Abstract：
:The present study aimed to determine the effect of thyroid hormone dysfunction on brown adipose tissue activity and white adipose tissue browning in mice. Twenty randomized female C57BL/6NTac mice per treatment group housed at room temperature were rendered hypothyroid or hyperthyroid. In-vivo small animal 18F-FDG PET/MRI was performed to determine the effects of hypo- and hyperthyroidism on BAT mass and BAT activity. Ex-vivo14C-acetate loading assay and assessment of thermogenic gene and protein expression permitted analysis of oxidative and thermogenic capacities of WAT and BAT of eu-, hyper and hypothyroid mice. 18F-FDG PET/MRI revealed a lack of brown adipose tissue activity in hypothyroid mice, whereas hyperthyroid mice displayed increased BAT mass alongside enhanced 18F-FDG uptake. In white adipose tissue of both, hyper- and hypothyroid mice, we found a significant induction of thermogenic genes together with multilocular adipocytes expressing UCP1. Taken together, these results suggest that both the hyperthyroid and hypothyroid state stimulate WAT thermogenesis most likely as a consequence of enhanced adrenergic signaling or compensation for impaired BAT function, respectively.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Weiner J,Kranz M,Klöting N,Kunath A,Steinhoff K,Rijntjes E,Köhrle J,Zeisig V,Hankir M,Gebhardt C,Deuther-Conrad W,Heiker JT,Kralisch S,Stumvoll M,Blüher M,Sabri O,Hesse S,Brust P,Tönjes A,Krause Kdoi
10.1038/srep38124subject
Has Abstractpub_date
2016-12-12 00:00:00pages
38124issn
2045-2322pii
srep38124journal_volume
6pub_type
杂志文章abstract：:Usher Syndrome (USH) is a rare disease with hearing loss, retinitis pigmentosa and, sometimes, vestibular dysfunction. A phenotype heterogeneity is reported. Recent evidence indicates that USH is likely to belong to an emerging class of sensory ciliopathies. Olfaction has recently been implicated in ciliopathies, but ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep28309
更新日期：2016-06-22 00:00:00
abstract：:Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper understanding ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00477-1
更新日期：2017-03-27 00:00:00
abstract：:There is lack of consensus regarding the prognostic significance of primary tumor location of upper tract urothelial carcinoma(UTUC). We performed a meta-analysis to evaluate the impact of primary tumor location on prognosis in patients with UTUC who had undergone radical nephroureterectomy(RNU). We included eligible ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep06361
更新日期：2014-09-15 00:00:00
abstract：:Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80288-z
更新日期：2020-12-31 00:00:00
abstract：:Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03792
更新日期：2014-01-21 00:00:00
abstract：:Directional transport of auxin is essential for plant development, with PIN auxin transport proteins representing an integral part of the machinery that controls hormone distribution. However, unlike the rapidly emerging framework of molecular determinants regulating PIN protein abundance and subcellular localization,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32196
更新日期：2016-08-24 00:00:00
abstract：:The increasing availability of electronic health care records has provided remarkable progress in the field of population health. In particular the identification of disease risk factors has flourished under the surge of available data. Researchers can now access patient data across a broad range of demographics and g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30465
更新日期：2016-07-27 00:00:00
abstract：:At present, there is a growing interest in the study of the neurotropic activity of polyunsaturated fatty acids ethanolamides (N-acylethanolamines). N-docosahexaenoylethanolamine (DHEA, synaptamide) is an endogenous metabolite and structural analogue of anandamide, a widely studied endocannabinoid derived from arachid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80818-9
更新日期：2021-01-12 00:00:00
abstract：:Wheat (Triticum aestivum), one of the world's most important crops, is facing unprecedented challenges due to global warming. To evaluate the gene resources for heat adaptation in hexaploid wheat, small heat shock proteins (sHSPs), the key plant heat protection genes, were comprehensively analysed in wheat and related...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01857-3
更新日期：2017-05-31 00:00:00
abstract：:Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary purpose of this study was to determine the prognosis of AALA in critically ill patients and the second aim was to determine whether the survival was associated to the p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35368
更新日期：2016-10-17 00:00:00
abstract：:When acids are supplied with an excess electron (or placed in an Ar or the more polarizable N2 matrix) in the presence of species such as NH3, the formation of ion-pairs is a likely outcome. Using density functional theory and first-principles calculations, however, we show that, without supplying an external electron...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46725-4
更新日期：2019-07-23 00:00:00
abstract：:Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics. Here, we focus on the effects of long term use of antibiotic on gut microbiota and immunity. BALB/c mice rece...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43035
更新日期：2017-02-21 00:00:00
abstract：:Previous observational studies supported a positive association of glycated hemoglobin A1c (HbA1c) level with serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). However, the causal relationship between HbA1c and either one of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41076-6
更新日期：2019-04-02 00:00:00
abstract：:The melting of glaciers and ice sheets is nowadays considered a symbol of climate change. Many complex mechanisms are involved in the melting of ice, and, among these processes, surface darkening due to organic material on bare ice has recently received attention from the scientific community. The presence of microbes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61762-0
更新日期：2020-03-16 00:00:00
abstract：:Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02767-0
更新日期：2017-05-31 00:00:00
abstract：:The purpose of the present study was to assess the differential intraocular pressure response (IOP) to dexamethasone (DEX) treatment at two dose levels (100 or 500 nM) in perfusion cultured Indian cadaveric eyes to investigate glucocorticoid (GC) responsiveness. In a human organ-cultured anterior segment (HOCAS) set-u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80112-8
更新日期：2021-01-12 00:00:00
abstract：:Transposable elements are emerging as an important source of cis-acting regulatory sequences and epigenetic marks that could influence gene expression. However, few studies have dissected the role of specific transposable element insertions on epigenetic gene regulation. Bari-Jheh is a natural transposon that mediates...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30491-w
更新日期：2018-08-15 00:00:00
abstract：:Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF580, GEFT and a recently discovered longer isoform of 619 amino acids (p63RhoGEF619). The subc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36825
更新日期：2016-11-11 00:00:00
abstract：:Lung cancer is the foremost cause of cancer related deaths in the U.S. It is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells surrounded by heterotypic cells and extracellular matrix dynamically interacting with the tumor cells. Research in lung cancer is often restricted to pati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41301-2
更新日期：2019-03-20 00:00:00
abstract：:The critical role of the regulatory elements at the 5' end of the HIV-1 genome in controlling the life cycle of HIV-1 indicates that this region significantly influences virus fitness and its biological properties. In this study, we performed a detailed characterization of strain-specific variability of sequences from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70083-1
更新日期：2020-08-06 00:00:00
abstract：:Solitons are of fundamental importance in photonics due to applications in optical data transmission and also as a tool for investigating novel phenomena ranging from light generation at new frequencies and wave-trapping to rogue waves. Solitons are also moving scatterers: they generate refractive index perturbations ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00932
更新日期：2012-01-01 00:00:00
abstract：:Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08900-3
更新日期：2017-08-17 00:00:00
abstract：:As whales recover from commercial exploitation, they are increasing in abundance in habitats that they have been absent from for decades. However, studying the recovery and habitat use patterns of whales, particularly in remote and inaccessible regions, frequently poses logistical and economic challenges. Here we tria...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69887-y
更新日期：2020-07-31 00:00:00
abstract：:Diabetic nephropathy, the major cause of chronic kidney disease, is associated with progressive renal fibrosis. Recently, accumulation of periostin, an extracellular matrix protein, was shown to augment renal fibrosis. Aptamers have higher binding affinities without developing the common side effects of antibodies. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09238-6
更新日期：2017-08-17 00:00:00
abstract：:Detailed structural analyses of the mushroom body which plays critical roles in olfactory learning and memory revealed that it is directly connected with multiple primary sensory centers in Drosophila. Connectivity patterns between the mushroom body and primary sensory centers suggest that each mushroom body lobe proc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29481
更新日期：2016-07-11 00:00:00
abstract：:Species in the genus Suaeda have few diagnostic characters and substantial morphological plasticity. Hence, regional floras do not provide clear taxonomic information for Suaeda spp. in East Asia. In order to assess the taxonomy of four species in the genus Suaeda (S. australis, S. maritima, S. japonica, and S. hetero...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78041-7
更新日期：2020-12-01 00:00:00
abstract：:The ability to convert photons of different wavelengths directly into mechanical motion is of significant interest in many energy conversion and reconfigurable technologies. Here, using few layer 2H-MoS2 nanosheets, layer by layer process of nanocomposite fabrication, and strain engineering, we demonstrate a reversibl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34831
更新日期：2016-10-07 00:00:00
abstract：:The honey bee is threatened by biological agents and pesticides that can act in combination to induce synergistic effects on its physiology and lifespan. The synergistic effects of a parasite/pesticide combination have been demonstrated on workers and queens, but no studies have been performed on drones despite their ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08380-5
更新日期：2017-08-17 00:00:00
abstract：:Centrioles are essential for forming cilia, flagella and centrosomes. Successful centriole assembly requires proteins of the SAS-6 family, which can form oligomeric ring structures with ninefold symmetry in vitro. While important progress has been made in understanding SAS-6 protein biophysics, the mechanisms enabling...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27075
更新日期：2016-06-08 00:00:00
abstract：:The purpose was to evaluate intra and inter-rater reliability, repeatability and absolute accuracy between ultrasound imaging (US) and caliper measures to determine Spring ligament (SL) dimensions in cadavers. SLs were identified from 62 human feet from formaldehyde-embalmed cadavers. Intra and inter-observer reliabil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51384-6
更新日期：2019-10-15 00:00:00
