Abstract:
:Because Africa's climate hampers DNA preservation, knowledge of its genetic variability is mainly restricted to modern samples, even though population genetics dynamics and back-migrations from Eurasia may have modified haplotype frequencies, masking ancient genetic scenarios. Thanks to improved methodologies, ancient genetic data for the African continent are now increasingly available, starting to fill in the gap. Here we present newly obtained mitochondrial genomes from two ~7000-year-old individuals from Takarkori rockshelter, Libya, representing the earliest and first genetic data for the Sahara region. These individuals carry a novel mutation motif linked to the haplogroup N root. Our result demonstrates the presence of an ancestral lineage of the N haplogroup in the Holocene "Green Sahara", associated to a Middle Pastoral (Neolithic) context.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vai S,Sarno S,Lari M,Luiselli D,Manzi G,Gallinaro M,Mataich S,Hübner A,Modi A,Pilli E,Tafuri MA,Caramelli D,di Lernia Sdoi
10.1038/s41598-019-39802-1subject
Has Abstractpub_date
2019-03-05 00:00:00pages
3530issue
1issn
2045-2322pii
10.1038/s41598-019-39802-1journal_volume
9pub_type
杂志文章abstract::Age of complementary foods introduction is associated with childhood anemia, but the ideal age for the introduction of complementary foods to infants is a continuing topic of debate. We examined the longitudinal association between complementary foods introduction age and risk of anemia in 18,446 children from the Jia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44726
更新日期:2017-03-23 00:00:00
abstract::Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35966
更新日期:2016-10-25 00:00:00
abstract::Phytoene desaturases catalyse from two to six desaturation reactions on phytoene, generating a large diversity of molecules that can then be cyclised and produce, depending on the organism, many different carotenoids. We constructed a phylogenetic tree of a subset of phytoene desaturases from the CrtI family for which...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77876-4
更新日期:2020-12-03 00:00:00
abstract::Aquaculture is a burgeoning industry, requiring diversification into new farmed species, which are often at risk from infectious disease. We used a mesocosm technique to investigate the susceptibility of sharpsnout seabream (Diplodus puntazzo) larvae to potential environmental pathogens in seawater compared to control...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17609
更新日期:2015-12-07 00:00:00
abstract::We aimed to investigate the changes of olfaction of major depressive disorder (MDD) before and after medical treatment, and to preliminarily scrutinize the association between the olfactory function and the severity of depressive symptoms, response inhibition, and emotional responding. Forty-eight medicine-naïve MDD p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63416-7
更新日期:2020-04-14 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-67920-8
更新日期:2020-06-26 00:00:00
abstract::In this article a new spent catalyst sample preparation method was implemented for the purpose of molybdenum leaching in a single step. Further molybdenum and vanadium in the leach liquor were separated and their concentrations were enriched using the solvent extraction and stripping techniques. The impervious sulfur ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58972-x
更新日期:2020-02-06 00:00:00
abstract::A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue engineering research have limited access to control the geometry. Furthermore, 3D cell culture plate manufacturing methods are r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50186-0
更新日期:2019-09-27 00:00:00
abstract::Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34894
更新日期:2016-10-07 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-21513-8
更新日期:2018-02-19 00:00:00
abstract::Intermediate level radioactive waste (ILW) generally contains a heterogeneous range of organic and inorganic materials, of which some are encapsulated in cement. Of particular concern are cellulosic waste items, which will chemically degrade under the conditions predicted during waste disposal, forming significant qua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26963-8
更新日期:2018-06-08 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33535
更新日期:2016-09-15 00:00:00
abstract::Changes in N-glycosylation of plasma proteins are observed in many types of cancer, nevertheless, few studies suggest the exact mechanism involved in aberrant protein glycosylation. Here we studied the impact of DNA methylation on the N-glycome in the secretome of the HepG2 cell line derived from hepatocellular carcin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24363
更新日期:2016-04-13 00:00:00
abstract::We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81501-3
更新日期:2021-01-21 00:00:00
abstract::Hatching out from the zona pellucida (ZP) is a crucial step for blastocyst implantation and development. However, it is still unknown whether the location of the hatching site relative to the inner cell mass (ICM) affects embryo implantation and foetal development. Here, we classified hatching blastocysts into three c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59424-2
更新日期:2020-02-12 00:00:00
abstract::The distribution of attention between competing processing demands can have dramatic real-world consequences, however little is known about how limited attentional resources are distributed during real-world behaviour. Here we employ mobile EEG to characterise the allocation of attention across multiple sensory-cognit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51996-y
更新日期:2019-11-01 00:00:00
abstract::Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01521-w
更新日期:2017-05-02 00:00:00
abstract::Valproic acid (VPA) is a drug commonly used for epileptic seizure control. Recently, it has been shown that VPA alters the activation of several immune cells, including Natural Killer (NK) cells, which play an important role in the containment of viruses and intracellular bacteria. Although VPA can increase susceptibi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74836-w
更新日期:2020-10-20 00:00:00
abstract::In this paper, the annually average Defense Meteorological Satellite Program-Operational Linescan System (DMSP/OLS) night-time light data is first proposed as a surrogate indicator to mine and forecast the average housing prices in the inland capital cities of China. First, based on the time-series analysis of individ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64506-2
更新日期:2020-05-07 00:00:00
abstract::With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes in its history. The 668,500-hectare Greater Mara is of crucial importance for the great migrations of large mammals and for Maasai pastoralis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41450
更新日期:2017-01-25 00:00:00
abstract::A novel and simple method to fabricate microchannels is reported based on an inkjet printing of a volatile solid mold. A liquid ink -1,6 hexanediol- ejected from a piezoelectric nozzle is instantaneously frozen when touching a cooled substrate. The created mold is then poured with PDMS. Once the PDMS is crosslinked, t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53729-7
更新日期:2019-11-25 00:00:00
abstract::Donor-specific CD4+CD127-CD25+FOXP3+ regulatory T cells (AgTregs) have the potential to induce clinical transplant tolerance; however, their expansion ex vivo remains challenging. We optimized a novel expansion protocol to stimulate donor-specific Tregs using soluble 4-trimer CD40 ligand (CD40L)-activated donor B cell...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19621-6
更新日期:2018-01-18 00:00:00
abstract::This study evaluates the association between indoor microbial diversity early in life and hyperactivity/inattention symptoms in children at ages 10 and 15 years.A random sample enriched with subjects with hyperactivity/inattention at age 15 years was selected from the German LISA birth cohort. Bedroom floor dust was c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53527-1
更新日期:2019-11-22 00:00:00
abstract::Brazil's large land base is important for global food security but its high dependency on inorganic phosphorus (P) fertilizer for crop production (2.2 Tg rising up to 4.6 Tg in 2050) is not a sustainable use of a critical and price-volatile resource. A new strategic analysis of current and future P demand/supply concl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20887-z
更新日期:2018-02-07 00:00:00
abstract::Increasing levels of human activity threaten wildlife populations through direct mortality, habitat degradation, and habitat fragmentation. Area closures can improve habitat quality for wildlife, but may be difficult to achieve where tourism or other economic drivers are a priority. Temporal closures that limit human ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40581-y
更新日期:2019-03-07 00:00:00
abstract::Graphene, a honeycomb lattice of carbon atoms ruled by tight-binding interaction, exhibits extraordinary electronic properties due to the presence of Dirac cones within its band structure. These intriguing singularities have naturally motivated the discovery of their classical analogues. In this work, we present a gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15335-3
更新日期:2017-11-10 00:00:00
abstract::Antibiotic resistance, a consequence of antibiotic use, is a threat to health, with severe consequences for resource constrained settings. If determinants for human antibiotic use in India, a lower middle income country, with one of the highest antibiotic consumption in the world could be understood, interventions cou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24883-1
更新日期:2018-04-23 00:00:00
abstract::Conifer wood is an exceptionally stiff and strong material when its cellulose microfibrils are well aligned. However, it is not well understood how the polymer components cellulose, hemicelluloses and lignin co-operate to resist tensile stress in wood. From X-ray scattering, neutron scattering and spectroscopic data, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79676-2
更新日期:2021-01-11 00:00:00
abstract::On an SiO2-patterned c-plane sapphire substrate, GaN domains were grown with their polarity controlled in accordance with the pattern. While N-polar GaN was grown on hexagonally arranged circular openings, Ga-polar GaN was laterally overgrown on mask regions due to polarity inversion occurring at the boundary of the c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22424-4
更新日期:2018-03-07 00:00:00
abstract::The plasmodial CTP:phosphocholine cytidylyltransferase (PfCCT) is a promising antimalarial target, which can be inhibited to exploit the need for increased lipid biosynthesis during the erythrocytic life stage of Plasmodium falciparum. Notable structural and regulatory differences of plasmodial and mammalian CCTs offe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27183-w
更新日期:2018-06-12 00:00:00