Abstract：
:The synaptic protein SHANK3 encodes a multidomain scaffold protein expressed at the postsynaptic density of neuronal excitatory synapses. We previously identified de novo SHANK3 mutations in patients with autism spectrum disorders (ASD) and showed that SHANK3 represents one of the major genes for ASD. Here, we analyzed the pyramidal cortical neurons derived from induced pluripotent stem cells from four patients with ASD carrying SHANK3 de novo truncating mutations. At 40-45 days after the differentiation of neural stem cells, dendritic spines from pyramidal neurons presented variable morphologies: filopodia, thin, stubby and muschroom, as measured in 3D using GFP labeling and immunofluorescence. As compared to three controls, we observed a significant decrease in SHANK3 mRNA levels (less than 50% of controls) in correlation with a significant reduction in dendritic spine densities and whole spine and spine head volumes. These results, obtained through the analysis of de novo SHANK3 mutations in the patients' genomic background, provide further support for the presence of synaptic abnormalities in a subset of patients with ASD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gouder L,Vitrac A,Goubran-Botros H,Danckaert A,Tinevez JY,André-Leroux G,Atanasova E,Lemière N,Biton A,Leblond CS,Poulet A,Boland A,Deleuze JF,Benchoua A,Delorme R,Bourgeron T,Cloëz-Tayarani Idoi
10.1038/s41598-018-36993-xsubject
Has Abstractpub_date
2019-01-14 00:00:00pages
94issue
1issn
2045-2322pii
10.1038/s41598-018-36993-xjournal_volume
9pub_type
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