Long-range inputome of cortical neurons containing corticotropin-releasing hormone.

abstract：:The full length human histone 3 lysine 4 demethylase KDM5B (PLU-1/Jarid1B) has been studied using Hydrogen/Deuterium exchange mass spectrometry, homology modelling, sequence analysis, small angle X-ray scattering and electron microscopy. This first structure on an intact multi-domain Jumonji histone demethylase reveal...

journal_title：Scientific reports

authors： Dorosz J,Kristensen LH,Aduri NG,Mirza O,Lousen R,Bucciarelli S,Mehta V,Sellés-Baiget S,Solbak SMØ,Bach A,Mesa P,Hernandez PA,Montoya G,Nguyen TTTN,Rand KD,Boesen T,Gajhede M

更新日期：2019-03-11 00:00:00

abstract：:The end-Triassic is characterized by one of the largest mass extinctions in the Phanerozoic, coinciding with major carbon cycle perturbations and global warming. It has been suggested that the environmental crisis is linked to widespread sill intrusions during magmatism associated with the Central Atlantic Magmatic Pr...

journal_title：Scientific reports

authors： Heimdal TH,Svensen HH,Ramezani J,Iyer K,Pereira E,Rodrigues R,Jones MT,Callegaro S

更新日期：2018-01-09 00:00:00

abstract：:Antimicrobial resistance (AMR) is a major public health threat. Plasmids are able to transfer AMR genes among bacterial isolates. Whole genome sequencing (WGS) is a powerful tool to monitor AMR determinants. However, plasmids are difficult to reconstruct from WGS data. This study aimed to improve the characterization,...

journal_title：Scientific reports

authors： Berbers B,Saltykova A,Garcia-Graells C,Philipp P,Arella F,Marchal K,Winand R,Vanneste K,Roosens NHC,De Keersmaecker SCJ

更新日期：2020-03-09 00:00:00

abstract：:Intraluminal thrombus is a consistent feature of human abdominal aortic aneurysm (AAA). Coagulation factor Xa (FXa) catalyses FII to thrombin (FIIa). We examined the effect of FXa/FIIa inhibition on experimental aortic aneurysm in apolipoprotein E-deficient (ApoE-/-) mice infused with angiotensin II (AngII). The conce...

journal_title：Scientific reports

authors： Moran CS,Seto SW,Krishna SM,Sharma S,Jose RJ,Biros E,Wang Y,Morton SK,Golledge J

更新日期：2017-02-21 00:00:00

abstract：:Osteoporosis is the most common age-related bone disease worldwide and is usually clinically asymptomatic until the first fracture happens. MicroRNAs are critical molecular regulators in bone remodelling processes and are stabilised in the blood. The aim of this project was to identify circulatory microRNAs associated...

journal_title：Scientific reports

authors： Mandourah AY,Ranganath L,Barraclough R,Vinjamuri S,Hof RV,Hamill S,Czanner G,Dera AA,Wang D,Barraclough DL

更新日期：2018-05-30 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Es...

journal_title：Scientific reports

authors： Shepelev NM,Mariasina SS,Mantsyzov AB,Malyavko AN,Efimov SV,Petrova OA,Rodina EV,Zvereva MI,Dontsova OA,Polshakov VI

更新日期：2020-07-06 00:00:00

abstract：:Cas13 endonuclease activity depends on the RNA local secondary structure with strong preference for single-stranded (SS) regions. Hence, it becomes indispensable to identify the SS regions for effective Cas13 mediated RNA knockdown. We herein present rational gRNA design by integrating experimental structure-seq data ...

journal_title：Scientific reports

authors： Bandaru S,Tsuji MH,Shimizu Y,Usami K,Lee S,Takei NK,Yoshitome K,Nishimura Y,Otsuki T,Ito T

更新日期：2020-07-14 00:00:00

abstract：:Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function and is implicated in hippocampal neurogenesis but the cellular source of Shh in the hippocampus remains ill defined. Here, we ...

journal_title：Scientific reports

authors： Gonzalez-Reyes LE,Chiang CC,Zhang M,Johnson J,Arrillaga-Tamez M,Couturier NH,Reddy N,Starikov L,Capadona JR,Kottmann AH,Durand DM

更新日期：2019-11-22 00:00:00

abstract：:Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activ...

journal_title：Scientific reports

authors： Lee TY,Chang CC,Lu WJ,Yen TL,Lin KH,Geraldine P,Li JY,Sheu JR

更新日期：2017-01-05 00:00:00

abstract：:Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathoge...

journal_title：Scientific reports

authors： Delafont V,Samba-Louaka A,Cambau E,Bouchon D,Moulin L,Héchard Y

更新日期：2017-04-10 00:00:00

abstract：:Bi-phasic or diauxic growth is often observed when microbes are grown in a chemically defined medium containing two sugars (for example glucose and lactose). Typically, the two growth stages are separated by an often lengthy phase of arrested growth, the so-called lag-phase. Diauxic growth is usually interpreted as an...

journal_title：Scientific reports

authors： Chu D,Barnes DJ

更新日期：2016-04-29 00:00:00

abstract：:Resistant starch (RS) has been reported to reduce body fat in obese mice. However, this effect has not been demonstrated in humans. In this study, we tested the effects of RS in 19 volunteers with normal body weights. A randomized, double-blinded and crossover design clinical trial was conducted. The study subjects we...

journal_title：Scientific reports

authors： Zhang L,Ouyang Y,Li H,Shen L,Ni Y,Fang Q,Wu G,Qian L,Xiao Y,Zhang J,Yin P,Panagiotou G,Xu G,Ye J,Jia W

更新日期：2019-03-20 00:00:00

abstract：:Differential host responses may be critical determinants of distinct pathologies of West Nile virus (WNV) NY99 (pathogenic) and WNV Eg101 (non-pathogenic) strains. We employed RNA-seq technology to analyze global differential gene expression in WNV-infected mice brain and to identify the host cellular factors leading ...

journal_title：Scientific reports

authors： Kumar M,Belcaid M,Nerurkar VR

更新日期：2016-05-23 00:00:00

abstract：:Bacterial lipopolysaccharides (LPS) activate the TRPA1 cation channels in sensory neurons, leading to acute pain and inflammation in mice and to aversive behaviors in fruit flies. However, the precise mechanisms underlying this effect remain elusive. Here we assessed the hypothesis that TRPA1 is activated by mechanica...

journal_title：Scientific reports

authors： Startek JB,Talavera K,Voets T,Alpizar YA

更新日期：2018-08-13 00:00:00

abstract：:Aldehyde-oxidase-4 (AOX4) is one of the mouse aldehyde oxidase isoenzymes and its physiological function is unknown. The major source of AOX4 is the Harderian-gland, where the enzyme is characterized by daily rhythmic fluctuations. Deletion of the Aox4 gene causes perturbations in the expression of the circadian-rhyth...

journal_title：Scientific reports

authors： Terao M,Barzago MM,Kurosaki M,Fratelli M,Bolis M,Borsotti A,Bigini P,Micotti E,Carli M,Invernizzi RW,Bagnati R,Passoni A,Pastorelli R,Brunelli L,Toschi I,Cesari V,Sanoh S,Garattini E

更新日期：2016-07-26 00:00:00

abstract：:We aimed to assess feasibility of a support vector machine (SVM) texture classifier to discriminate pathologic infiltration patterns from the normal bone marrows in MRI. This retrospective study included 467 cases, which were split into a training (n = 360) and a test set (n = 107). A sagittal T1-weighted lumbar spina...

journal_title：Scientific reports

authors： Hwang EJ,Jung JY,Lee SK,Lee SE,Jee WH

更新日期：2019-04-15 00:00:00

abstract：:Diagnostic test accuracy of the loop-mediated isothermal amplification (LAMP) assay for culture proven tuberculosis is unclear. We searched electronic databases for both cohort and case-control studies that provided data to calculate sensitivity and specificity. The index test was any LAMP assay including both commerc...

journal_title：Scientific reports

authors： Nagai K,Horita N,Yamamoto M,Tsukahara T,Nagakura H,Tashiro K,Shibata Y,Watanabe H,Nakashima K,Ushio R,Ikeda M,Narita A,Kanai A,Sato T,Kaneko T

更新日期：2016-12-13 00:00:00

abstract：:Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized to be due to impairments in the early activation of subcortical orienting mechanisms, which in typical development bias newborns to orient to relevant social visual stimuli. A challenge to testing this hypothesis is that autism is us...

journal_title：Scientific reports

authors： Di Giorgio E,Frasnelli E,Rosa Salva O,Scattoni ML,Puopolo M,Tosoni D,NIDA-Network.,Simion F,Vallortigara G

更新日期：2016-05-20 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Koo B,Koh CS,Park HY,Lee HG,Chang JW,Choi S,Shin HC

更新日期：2017-12-19 00:00:00

abstract：:Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrPC into misfolded and aggregating PrPSc is the central event in prion disease, an alternative hypothesis suggests ...

journal_title：Scientific reports

authors： Czech A,Konarev PV,Goebel I,Svergun DI,Wills PR,Ignatova Z

更新日期：2019-02-21 00:00:00

abstract：:Although various surgical procedures have been developed for chronic rotator cuff tear repair, the re-tear rate remains high with severe fat infiltration. However, little is known about the molecular regulation of this process. Mesenchymal stem cells (MSCs) in the intra-muscular space are origin of ectopic fat cells i...

journal_title：Scientific reports

authors： Lee D,Taniguchi N,Sato K,Choijookhuu N,Hishikawa Y,Kataoka H,Morinaga H,Lotz M,Chosa E

更新日期：2018-06-25 00:00:00

abstract：:In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...

journal_title：Scientific reports

authors： Lu Y,Chen S,Wu W,Du Z,Chao Y,Cui J

更新日期：2017-01-06 00:00:00

abstract：:The discovery of the community structure of real-world networks is still an open problem. Many methods have been proposed to shed light on this problem, and most of these have focused on discovering node community. However, link community is also a powerful framework for discovering overlapping communities. Here we pr...

journal_title：Scientific reports

authors： Liu W,Jiang X,Pellegrini M,Wang X

更新日期：2016-03-01 00:00:00

abstract：:The reliable identification of diffuse large B-cell lymphoma (DLBCL)-specific targets owns huge implications for its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are implicated in DLBCL pathogenesis; however, circulating DLBCL-related lncRNAs are barely investigated. We investigated plasma lncRNAs; HOTAIR, ...

journal_title：Scientific reports

authors： Senousy MA,El-Abd AM,Abdel-Malek RR,Rizk SM

更新日期：2021-01-22 00:00:00

abstract：:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...

journal_title：Scientific reports

authors： Shen ML,Wang CH,Lin CH,Zhou N,Kao ST,Wu DC

更新日期：2016-09-06 00:00:00

abstract：:Spin torque oscillator (STO) has been attracting a great deal of attention as a candidate for the next generation microwave signal sources for various modern electronics systems since its advent. However, the phase noise of STOs under free running oscillation is still too large to be used in practical microwave applic...

journal_title：Scientific reports

authors： Tamaru S,Kubota H,Yakushiji K,Yuasa S,Fukushima A

更新日期：2015-12-11 00:00:00

abstract：:Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the diversity of molecular changes that occur in these tissues may guide the development of ...

journal_title：Scientific reports

authors： Hamilton PJ,Chen EY,Tolstikov V,Peña CJ,Picone JA,Shah P,Panagopoulos K,Strat AN,Walker DM,Lorsch ZS,Robinson HL,Mervosh NL,Kiraly DD,Sarangarajan R,Narain NR,Kiebish MA,Nestler EJ

更新日期：2020-10-22 00:00:00

abstract：:Electrophysiological field potential dynamics have been widely used to investigate brain functions and related psychiatric disorders. Considering recent demand for its applicability to freely moving subjects, especially for animals in a group and socially interacting with each other, here we propose a new method based...

journal_title：Scientific reports

authors： Inagaki S,Agetsuma M,Ohara S,Iijima T,Yokota H,Wazawa T,Arai Y,Nagai T

更新日期：2019-05-16 00:00:00

abstract：:The Fabry-Pérot interferometer is used in a variety of high-precision optical interferometry applications, such as gravitational wave detection. It is also used in various types of laser resonators to act as a narrow band filter. In addition, ultra-compact Fabry-Pérot interferometers are used in the optical resonators...

journal_title：Scientific reports

authors： Tsujiie Y,Kawamura Y

更新日期：2018-10-12 00:00:00

abstract：:Compact and power-efficient plastic electronic synapses are of fundamental importance to overcoming the bottlenecks of developing a neuromorphic chip. Memristor is a strong contender among the various electronic synapses in existence today. However, the speeds of synaptic events are relatively slow in most attempts at...

journal_title：Scientific reports

authors： Li Y,Zhong Y,Xu L,Zhang J,Xu X,Sun H,Miao X

更新日期：2013-01-01 00:00:00