, but how it is controlled vectorially is unknown. Herein, creative use of Gal4-based reporter assays with protease protection assays (GRAPPA), and double fluorescence protease prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02006
更新日期:2013-01-01 00:00:00
abstract::Individuals with lower limb amputation need a secure suspension system for their prosthetic devices. A new coupling system was developed that is capable of suspending the prosthesis. The system's safety is ensured through an acoustic alarm system. This article explains how the system works and provides an in vivo eval...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02270
更新日期:2013-01-01 00:00:00
abstract::This corrects the article DOI: 10.1038/srep09989. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/srep46956
更新日期:2018-03-19 00:00:00
abstract::Currently, exercise-based cardiac rehabilitation (CR) is the only recommended secondary prevention strategy for cardiac patients that attempts to tackle stress and psychosocial wellbeing, but it is under-utilized and lacks a comprehensive curriculum for this purpose; hence there is a critical gap to address psychosoci...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-54932-2
更新日期:2019-12-05 00:00:00
abstract::Niemann-Pick type C1 (NPC1) disease is a rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range of clinical phenotypes and hence diagnosis remains a challenge. In view of these difficulties, the search for a novel, NPC1-specific biomarker (or set of biomarkers) is a topic o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06264-2
更新日期:2017-07-24 00:00:00
abstract::The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multiple transient and subtly discriminated interactions with diverse bindin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36622
更新日期:2016-11-09 00:00:00
abstract::A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure and an UHPLC-ultrahigh definition-Q-TOF-MS based sphingolipidomic approach. A total of 43 sphingoid bases and 303 ceramides were identified from wild Cordycep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38641
更新日期:2016-12-14 00:00:00
abstract::Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. The basic helix-loop-helix transcription factor Hand2, which is conserved among jawed vertebrates, is expressed in the neural crest in the mandibula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28405
更新日期:2016-06-22 00:00:00
abstract::Crossmodal studies have reported not only facilitatory but also inhibitory perceptual interactions. For instance, tactile stimulation to the index finger of a hand leads to the degradation of visual discrimination performance (touch-induced visual suppression, TIVS). It has been suggested that the magnitude of TIVS de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35302-w
更新日期:2018-11-19 00:00:00
abstract::The plant hormone abscisic acid (ABA) and the jasmonic acid related-compound 12-oxo-phytodienoic acid (OPDA) play crucial roles in seed development, dormancy, and germination. However, a lack of suitable techniques for visualising plant hormones has restricted the investigation of their biological mechanisms. In the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42977
更新日期:2017-02-17 00:00:00
abstract::Random lasers consisting of slab waveguides with two-dimensional disordered wrinkling patterns that act as scattering resonators are reported. As active material 2,2',7,7'-tetraphenyl-9,9'-spirobifluorene is used which is sandwiched between an oxidized silicon wafer and a cladding with higher glass transition temperat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59236-4
更新日期:2020-02-12 00:00:00
abstract::Arthroplasty is a surgical procedure to restore the function of the joint of patient suffering from knee osteoarthritis. However, postoperative functional deficits are reported even after a rehabilitation program. In order to determine the origin of functional deficits of patient suffering from knee osteoarthritis and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62146-0
更新日期:2020-03-24 00:00:00
abstract::This study investigated interactive effects of CYP2B6 genotypes and liver metastasis on the prognosis of metastatic breast cancer patients who received combined chemotherapy of docetaxel and thiotepa. Totally 153 patients were retrospectively genotyped rs8192719 (c.1294 + 53C > T) and rs2279343 (c.785A > G). Kaplan-Me...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep16775
更新日期:2015-11-25 00:00:00
abstract::Attending a location in space facilitates responses to targets at that location when the time between cue and target is short. Certain types of exogenous cues - such as sudden peripheral onsets - have been described as reflexive and automatic. Recent studies however, have been showing many cases where exogenous cues a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31633-w
更新日期:2018-09-05 00:00:00
abstract::Known γ-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identified as direct inhibitors of γ-secretase. To search for bioactive mol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16541
更新日期:2015-11-16 00:00:00
abstract::Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could significantly decrease adenoviral tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00376-5
更新日期:2017-03-24 00:00:00
abstract::Our understanding of innate immune responses in human rectal mucosal tissues (RM) and their contributions to promoting or restricting HIV transmission is limited. We defined the RM composition of innate and innate-like cell subsets, including plasmacytoid dendritic cells; CD1c + myeloid DCs; neutrophils; macrophages; ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76976-5
更新日期:2020-11-19 00:00:00