Abstract:
:Cardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity. Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiac profile could reflect differences in cardiac function and structure in obese and non-obese rats with myocardial infarction (MI). Whether these changes can also be reflected in a specific plasma miRNA signature as markers of cardiac damage was also evaluated. Rats were fed with either standard (3.5% fat) or high fat diet (35% fat) for 6 weeks before the induction of MI and sacrificed 4 weeks later. MI showed cardiac lipotoxicity independently of the presence of obesity, although obese and non-obese rats did not present the same cardiac lipid profile at mitochondrial level. Several cardiac lipid species in mitochondria, including cardiolipins and triglycerides, were associated with myocardial fibrosis, with mitochondrial triglyceride levels being independently associated with it; this supports that lipotoxicity can affect cardiac function. MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. This could support that lipotoxicity could affect heart function by modulating plasma miRNAs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Marín-Royo G,Ortega-Hernández A,Martínez-Martínez E,Jurado-López R,Luaces M,Islas F,Gómez-Garre D,Delgado-Valero B,Lagunas E,Ramchandani B,García-Bouza M,Nieto ML,Cachofeiro Vdoi
10.1038/s41598-018-36914-ysubject
Has Abstractpub_date
2019-01-24 00:00:00pages
444issue
1issn
2045-2322pii
10.1038/s41598-018-36914-yjournal_volume
9pub_type
杂志文章abstract::Cartilage loss is a leading cause of disability among adults and effective therapy remains elusive. Neonatal chondrocytes (NChons) are an attractive allogeneic cell source for cartilage repair, but their clinical translation has been hindered by scarce donor availability. Here we examine the potential for catalyzing c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03553
更新日期:2013-12-19 00:00:00
abstract::To compare the soil water balance, yield and water use efficiency (WUE) of spring maize under different mulching types in the Loess Plateau, a 7-year field experiment was conducted in the Changwu region of the Loess Plateau. Three treatments were used in this experiment: straw mulch (SM), plastic film mulch (PM) and c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38995
更新日期:2016-12-15 00:00:00
abstract::We introduce a method to study the spatial profiles of standing spin waves in ferromagnetic microstructures. The method relies on Nuclear Resonant Scattering of 57Fe using a microfocused beam of synchrotron radiation, the transverse coherence length of which is smaller than the length scale of lateral variations in th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29596-z
更新日期:2018-07-26 00:00:00
abstract::High frequency oscillations (HFOs) are bursts of neural activity in the range of 80 Hz or higher, recorded from intracranial electrodes during epileptiform discharges. HFOs are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting. Despite such clinical utility of HFOs, the spat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76138-7
更新日期:2020-11-05 00:00:00
abstract::Silver nanorod arrays prepared by oblique angle deposition (AgOADs) represent versatile, simple and inexpensive substrates for high sensitivity surface enhanced Raman scattering (SERS) applications. Their anisotropic nature suggests that their optical responses such as the SERS signal, the depolarization ratio, reflec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04565-0
更新日期:2017-06-27 00:00:00
abstract::This study aimed to determine whether bisphosphonates exert an effect on preventing femoral head collapse after osteonecrosis of the femoral head (ONFH) in an animal model and in clinical trials. A systematic literature search was performed for studies published up to January 2017. Twenty-three articles (16 animal stu...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-19884-z
更新日期:2018-01-23 00:00:00
abstract::Data on predictors of intraoperative cardiac arrest (ICA) outcomes are scarce in the literature. This study analysed predictors of poor outcome and their prognostic value after an ICA. Clinical and laboratory data before and 24 hours (h) after ICA were analysed as predictors for no return of spontaneous circulation (R...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51557-3
更新日期:2019-10-18 00:00:00
abstract::Horizontal gene transfer (HGT) drives the evolution of recipient organism particularly if it provides a novel function which enhances the fitness or its adaption to the environment. Virus-host co-evolution is attractive for studying co-evolutionary processes, since viruses strictly replicate inside of the host cells a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26934
更新日期:2016-06-07 00:00:00
abstract::Estimating the potential distribution of invasive species has been primarily achieved by employing species distribution models (SDM). Recently introduced joint species distribution models (JSDM) that include species interactions are expected to improve model output. Here we compare the predictive ability of SDM and JS...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52256-9
更新日期:2019-11-01 00:00:00
abstract::To evaluate the corneal spherical aberrations in cataract patients with and without high myopia, we conducted a retrospective case series of 502 cataract eyes with high myopia and 1500 age-related cataract eyes and measure their corneal biometric data and axial length using Pentacam and IOLMaster. Both the anterior an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36539-1
更新日期:2019-02-05 00:00:00
abstract::The electrowetting lenses has attracted researchers in many fields, such as biology, beam shaping, and drug delivery. Previous research on electrowetting lens has focused on neither expanding the dynamic focal length range nor reducing the wavefront aberration. However, the properties with large numerical aperture and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73260-4
更新日期:2020-10-01 00:00:00
abstract::The prevalence of type 2 diabetes (T2D) has increased dramatically in Middle Eastern populations that represent the largest non-European immigrant group in Sweden today. As proneurotensin predicts T2D, the aim of this study was to investigate differences in proneurotensin levels across populations of Middle Eastern an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50040-3
更新日期:2019-09-20 00:00:00
abstract::High efficiency polymer:fullerene photovoltaic device layers self-assemble with hierarchical features from ångströms to 100's of nanometers. The feature size, shape, composition, orientation, and order all contribute to device efficiency and are simultaneously difficult to study due to poor contrast between carbon bas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30915
更新日期:2016-08-08 00:00:00
abstract::Zinc oxy-selenide Zn(O,Se) is a novel material, that can replace the toxic CdS buffer layer in thin film solar cells and other optoelectronic devices. In this paper a systematic study of the structural, optical and electrical properties of Zn(O,Se) layers, grown by pulsed laser deposition under 50 mTorr of nitrogen ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54008-1
更新日期:2019-11-25 00:00:00
abstract::The Na(3p) + H2(X1Σg+) → NaH(X1Σ+) + H(2S) reaction plays an important role in the field of diabatic reaction dynamics. A set of new diabatic potential energy surfaces (PESs) of the NaH2 system are structured, which include the diabatic coupling between the lowest two adiabatic states. The electronic structure calcula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35987-z
更新日期:2018-12-19 00:00:00
abstract::Venom gland is a highly efficient venom production system to maintain their predatory arsenal. Venom toxins mRNA has been shown to increase abruptly in snake after venom expenditure, while the dynamics of venom accumulation during synthesis are poorly understood. Here, PacBio long-read sequencing, Illumina RNA sequenc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70565-2
更新日期:2020-08-24 00:00:00
abstract::Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-typ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61882-7
更新日期:2020-03-31 00:00:00
abstract::Large consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). Complementing these efforts, we genotyped previously reported SNPs in the human leukocyte antigen (HLA) class I (rs6457327) and class II (rs9271...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41400
更新日期:2017-01-31 00:00:00
abstract::Two yellow luminescence bands related to different defects have been revealed in undoped GaN grown by hydride vapor phase epitaxy (HVPE). One of them, labeled YL1, has the zero-phonon line (ZPL) at 2.57 eV and the band maximum at 2.20 eV at low temperature. This luminescence band is the ubiquitous yellow band observed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26354-z
更新日期:2018-05-25 00:00:00
abstract::Morphological phylogenies stand in a major conflict with molecular hypotheses regarding the phylogeny of Cryptodira, the most diverse and widely distributed clade of extant turtles. However, molecular hypotheses are often considered a better estimate of phylogeny given that it is more consistent with the stratigraphic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16299
更新日期:2015-11-10 00:00:00
abstract::Bacterial environmental and surgical site infection (SSI) surveillance was implemented from 2011-2016 in a UK Equine Referral Veterinary Hospital and identified 81 methicillin-resistant Staphylococcus aureus (MRSA) isolates. A cluster of MRSA SSIs occurred in early 2016 with the isolates confirmed as ST398 by multiloc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05559-8
更新日期:2017-07-14 00:00:00
abstract::This paper reports the application of anthracite particles of different sizes and coated with nine kinds of layered double hydroxides (LDHs) varying in M(II)-M(III) cations, as alternative substrates in the simulated vertical-flow constructed wetland columns. Effects of LDHs-coating and particle size of modified anthr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15146
更新日期:2015-10-12 00:00:00
abstract::Cake layer formation in membrane processes is an inevitable phenomenon. For hard particles, especially cake porosity and thickness determine the membrane flux, but when the particles forming the cake are soft, the variables one has to take into account in the prediction of cake behavior increase considerably. In this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39820-z
更新日期:2019-02-28 00:00:00
abstract::The trade of bumble bees started in the early nineties for pollinator-dependent greenhouse plants. Nowadays, its rearing and transport have received public attention, since managed bees can transfer pathogens to wild bee populations. Therefore, guaranteeing pathogen-free bumble bees is fundamental. The major protein s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40804-2
更新日期:2019-03-12 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the kinase domain of RT...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62460-7
更新日期:2020-03-25 00:00:00
abstract::The increasing demands in security and reliability of infrastructures call for the optimal design of their embedded complex networks topologies. The following question then arises: what is the optimal layout to fulfill best all the demands? Here we present a general solution for this problem with scale-free networks, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09082
更新日期:2015-03-13 00:00:00
abstract::Polymer electrolyte membranes (PEM) and Pt-based catalysts are two crucial components which determine the properties and price of fuel cells. Even though, PEM faces problem of fuel crossover in liquid fuel cells such as direct methanol fuel cell (DMFC) and direct borohydride fuel cell (DBFC), which lowers power output...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00567
更新日期:2012-01-01 00:00:00
abstract::As fine particle (FP) pollution is harmful to humans, previous studies have focused on the mechanisms of FP removal by forests. The current study aims to compare the FP removal capacities of urban forests and wetlands on the leaf, canopy, and landscape scales. Water washing and scanning electron microscopy are used to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46214
更新日期:2017-04-10 00:00:00
abstract::Electromyography (EMG) is the standard technology for monitoring muscle activity in laboratory environments, either using surface electrodes or fine wire electrodes inserted into the muscle. Due to limitations such as cost, complexity, and technical factors, including skin impedance with surface EMG and the invasive n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41860-4
更新日期:2019-04-03 00:00:00
abstract::Owing to the diversity of pulse-wave morphology, pulse-based diagnosis is difficult, especially pulse-wave-pattern classification (PWPC). A powerful method for PWPC is a convolutional neural network (CNN). It outperforms conventional methods in pattern classification due to extracting informative abstraction and featu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51334-2
更新日期:2019-10-17 00:00:00