Abstract:
:In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy resistance. To promote nose-to-brain transport, we designed siRNA targeting Gal-1 (siGal-1) loaded chitosan nanoparticles that silence Gal-1 in the TME. Intranasal siGal-1 delivery induces a remarkable switch in the TME composition, with reduced myeloid suppressor cells and regulatory T cells, and increased CD4+ and CD8+ T cells. Gal-1 knock-down reduces macrophages' polarization switch from M1 (pro-inflammatory) to M2 (anti-inflammatory) during GBM progression. These changes are accompanied by normalization of the tumor vasculature and increased survival for tumor bearing mice. The combination of siGal-1 treatment with temozolomide or immunotherapy (dendritic cell vaccination and PD-1 blocking) displays synergistic effects, increasing the survival of tumor bearing mice. Moreover, we could confirm the role of Gal-1 on lymphocytes in GBM patients by matching the Gal-1 expression and their T cell signatures. These findings indicate that intranasal siGal-1 nanoparticle delivery could be a valuable adjuvant treatment to increase the efficiency of immune-checkpoint blockade and chemotherapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Van Woensel M,Mathivet T,Wauthoz N,Rosière R,Garg AD,Agostinis P,Mathieu V,Kiss R,Lefranc F,Boon L,Belmans J,Van Gool SW,Gerhardt H,Amighi K,De Vleeschouwer Sdoi
10.1038/s41598-017-01279-1subject
Has Abstractpub_date
2017-04-27 00:00:00pages
1217issue
1issn
2045-2322pii
10.1038/s41598-017-01279-1journal_volume
7pub_type
杂志文章abstract::CD26 displays variable levels between effector (TH17 ≫ TH1 > TH2 > Treg) and naïve/memory (memory > naïve) CD4+ T lymphocytes. Besides, IL-6/IL-6R is associated with TH17-differentiation and asthma severity. Allergic/atopic asthma (AA) is dominated by TH2 responses, while TH17 immunity might either modulate the TH2-de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43622-8
更新日期:2019-05-17 00:00:00
abstract::Enterobacter aerogenes LU2 was isolated from cow rumen and recognized as a potential succinic acid producer in our previous study. Here, we present the first complete genome sequence of this new, wild strain and report its basic genetic features from a biotechnological perspective. The MinION single-molecule nanopore ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58929-0
更新日期:2020-02-06 00:00:00
abstract::Due to the high CO2-footprint of ordinary Portland cement (OPC), the search for alternative binders is now in a full swing. Rankinite-which is a hydraulically inactive material and low in calcium, is a real alternative to OPC, as it absorbs the harmful greenhouse gas from the air through carbonation hardening. Neverth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71270-w
更新日期:2020-09-02 00:00:00
abstract::We demonstrate numerically and experimentally the enhancement of Surface Plasmon Resonance (SPR) sensing via dispersion engineering of the plasmonic response using plasmonic nanograting. Following their design and optimization, the plasmonic nanograting structures are fabricated using e-beam lithography and lift-off p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27023-x
更新日期:2018-06-13 00:00:00
abstract::While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail in approximately 25% of patients and these patients have limited treatment options. Another significant group of patients is being overtreated, which causes long-lasting side effects. Identification of molecules contro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15200-3
更新日期:2017-11-07 00:00:00
abstract::A highly sensitive microwave near-field sensor based on electrically-small planar resonators is proposed for highly accurate characterization of dielectric materials. The proposed sensor was developed in a robust complete-cycle topology optimization procedure wherein first the sensing area was pixelated. By maximizing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49767-w
更新日期:2019-09-16 00:00:00
abstract::One of the famous results of network science states that networks with heterogeneous connectivity are more susceptible to epidemic spreading than their more homogeneous counterparts. In particular, in networks of identical nodes it has been shown that network heterogeneity, i.e. a broad degree distribution, can lower ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13122
更新日期:2015-08-21 00:00:00
abstract::Auricle defects are important and common occurrences in forensic medicine. The accurate measurement and assessment of auricle defects is key to identifying and evaluating injury, and the currently available methods are known to be labor intensive and inaccurate. In this paper, we introduce an identification and docume...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21289-x
更新日期:2018-02-12 00:00:00
abstract::Cyanobacteria are attractive microbial hosts for production of chemicals using light and CO2. However, their low productivity of chemicals is a major challenge for commercial applications. This is mostly due to their relatively slow growth rate and carbon partitioning toward biomass rather than products. Many cyanobac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57319-5
更新日期:2020-01-15 00:00:00
abstract::Nowadays Field Emission Gun-Scanning Electron Microscopes provide detailed crystallographic information with high spatial and angular resolutions, and allow direct observation of crystalline defects, such as dislocations, through an attractive technique called Electron Channeling Contrast Imaging (ECCI). Dislocations ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09756-3
更新日期:2017-08-29 00:00:00
abstract::Bacterial vaginosis (BV) causes genital inflammation and increased HIV acquisition risk. The standard-of-care for BV, antibiotic therapy, is associated with high recurrence rates. Probiotics may improve treatment outcomes, although substantial heterogeneity in efficacy has been observed during clinical trials. To eval...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-38253-4
更新日期:2019-02-13 00:00:00
abstract::Two-dimensional nanostructures with controllable magnetic and electronic properties are desirable for their versatile applications in quantum devices. Here, we present a first-principles design on their magnetic and electronic switching controlled by tension. We find that hydrogenated VTe2 monolayer experiences a tran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07524
更新日期:2014-12-17 00:00:00
abstract::Cassava is one of the most important root crops as a reliable source of food and carbohydrates. Carbohydrate metabolism and starch accumulation in cassava storage root is a cascade process that includes large amounts of proteins and cofactors. Here, comparative proteomics were conducted in cassava root at nine develop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19643
更新日期:2016-01-21 00:00:00
abstract::Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three differ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70894-2
更新日期:2020-08-18 00:00:00
abstract::Temporal binding of urea to lysozyme was examined using X-ray diffraction of single crystals of urea/lysozyme complexes prepared by soaking native lysozyme crystals in solutions containing 9 M urea. Four different soak times of 2, 4, 7 and 10 hours were used. The five crystal structures (including the native lysozyme)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32277
更新日期:2016-08-30 00:00:00
abstract::The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between the -10 promoter element and the transcription start site of the regu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27780-9
更新日期:2018-06-21 00:00:00
abstract::Graphene quantum dots (GQDs) have received much attention due to their novel phenomena of charge transport and light absorption/emission. The optical transitions are known to be available up to ~6 eV in GQDs, especially useful for ultraviolet (UV) photodetectors (PDs). Thus, the demonstration of photodetection gain wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05603
更新日期:2014-07-07 00:00:00
abstract::Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-69560-4
更新日期:2020-07-31 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-28390-1
更新日期:2018-07-03 00:00:00
abstract::Psychopathic traits of conduct disorder (CD) have a core callous-unemotional (CU) component and an impulsive-antisocial component. Previous task-driven fMRI studies have suggested that psychopathic traits are associated with dysfunction of several brain areas involved in different cognitive functions (e.g., empathy, r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11775-z
更新日期:2017-09-12 00:00:00
abstract::We discuss a scheme to retrieve transient conformational molecular structure information using photoelectron angular distributions (PADs) that have averaged over partial alignments of isolated molecules. The photoelectron is pulled out from a localized inner-shell molecular orbital by an X-ray photon. We show that a t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23655
更新日期:2016-03-30 00:00:00
abstract::Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of ske...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61059-2
更新日期:2020-03-04 00:00:00
abstract::Influenza A viruses can infect a wide variety of animal species and, occasionally, humans. Infection occurs through the binding formed by viral surface glycoprotein hemagglutinin and certain types of glycan receptors on host cell membranes. Studies have shown that the α2,3-linked sialic acid motif (SA2,3Gal) in avian,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15778
更新日期:2015-10-28 00:00:00
abstract::Viral nervous necrosis (VNN) certainly represents the biggest challenge for the sustainability and the development of aquaculture. A large number of economically relevant fish species have proven to be susceptible to the disease. Conversely, gilthead sea bream has generally been considered resistant to VNN, although i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46755
更新日期:2017-05-02 00:00:00
abstract::Although the power conversion efficiency (PCE) of perovskite solar cells (PSCs) reached up to 23%, their short lifetime and fast degradation still remain as the main challenges. In this work, a new facile optical method based on the high power UV-irradiation is presented for the recovery of the degraded PSCs. Addition...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45756-1
更新日期:2019-07-01 00:00:00
abstract::The detection and assessment of intravascular filling defects is important, because they may represent a process central to cerebral malaria pathogenesis: neurovascular sequestration. We have developed and validated a framework that can automatically detect intravascular filling defects in fluorescein angiogram images...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11154
更新日期:2015-06-08 00:00:00
abstract::Traumatic brain injury (TBI) is a risk factor for Alzheimer's disease (AD), although the mechanisms contributing to this increased risk are unknown. Insulin resistance is an additional risk factor for AD whereby decreased insulin signaling increases synaptic sensitivity to amyloid beta (Aβ) and tau. Considering this, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44635-z
更新日期:2019-06-03 00:00:00
abstract::This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predictive model was developed in a primary prospective cohort consisting of 208 patients with niche treated by hyste...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74622-8
更新日期:2020-10-15 00:00:00
abstract::The ability of human metaphase-II arrested eggs to activate following fertilisation declines with advancing maternal age. Egg activation is triggered by repetitive increases in intracellular Ca(2+) concentration ([Ca(2+)]i) in the ooplasm as a result of sperm-egg fusion. We therefore hypothesised that eggs from older ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19357
更新日期:2016-01-20 00:00:00
abstract::The brain effortlessly recognizes objects even when the visual information belonging to an object is widely separated, as well demonstrated by the Kanizsa-type illusory contours (ICs), in which a contour is perceived despite the fragments of the contour being separated by gaps. Such large-range visual completion has l...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep08346
更新日期:2015-02-10 00:00:00