Abstract：
:Biomedical researchers often encounter the large-p-small-n situations-a great number of variables are measured/recorded for only a few subjects. The authors propose a fuzzy permutation method to address the multiple testing problem for small sample size studies. The method introduces fuzziness into standard permutation analysis to produce randomized p-values, which are then converted into q-values for false discovery rate controls. Simple algebra shows that the fuzzy permutation method is at least as powerful as the standard permutation method under any alternative. Monte-Carlo simulations show that the proposed method has desirable statistical properties whether the study variables are normally or non-normally distributed. A real dataset is analyzed to illustrate its use. The proposed fuzzy permutation method is recommended for use in the large-p-small-n settings.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yang YH,Lin WY,Lee WCdoi
10.1038/srep28507subject
Has Abstractpub_date
2016-06-22 00:00:00pages
28507issn
2045-2322pii
srep28507journal_volume
6pub_type
杂志文章abstract：:Receptor trafficking is pivotal for the temporal and spatial control of GPCR signaling and is regulated by multiple cellular proteins. We provide evidence that GPCRs interact with 14-3-3 signal adaptor/scaffold proteins and that this interaction regulates receptor trafficking in two ways. We found GPCR/14-3-3 interact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47478-w
更新日期：2019-08-01 00:00:00
abstract：:The physiological roles of the protease inhibitor SERPINB3 (SB3) are still largely unknown. The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model. Two colonies of mice (123 transgenic for SB3 and 148 C57BL/6J controls) have been studied. Transgenic (TG) mice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03056
更新日期：2013-10-28 00:00:00
abstract：:Reconstructing diet is critical to understanding hominin adaptations. Isotopic and functional morphological analyses of early hominins are compatible with consumption of hard foods, such as mechanically-protected seeds, but dental microwear analyses are not. The protective shells surrounding seeds are thought to induc...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-019-57403-w
更新日期：2020-01-17 00:00:00
abstract：:Understanding the phylogeography and genetic structure of populations and the processes responsible of patterns therein is crucial for evaluating the vulnerability of marine species and developing management strategies. In this study, we explore how past climatic events and ongoing oceanographic and demographic proces...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33269
更新日期：2016-09-15 00:00:00
abstract：:Climate change and human activity are dooming species at an unprecedented rate via a plethora of direct and indirect, often synergic, mechanisms. Among these, primary extinctions driven by environmental change could be just the tip of an enormous extinction iceberg. As our understanding of the importance of ecological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35068-1
更新日期：2018-11-13 00:00:00
abstract：:Functional neuroimaging, using genetically-encoded Ca2+ sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological profiling. Here we use zebrafish larvae with pan-neuronal expression of GCaMP6s, combined with light...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06646-6
更新日期：2017-07-26 00:00:00
abstract：:An isolated black yeast-like strain was obtained from radiation-polluted soil collected from Xinjiang province in northwest China. On the basis of ITS and LSU rDNA sequence analysis, in combination with the colony morphology and phenotypic properties, the isolated strain was revealed to represent a novel variety of Au...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15489-0
更新日期：2017-12-14 00:00:00
abstract：:In recent years, there has been an impressively fast technological progress in the development of highly efficient lead halide perovskite solar cells. However, the stability of perovskite films and respective solar cells is still an open point of concern and calls for advanced characterization methods. In this work, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35973
更新日期：2016-10-27 00:00:00
abstract：:Antibiotics are unable to remove biofilms from surgical implants. This high antibiotic tolerance is related to bacterial persisters, a sub-population of bacteria phenotypically tolerant to antibiotics secondary to a reduced metabolic state. WLBU2 is an engineered cationic amphipathic peptide designed to maximize antim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17780-6
更新日期：2017-12-22 00:00:00
abstract：:Brain tumors are fast proliferating and destructive within the brain microenvironment. Effective chemotherapeutic strategies are currently lacking which combat this deadly disease curatively. The glioma-specific chloride ion channel represents a specific target for therapy. Chlorotoxin (CTX), a peptide derived from sc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19799
更新日期：2016-02-02 00:00:00
abstract：:Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes during Ig gene diversification suggest participation of AID in epigenetic regul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07380-9
更新日期：2017-08-08 00:00:00
abstract：:In a previous study, we demonstrated that topical D-beta-hydroxybutyrate ameliorates corneal epithelial erosion and superficial punctate keratopathy in a rat model of dry eye disease. In the current investigation, we performed a prospective, randomized, multicentre, double-blind, placebo-controlled study to assess the...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/srep20855
更新日期：2016-02-11 00:00:00
abstract：:Vocal expression of emotions has been suggested to be conserved throughout evolution. However, since vocal indicators of emotions have never been compared between closely related species using similar methods, it remains unclear whether this is the case. Here, we investigated vocal indicators of emotional valence (neg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09437-1
更新日期：2017-08-18 00:00:00
abstract：:The fatty acid (FA) profile has a considerable impact on the nutritional and technological quality of milk and dairy products. The molecular mechanism underlying the regulation of fat metabolism in bovine mammary gland have been not completely elucidated. We conducted genome-wide association studies (GWAS) across 65 m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17434-7
更新日期：2017-12-11 00:00:00
abstract：:To understand the mechanisms of male sterility in cotton (Gossypium spp.), combined histological, biochemical and transcription analysis using RNA-Seq was carried out in the anther of the single-gene recessive genic male sterility system of male sterile line 1355A and male fertile line 1355B, which are near-isogenic l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09608
更新日期：2015-06-05 00:00:00
abstract：:Monanchoxymycalin C (MomC) is a new marine pentacyclic guanidine alkaloid, recently isolated from marine sponge Monanchora pulchra by us. Here, anticancer activity and mechanism of action was investigated for the first time using a human prostate cancer (PCa) model. MomC was active in all PCa cell lines at low micromo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69751-z
更新日期：2020-08-06 00:00:00
abstract：:Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies. However, the precise mechanisms underlying this effect remain elusive. Here we assessed the hypothesis that TRPA1 is activated by mechanica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30534-2
更新日期：2018-08-13 00:00:00
abstract：:Recently, a new technique was developed for non-catalytically mixing microdroplets. In this method, an alternating-current (AC) electric field is used to promote the antigen-antibody reaction within the microdroplet. Previously, this technique has only been applied to histological examinations of flat structures, such...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15371
更新日期：2015-10-19 00:00:00
abstract：:Marine Fungi are potent secondary metabolite producers. However, limited genetic information are available their biosynthetic gene clusters (BGCs) and their biotechnological applications. To overcome this lack of information, herein, we used next-generation sequencing methods for genome sequencing of two marine fungi,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28473-z
更新日期：2018-07-05 00:00:00
abstract：:Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16823-2
更新日期：2017-11-28 00:00:00
abstract：:Sleep problems are considered a core symptom of depression. However, there is little information about the comorbidity of sleep problems and depression in low- and middle-income countries (LMICs), and whether sleep problems with depression confer additional risk for decrements in health compared to sleep problems alon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48334-7
更新日期：2019-08-19 00:00:00
abstract：:Fuelled by a desire for greater connectivity, networked systems now pervade our society at an unprecedented level that will affect it in ways we do not yet understand. In contrast, nature has already developed efficient networks that can instigate rapid response and consensus when key elements are stimulated. We prese...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53942-4
更新日期：2019-11-26 00:00:00
abstract：:For the first time, a design of a "deflecting elastic prism" is proposed and implemented for waves in a chiral medium. A novel model of an elastic lattice connected to a non-uniform system of gyroscopic spinners is designed to create a unidirectional wave pattern, which can be diverted by modifying the arrangement of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00054-6
更新日期：2017-01-31 00:00:00
abstract：:Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the disco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45222-y
更新日期：2019-06-19 00:00:00
abstract：:Cancer stem cells play an important role on tumor progression. Biomarkers of stem cell property and their relationship to extranodal involvement of malignant lymphocytes are undefined in diffuse large B-cell lymphoma (DLBCL). Here we showed that junctional adhesion molecule-A (JAM-A) was highly expressed in DLBCL pati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07964-5
更新日期：2017-08-07 00:00:00
abstract：:Phytoplasmas (class, Mollicutes) are insect-transmissible and plant-pathogenic bacteria that multiply intracellularly in both plants and insects through host switching. Our previous study revealed that phytoplasmal sigma factor rpoD of OY-M strain (rpoDOY) could be a key regulator of host switching, because the expres...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11893
更新日期：2015-07-07 00:00:00
abstract：:Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its dysregulation is implicated in both ageing and age-associated diseases in human. Cross-tissue variability in splicing further complicates its links to age-associated phenotypes and elucidating these links requires a compreh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29086-2
更新日期：2018-07-19 00:00:00
abstract：:A generalization of the Raman scattering (RS) spectrum, the Raman excitation map (REM) is a hyperspectral two-dimensional (2D) data set encoding vibrational spectra, electronic spectra and their coupling. Despite the great potential of REM for optical sensing and characterization with remarkable sensitivity and select...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65757-9
更新日期：2020-06-08 00:00:00
abstract：:Colletotrichum infects diverse hosts, including tea plants, and can lead to crop failure. Numerous studies have reported that biological processes are involved in the resistance of tea plants to Colletotrichum spp. However, the molecular and biochemical responses in the host during this interaction are unclear. Cuttin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69729-x
更新日期：2020-07-30 00:00:00
abstract：:The FGF receptor signaling pathway is recurrently involved in the leukemogenic processes. Oncogenic fusions of FGFR1 with various fusion partners were described in myeloid proliferative neoplasms, and overexpression and mutations of FGFR3 are common in multiple myeloma. In addition, fibroblast growth factors are abund...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38169-z
更新日期：2019-02-12 00:00:00
