Abstract：
:Mumps incidence in mainland China remains at a high level. Genotype F has been the predominant genotype of mumps virus (MuV) in the last 20 years in mainland China. To better understand the genetic characteristics of MuV in China, the sequences of the Small Hydrophobic (SH), Hemagglutinin-Neuraminidase (HN) and Fusion (F) genes of MuVs of genotype F collected during 2001-2015 were determined. The evolutionary rates of the HN and F genes were similar (0.5 × 10-3 substitutions/site/year) whereas the SH gene evolutionary rate was three times faster. The most recent common ancestor of genotype F was traced back to 1980. Four lineages were identified within HN and F MuV sequences. A phylogeographic analysis indicated that the genotype F viruses originally spread from the Liaoning and Shandong provinces followed by a spread to the South and East of China. This study provides important genetic baseline data for the development of prevention and control measures of mumps.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cui A,Rivailler P,Zhu Z,Deng X,Hu Y,Wang Y,Li F,Sun Z,He J,Si Y,Tian X,Zhou S,Lei Y,Zheng H,Rota PA,Xu Wdoi
10.1038/s41598-017-17474-zsubject
Has Abstractpub_date
2017-12-07 00:00:00pages
17144issue
1issn
2045-2322pii
10.1038/s41598-017-17474-zjournal_volume
7pub_type
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