Abstract：
:Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the discovery of potent antifungal agents against human pathologies, we embarked upon developing chemometric approach coupled with statistical design to unravel the origin of the anticandidal potential of a set of 66 essential oils (EOs). EOs were analyzed by GC-MS and tested against Candida albicans and C. parapsilosis (Minimal Inhibitory Concentration, MIC). An Orthogonal Partial Least Square (OPLS) analysis allowed us to identify six molecules presumably responsible for the anticandidal activity of the oils: (Z)-ligustilide, eugenol, eugenyl acetate, citral, thymol, and β-citronellol. These compounds were combined following a full factorial experimental design approach in order to optimize the anticandidal activity and selectivity index (SI = IC50(MRC5 cells)/MIC) through reconstituted mixtures. (Z)-Ligustilide and citral were the most active compounds, while (Z)-ligustilide and eugenol were the two main factors that most contributed to the increase of the SI. These two terpenes can, therefore, be used to construct bioinspired synergistic anticandidal mixtures.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rodrigues AMS,Eparvier V,Odonne G,Amusant N,Stien D,Houël Edoi
10.1038/s41598-019-45222-ysubject
Has Abstractpub_date
2019-06-19 00:00:00pages
8729issue
1issn
2045-2322pii
10.1038/s41598-019-45222-yjournal_volume
9pub_type
杂志文章abstract：:The objective of this study was to examine whether shorter leukocyte telomere length (LTL) is associated with more rapid pulmonary function decline in a longitudinal study of World Trade Center (WTC) responders. WTC responders (N = 284) participating in a monitoring study underwent blood sampling and were followed pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44625-1
更新日期：2019-05-31 00:00:00
abstract：:One of the challenges that plasma research encounters is how to generate a large-scale plasma plume at atmospheric pressure. Through utilizing a third electrode biased by a direct-current voltage, a longer plasma plume is generated by a plasma jet in dielectric barrier discharge configurations. Results indicate that t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35653
更新日期：2016-10-19 00:00:00
abstract：:Somatic copy number alterations (SCNAs) affecting oncogenic drivers have a firmly established role in promoting cancer. However, no agreed-upon standard exists for calling locus-specific amplifications and deletions in each patient sample. Here, we report the correlative analysis of copy number amplitude and length wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19649
更新日期：2016-01-20 00:00:00
abstract：:Tyrosinase efficiently catalyzes the ortho-hydroxylation of monophenols and the oxidation of diphenols without any additional cofactors. Although it is of significant interest for the biosynthesis of catechol derivatives, the rapid catechol oxidase activity and inactivation of tyrosinase have hampered its practical ut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17635-0
更新日期：2017-12-08 00:00:00
abstract：:High-throughput sequencing was applied to analyze the effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichthys molitrix. Silver carps were exposed to two cyanobacteria species (toxic and non-toxic) for RNA-seq and miRNA-seq analysis. RNA-seq revealed that the liver tissue contained 105,379 unigene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10335-9
更新日期：2017-09-05 00:00:00
abstract：:With the increasing amount of research work in surface studies, a more effective method of producing patterned microstructures is highly desired due to the geometric limitations and complex fabricating process of current techniques. This paper presents an efficient and cost-effective method to generate customizable mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21621
更新日期：2016-02-23 00:00:00
abstract：:The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, particularly for cell therapeutics including bioartificial liver systems (BALs). Using serum-free fully-defined culture medium formulations, we measur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02735
更新日期：2013-01-01 00:00:00
abstract：:The use of postmastectomy radiation therapy (PMRT) has been recommended for patients with 4 or more positive lymph nodes, however, its role in patients with 1-3 positive lymph nodes remains unclear. The purpose of this study is to evaluate oncological outcomes for breast cancer patients with T1-2 tumors and 1-3 positi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66495-8
更新日期：2020-06-18 00:00:00
abstract：:Neuroblastoma is the most common and deadly childhood tumor. Relapsed or refractory neuroblastoma has a very poor prognosis despite recent treatment advances. To investigate genomic alterations associated with relapse and therapy resistance, whole-genome sequencing was performed on diagnostic and relapsed lesions toge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78370-7
更新日期：2020-12-31 00:00:00
abstract：:In unpredictable environments in which reliable cues for predicting environmental variation are lacking, a diversifying bet-hedging strategy for diapause exit is expected to evolve, whereby only a portion of diapausing forms will resume development at the first occurrence of suitable conditions. This study focused on ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77727-2
更新日期：2020-12-07 00:00:00
abstract：:We sought to investigate the prevalence, functional characteristics, and clinical significance of right ventricular (RV) involvement in patients with hypertrophic cardiomyopathy (HCM). A total of 256 patients with HCM who underwent both cardiac magnetic resonance (CMR) imaging and transthoracic echocardiography within...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78945-4
更新日期：2020-12-14 00:00:00
abstract：:This paper illustrates the potential for seasonal prediction of wind and solar energy resources through a case study in the Yangtze River estuary. Sea surface temperature and geopotential height-based climate predictors, each with high correlation to ensuing seasonal wind speed and solar radiation at the Baoshan weath...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65281-w
更新日期：2020-05-25 00:00:00
abstract：:Transition metal oxides potentially present higher specific capacities than the current anodes based on carbon, providing an increasing energy density as compared to commercial Li-ion batteries. However, many parameters could influence the performance of the batteries, which depend on the processing of the electrode m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62505-x
更新日期：2020-03-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-14858-z
更新日期：2017-11-07 00:00:00
abstract：:Barley (Hordeum vulgare L.) produces five leucine-derived hydroxynitrile glucosides, potentially involved in alleviating pathogen and environmental stresses. These compounds include the cyanogenic glucoside epiheterodendrin. The biosynthetic genes are clustered. Total hydroxynitrile glucoside contents were previously ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41884-w
更新日期：2019-04-05 00:00:00
abstract：:Period circadian clock (Per) genes Per1 and Per2 have essential roles in circadian oscillation. In this study, we identified a new role of Per1-Per2 cooperation, and its mechanism, using our new experimental methods. Under constant light conditions, the period length of Per1 and Per2 knockout mice depended on the copy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32769
更新日期：2016-09-09 00:00:00
abstract：:Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways relevant to disease are not well understood. Using air-liquid interface cultures of primary human bronchial epithe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57755-8
更新日期：2020-01-22 00:00:00
abstract：:Prenylated indole diketopiperazine (DKP) alkaloids are important bioactive molecules or their precursors. In the context of synthetic biology, efficient means for their biological production would increase their chemical diversification and the discovery of novel bioactive compounds. Here, we prove the suitability of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45519-y
更新日期：2019-06-25 00:00:00
abstract：:Rice is the most important crop in the world, acting as the staple food for over half of the world's population. The evolutionary relationships of cultivated rice and its wild relatives have remained contentious and inconclusive. Here we report on the use of whole chloroplast sequences to elucidate the evolutionary an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13957
更新日期：2015-09-10 00:00:00
abstract：:Age-related hearing loss (ARHI) is the most common sensory disorder in the elderly. Although telomere attrition has been shown as a determinant in the pathobiology of various age-related diseases, it remains unknown whether telomere length is associated with ARHI. We hypothesized that decreased leukocyte telomere leng...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10680-9
更新日期：2017-08-31 00:00:00
abstract：:The interaction between active element Zr and W damages the W fibers and the interface and decreases the mechanical properties, especially the tensile strength of the W fibers reinforced Zr-based bulk metallic glass composites (BMGCs). From the viewpoint of atomic interaction, the W-Zr interaction can be restrained by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08967
更新日期：2015-03-11 00:00:00
abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78061-3
更新日期：2020-12-01 00:00:00
abstract：:The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study mTOR cellular distribution and protein-protein co-localisation in human skeletal muscle in the basal state as well as immediately, 1 and 3 h after an acute bout o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05483-x
更新日期：2017-07-10 00:00:00
abstract：:With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection. Habitat selection and variation in either occurrence or strength of functional responses (i.e. how selection changes with availability) have given new insigh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23111-0
更新日期：2018-03-23 00:00:00
abstract：:GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl-] concentration, which in adult depends on neuron specific K+-Cl- cotransporter-2 (KCC2). Previous studies have shown that KCC2 was downregulated in both epileptic patients and various epileptic animal models. However, the tem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00196-7
更新日期：2017-03-13 00:00:00
abstract：:Archaea are unique microorganisms that are present in ecological niches of high temperature, pH and salinity. A total of 157 archaea were obtained from thirteen sediment, water and rhizospheric soil samples collected from Rann of Kutch, Gujarat, India. With an aim to screen phosphate solubilizing archaea, a new medium...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12293
更新日期：2015-07-28 00:00:00
abstract：:Late endothelial progenitor cells (LEPCs) are derived from mononuclear cells (MNCs) and are thought to directly incorporate into blood vessels and differentiate into mature endothelial cells (ECs). Using transcriptome and proteome analysis, we identified distinctive LEPC profiles and found that Hedgehog-interacting pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12571-5
更新日期：2017-09-29 00:00:00
abstract：:Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The 'dogma' is that IgE molecules merely sensitise mast cells by binding FcεRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell activation. However, certain monoclonal IgE antibodies have been sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09538
更新日期：2015-04-20 00:00:00
abstract：:Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58548-9
更新日期：2020-02-03 00:00:00
abstract：:In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to a delicate balance betwe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16567
更新日期：2015-11-16 00:00:00
