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Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation.

Abstract：

:Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase ≥ 2 in the total NIHSS score or ≥ 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR) = 1.16, 95% confidence interval (CI) 1.00-1.34; P = 0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR = 1.03, 95% CI 1.00-1.06; P = 0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR = 0.35, 95% CI 0.23-0.54; P < 0.001) and new oral anticoagulants (aOR = 0.41, 95% CI 0.19-0.89; P = 0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Nam KW,Kim CK,Yu S,Chung JW,Bang OY,Kim GM,Jung JM,Song TJ,Kim YJ,Kim BJ,Heo SH,Park KY,Kim JM,Park JH,Choi JC,Park MS,Kim JT,Choi KH,Hwang YH,Seo WK,Oh K

doi

10.1038/s41598-020-69303-5

subject

Has Abstract

pub_date

2020-07-28 00:00:00

pages

12626

issue

1

issn

2045-2322

pii

10.1038/s41598-020-69303-5

journal_volume

10

pub_type

杂志文章

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