2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation.

abstract：:Venom gland is a highly efficient venom production system to maintain their predatory arsenal. Venom toxins mRNA has been shown to increase abruptly in snake after venom expenditure, while the dynamics of venom accumulation during synthesis are poorly understood. Here, PacBio long-read sequencing, Illumina RNA sequenc...

journal_title：Scientific reports

authors： Yin X,Guo S,Gao J,Luo L,Liao X,Li M,Su H,Huang Z,Xu J,Pei J,Chen S

更新日期：2020-08-24 00:00:00

abstract：:In some fibroblasts, casein kinase 1α (CK1α) is localized to nuclear speckles, which are sub-nuclear compartments supplying splicing factors, whereas it is recruited on keratin filaments in colorectal cancer cells such as DLD1 cells. In order to obtain a deeper understanding of why CK1α is localized to these different...

journal_title：Scientific reports

authors： Kuga T,Kume H,Adachi J,Kawasaki N,Shimizu M,Hoshino I,Matsubara H,Saito Y,Nakayama Y,Tomonaga T

更新日期：2016-09-29 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) patients have poor prognosis and poor response to treatment. This is largely due to PDAC being associated with a dense and active stroma and tumor fibrosis (desmoplasia). Desmoplasia is characterized by excessive degradation and formation of the extracellular matrix (ECM) genera...

journal_title：Scientific reports

authors： Willumsen N,Ali SM,Leitzel K,Drabick JJ,Yee N,Polimera HV,Nagabhairu V,Krecko L,Ali A,Maddukuri A,Moku P,Ali A,Poulose J,Menon H,Pancholy N,Costa L,Karsdal MA,Lipton A

更新日期：2019-12-24 00:00:00

abstract：:Floral transition and petal onset, as two main aspects of flower development, are crucial to rapeseed evolutionary success and yield formation. Currently, very little is known regarding the genetic architecture that regulates flowering time and petal morphogenesis in Brassica napus. In the present study, a genome-wide...

journal_title：Scientific reports

authors： Yu K,Wang X,Chen F,Chen S,Peng Q,Li H,Zhang W,Hu M,Chu P,Zhang J,Guan R

更新日期：2016-07-27 00:00:00

abstract：:Since the production of ferromagnetic graphene as an extremely important matter in spintronics has made a revolution in future technology, a great deal of efforts has recently been done to reach a simple and cost-effective method. Up to now, controlling the magnetic properties at extremely low temperature have been in...

journal_title：Scientific reports

authors： Alimohammadian M,Sohrabi B

更新日期：2020-12-07 00:00:00

abstract：:Evolutions of Asian and Australian monsoons have important significance for understanding the past global change but are still a controversial subject. Here, we explore systematically the effects of plate movement and plateau uplift on the formation and evolution of the Asian and Australian monsoons by numerical simul...

journal_title：Scientific reports

authors： Liu X,Dong B,Yin ZY,Smith RS,Guo Q

更新日期：2017-01-13 00:00:00

abstract：:Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinka...

journal_title：Scientific reports

authors： Wang C,Tang D,Wang Y,Zhao Z,Wang J,Pu M,Zhang Y,Yan W,Gao P,Luo X

更新日期：2015-12-18 00:00:00

abstract：:The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegy...

journal_title：Scientific reports

authors： Tang L,Li K,Zhang Y,Li H,Li A,Xu Y,Wei B

更新日期：2020-02-12 00:00:00

abstract：:In this paper, we propose a feasible tool that uses a terahertz (THz) imaging system for identifying wheat grains at different stages of germination. The THz spectra of the main changed components of wheat grains, maltose and starch, which were obtained by THz time spectroscopy, were distinctly different. Used for ori...

journal_title：Scientific reports

authors： Jiang Y,Ge H,Lian F,Zhang Y,Xia S

更新日期：2016-02-19 00:00:00

abstract：:The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation and represent an a...

journal_title：Scientific reports

authors： Espana-Agusti J,Tuveson DA,Adams DJ,Matakidou A

更新日期：2015-06-05 00:00:00

abstract：:Scientific Reports 7: Article number: 45816; published online: 06 April 2017; updated: 16 May 2017. The original version of this Article contained an error in Affiliation 2, which was incorrectly given as: 'Department of Biophysics, School of Life Sciences, Manipal University, Manipal, 567014, India'. ...

journal_title：Scientific reports

authors： Mazumder N,Xiang LY,Qiu J,Kao FJ

更新日期：2017-05-16 00:00:00

abstract：:While the Wnt/β-catenin pathway plays a critical role in the maintenance of the zonation of ammonia metabolizing enzymes in the adult liver, the mechanisms responsible for inducing zonation in the embryo are not well understood. Herein we address the spatiotemporal role of the Wnt/β-catenin pathway in the development ...

journal_title：Scientific reports

authors： Burke ZD,Reed KR,Yeh SW,Meniel V,Sansom OJ,Clarke AR,Tosh D

更新日期：2018-02-09 00:00:00

abstract：:The investigation of chemical and structural dynamics in battery materials is essential to elucidation of structure-property relationships for rational design of advanced battery materials. Spatially resolved techniques, such as scanning/transmission electron microscopy (S/TEM), are widely applied to address this chal...

journal_title：Scientific reports

authors： Lin F,Markus IM,Doeff MM,Xin HL

更新日期：2014-07-16 00:00:00

abstract：:The controlled interaction of two high intensity beams opens new degrees of freedom for manipulating electromagnetic waves in air. The growing number of applications for laser filaments requires fine control of their formation and propagation. We demonstrate, experimentally and theoretically, that the attraction and f...

journal_title：Scientific reports

authors： Rostami Fairchild S,Walasik W,Kepler D,Baudelet M,Litchinitser NM,Richardson M

更新日期：2017-08-31 00:00:00

abstract：:Rs1042522 (Arg72Pro) is a functional polymorphism of TP53. Pro72 has been associated with lower all-cause mortality and lower mortality after cancer. We hypothesized that TP53 Pro72 is associated with lower mortality after cancer, lower all-cause mortality, and with increased cancer incidence in the general population...

journal_title：Scientific reports

authors： Kodal JB,Vedel-Krogh S,Kobylecki CJ,Nordestgaard BG,Bojesen SE

更新日期：2017-03-23 00:00:00

abstract：:Amyloid precursor protein (APP) intracellular domain (AICD) is a product of APP processing with transcriptional modulation activity, whose overexpression causes various Alzheimer's disease (AD)-related dysfunctions. Here we report that 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid) (CHF50...

journal_title：Scientific reports

authors： Branca C,Sarnico I,Ruotolo R,Lanzillotta A,Viscomi AR,Benarese M,Porrini V,Lorenzini L,Calzà L,Imbimbo BP,Ottonello S,Pizzi M

更新日期：2014-04-09 00:00:00

abstract：:Hydraulic extended-reach limit (HERL) model of horizontal extended-reach well (ERW) can predict the maximum measured depth (MMD) of the horizontal ERW. The HERL refers to the well's MMD when drilling fluid cannot be normally circulated by drilling pump. Previous model analyzed the following two constraint conditions, ...

journal_title：Scientific reports

authors： Li X,Gao D,Chen X

更新日期：2017-06-08 00:00:00

abstract：:Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD). Therefore, we have formulated the first western-style diet that mimics the fat, carbohydrate, protein, vitamin and mineral levels of wester...

journal_title：Scientific reports

authors： Graham LC,Harder JM,Soto I,de Vries WN,John SW,Howell GR

更新日期：2016-02-18 00:00:00

abstract：:Avoiding immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) transplantation is a concern. However, mesenchymal stem cells (MSCs) can suppress immune rejection. To determine whether MSC co-transplantation can reduce immune rejection after allogeneic iPSC-CM transplantation, ...

journal_title：Scientific reports

authors： Yoshida S,Miyagawa S,Toyofuku T,Fukushima S,Kawamura T,Kawamura A,Kashiyama N,Nakamura Y,Toda K,Sawa Y

更新日期：2020-03-12 00:00:00

abstract：:Peak heat flow occurs at mid-ocean ridges and decreases with the age of the oceanic lithosphere. Several plate models, including the Parsons and Sclater (PSM) model, Global Depth and Heat (GDH1) model and Constant Heat flow Applied on the Bottom Lithospheric Isotherm (CHABLIS) model, have been used to predict heat flo...

journal_title：Scientific reports

authors： Qiuming C

更新日期：2016-01-13 00:00:00

abstract：:Macrophages play a crucial role in the control and elimination of invading Mycobacterium tuberculosis (Mtb), and also serve as the major residence for Mtb. However, the interaction between macrophages and Mtb remains to be clearly determined. Although long noncoding RNAs (lncRNAs) have emerged as key regulators in man...

journal_title：Scientific reports

authors： Yang X,Yang J,Wang J,Wen Q,Wang H,He J,Hu S,He W,Du X,Liu S,Ma L

更新日期：2016-12-14 00:00:00

abstract：:Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors. One major obstacle is the blood-brain barrier (BBB), which hinders efficient passage of tumor biomarkers into the peripheral circulation. The ob...

journal_title：Scientific reports

authors： Zhu L,Cheng G,Ye D,Nazeri A,Yue Y,Liu W,Wang X,Dunn GP,Petti AA,Leuthardt EC,Chen H

更新日期：2018-04-26 00:00:00

abstract：:DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amendments (CLIA) compliant setting enables a single assay to provide: therapeutic ...

journal_title：Scientific reports

authors： Borad MJ,Egan JB,Condjella RM,Liang WS,Fonseca R,Ritacca NR,McCullough AE,Barrett MT,Hunt KS,Champion MD,Patel MD,Young SW,Silva AC,Ho TH,Halfdanarson TR,McWilliams RR,Lazaridis KN,Ramanathan RK,Baker A,Aldrich J,

更新日期：2016-12-23 00:00:00

abstract：:Emergence of new molecules acting directly on the hepatitic C virus (HCV) has improved treatment outcomes. However, there is a risk of selecting viral escape mutants, so a new combination is needed using different inhibitors that target different steps of the HCV infectious cycle. Novel single tablet formulations were...

journal_title：Scientific reports

authors： Shiha G,Soliman R,Elbasiony M,Darwish NHE,Mousa SA

更新日期：2019-09-19 00:00:00

abstract：:We propose a model of a learning agent whose interaction with the environment is governed by a simulation-based projection, which allows the agent to project itself into future situations before it takes real action. Projective simulation is based on a random walk through a network of clips, which are elementary patch...

journal_title：Scientific reports

authors： Briegel HJ,De las Cuevas G

更新日期：2012-01-01 00:00:00

abstract：:The numerous species that make up the oral microbiome are now understood to play a key role in establishment and maintenance of oral health. The ability to taxonomically identify community members at the species level is important to elucidating its diversity and association to health and disease. We report the overal...

journal_title：Scientific reports

authors： Adams SE,Arnold D,Murphy B,Carroll P,Green AK,Smith AM,Marsh PD,Chen T,Marriott RE,Brading MG

更新日期：2017-02-27 00:00:00

abstract：:Elastic waves are guided along finite structures such as cylinders, plates, or rods through reflection, refraction, and mode conversion at the interfaces. Such wave propagation is ubiquitous in the world around us, and studies of elastic waveguides first emerged in the later part of the 19(th) century. Early work on e...

journal_title：Scientific reports

authors： Philippe FD,Murray TW,Prada C

更新日期：2015-06-08 00:00:00

abstract：:The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. It consists of the catalytic subunits IKKα and IKKβ and the regulatory subunit NEMO/IKKγ. Here, we show that the ubiquitin binding domain (UBAN) in NEMO is essential for IKK/NF-κB act...

journal_title：Scientific reports

authors： Vincendeau M,Hadian K,Messias AC,Brenke JK,Halander J,Griesbach R,Greczmiel U,Bertossi A,Stehle R,Nagel D,Demski K,Velvarska H,Niessing D,Geerlof A,Sattler M,Krappmann D

更新日期：2016-01-07 00:00:00

abstract：:The extraction and encoding of acoustical temporal regularities are fundamental for human cognitive auditory abilities such as speech or beat entrainment. Because the comparison of the neural sensitivity to temporal regularities between human and animals is fundamental to relate non-invasive measures of auditory proce...

journal_title：Scientific reports

authors： Ayala YA,Lehmann A,Merchant H

更新日期：2017-11-30 00:00:00

abstract：:Plant health is strongly connected with plants´ microbiome. In case of raw-eaten plants, the microbiome can also affect human health. To study potential impacts on health issues of both hosts, the microbiome composition of seven different Brassica vegetables, originating from different food processing pathways, was an...

journal_title：Scientific reports

authors： Wassermann B,Rybakova D,Müller C,Berg G

更新日期：2017-12-15 00:00:00