Abstract：
:Impaired wound healing is an immense medical challenge, and while autologous skin grafting remains the "gold-standard" therapeutic option for repairing wounds that cannot be closed by primary or secondary intention, it is limited by substantial donor site morbidity. We previously developed the alternative approach of harvesting full-thickness skin tissue in the form of "micro skin tissue columns" (MSTCs), without causing scarring or any other long-term morbidity. In this study we investigated how MSTC treatment affects the different cellular processes involved in wound healing. We found that MSTC-derived cells were able to remodel and repopulate the wound volume, and positively impact multiple aspects of the wound healing process, including accelerating re-epithelialization by providing multiple cell sources throughout the wound area, increasing collagen deposition, enhancing dermal remodeling, and attenuating the inflammatory response. These effects combined to enhance both epidermal and dermal wound healing. This MSTC treatment approach was designed for practical clinical use, could convey many benefits of autologous skin grafting, and avoids the major drawback of donor site morbidity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fuchs C,Pham L,Henderson J,Stalnaker KJ,Anderson RR,Tam Jdoi
10.1038/s41598-021-81179-7subject
Has Abstractpub_date
2021-01-18 00:00:00pages
1688issue
1issn
2045-2322pii
10.1038/s41598-021-81179-7journal_volume
11pub_type
杂志文章abstract：:Inhibitors of PD-1 signaling have revolutionized cancer therapy. PD-1 and PD-L1 antibodies have been approved for the treatment of cancer. To date, therapeutic PD-1 inhibitors have not been compared in a functional assay. We used an efficient T cell reporter platform to evaluate the efficacy of five clinically used PD...
journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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