Protein-protein interaction network analysis applied to DNA copy number profiling suggests new perspectives on the aetiology of Mayer-Rokitansky-Küster-Hauser syndrome.

abstract：:Three-dimensional integrated circuits (3D ICs) are an attractive replacement for conventional 2D ICs as high-performance, low-power-consumption, and small-footprint microelectronic devices. However, one of the major remaining challenges is the manufacture of high-aspect-ratio through-silicon vias (TSVs), which is a cr...

journal_title：Scientific reports

authors： He F,Yu J,Tan Y,Chu W,Zhou C,Cheng Y,Sugioka K

更新日期：2017-01-18 00:00:00

abstract：:Surfactant solutions typically feature tunable nanoscale, internal structures. Although rarely utilized, they can be a powerful platform for probing thermal transport in nanoscale domains and across interfaces with nanometer-size radius. Here, we examine the structure and thermal transport in solution of AOT (Dioctyl ...

journal_title：Scientific reports

authors： Cao F,Liu Y,Xu J,He Y,Hammouda B,Qiao R,Yang B

更新日期：2015-11-04 00:00:00

abstract：:Glucose homeostasis is regulated by insulin, which is produced in the β-cells of the pancreas. The synthesis of insulin is controlled by several transcription factors including PDX-1, USF1 and USF2. Both, PDX-1 and USF1 were identified as substrates for protein kinase CK2. Here, we have analysed the interplay of PDX-1...

journal_title：Scientific reports

authors： Spohrer S,Groß R,Nalbach L,Schwind L,Stumpf H,Menger MD,Ampofo E,Montenarh M,Götz C

更新日期：2017-11-27 00:00:00

abstract：:Kidney regeneration from pluripotent stem cells is receiving a lot of attention because limited treatments are currently available for chronic kidney disease (CKD). It has been shown that uremic state in CKD is toxic to somatic stem/progenitor cells, such as endothelial progenitor and mesenchymal stem cells, affecting...

journal_title：Scientific reports

authors： Tajiri S,Yamanaka S,Fujimoto T,Matsumoto K,Taguchi A,Nishinakamura R,Okano HJ,Yokoo T

更新日期：2018-10-08 00:00:00

abstract：:Hepatitis C virus (HCV) uses components of the very-low-density lipoprotein (VLDL) pathway for assembly/release. We previously reported that hepatocyte nuclear factor 4α (HNF4α) participates in HCV assembly/release through downstream factors those participate in VLDL assembly/secretion. Cell-death-inducing DFFA-like e...

journal_title：Scientific reports

authors： Cai H,Yao W,Li L,Li X,Hu L,Mai R,Peng T

更新日期：2016-06-10 00:00:00

abstract：:Drug repositioning strategies have improved substantially in recent years. At present, two advances are poised to facilitate new strategies. First, the LINCS project can provide rich transcriptome data that reflect the responses of cells upon exposure to various drugs. Second, machine learning algorithms have been app...

journal_title：Scientific reports

authors： Xie L,He S,Wen Y,Bo X,Zhang Z

更新日期：2017-08-02 00:00:00

abstract：:Atmospheric-pressure N2, He, air, and O2 microplasma arrays have been used to investigate the effects of plasma treatment on seed germination and seedling growth of mung bean in aqueous solution. Seed germination and growth of mung bean were found to strongly depend on the feed gases used to generate plasma and plasma...

journal_title：Scientific reports

authors： Zhou R,Zhou R,Zhang X,Zhuang J,Yang S,Bazaka K,Ken Ostrikov K

更新日期：2016-09-01 00:00:00

abstract：:The synthetic Angiotensin Converting Enzyme (ACE) inhibitors have side effects and hence demands for natural ACE inhibitors have been rising. The aim of this study is to purify and introduce natural ACE inhibitors extracted from Zizyphus jujuba fruits. Proteins from Zizyphus jujuba were lysed by trypsin, papain and th...

journal_title：Scientific reports

authors： Memarpoor-Yazdi M,Zare-Zardini H,Mogharrab N,Navapour L

更新日期：2020-03-04 00:00:00

abstract：:The most consistent sex differences in cognition are found for spatial ability, in which males, on average, outperform females. Utilizing a twin design, two studies have shown that females with male co-twins perform better than females with female co-twins on a mental rotation task. According to the Twin Testosterone ...

journal_title：Scientific reports

authors： Toivainen T,Pannini G,Papageorgiou KA,Malanchini M,Rimfeld K,Shakeshaft N,Kovas Y

更新日期：2018-09-12 00:00:00

abstract：:The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...

journal_title：Scientific reports

authors： Koblischke M,Mackroth MS,Schwaiger J,Fae I,Fischer G,Stiasny K,Heinz FX,Aberle JH

更新日期：2017-08-21 00:00:00

abstract：:The present work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF). In vivo liver fibrosis in mice was induced by an alcoholic liquid diet, and in vitro studies were performed on activated HSC-T6 and LX2 cells treated with lipopolysaccharide. Our results sh...

journal_title：Scientific reports

authors： Liu M,Xu Y,Han X,Yin L,Xu L,Qi Y,Zhao Y,Liu K,Peng J

更新日期：2015-12-10 00:00:00

abstract：:Scaling up atmospheric pressure glow discharge to large volume is desirable for low-temperature plasma applications. In this paper, an approach to generate a glow discharge in a planar shape with a fairly large volume is proposed in atmospheric pressure air through utilizing a direct-current excited rod array electrod...

journal_title：Scientific reports

authors： Li X,Zhang P,Jia P,Chu J,Chen J

更新日期：2017-06-01 00:00:00

abstract：:It is a common belief that reptile eggs should not be turned after oviposition once the embryo has attached itself to the inner membrane of the shell as it might kill developing embryos. Here, we used 338 eggs from 32 clutches of the water snake Natrix maura to (1) thoroughly describe natural clutch arrangement, (2) e...

journal_title：Scientific reports

authors： Aubret F,Blanvillain G,Kok PJ

更新日期：2015-08-21 00:00:00

abstract：:Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, ...

journal_title：Scientific reports

authors： Baye E,de Courten MP,Walker K,Ranasinha S,Earnest A,Forbes JM,de Courten B

更新日期：2017-06-23 00:00:00

abstract：:We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular structures, as optimization of this component removes the need for heteroty...

journal_title：Scientific reports

authors： Hagiwara M,Peng F,Ho CM

更新日期：2015-01-27 00:00:00

abstract：:Male infertility is a worldwide medical problem. Asthenozoospermia is a common cause of infertility. Epigenetic modifications of DNA and histones have been shown to influence human infertility, but no research has explored whether N(6)-methyladenosine (m(6)A) level in RNA is associated with asthenozoospermia. Here, we...

journal_title：Scientific reports

authors： Yang Y,Huang W,Huang JT,Shen F,Xiong J,Yuan EF,Qin SS,Zhang M,Feng YQ,Yuan BF,Liu SM

更新日期：2016-04-13 00:00:00

abstract：:Altering mechanical compliance in load carriage structures has shown to reduce metabolic cost and accelerative forces of carrying weight. Currently, modifications to load carriage structures have been primarily targeted at vertical motion of the carried mass. No study to date has investigated altering load carriage co...

journal_title：Scientific reports

authors： Martin JP,Li Q

更新日期：2018-09-13 00:00:00

abstract：:Parkinson's disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully explored. This study explored multi-modal PD neuroimaging and its application for predicting clinical scores on the Movement Disorder Society...

journal_title：Scientific reports

authors： Son SJ,Kim M,Park H

更新日期：2016-11-30 00:00:00

abstract：:Platelet transfusions can cause adverse reactions in their recipients, including transfusion-related acute lung injury (TRALI). The pathophysiology of TRALI depends on a number of signaling pathways and the inflammatory role played by blood platelets remains controversial. Platelets are important in inflammation, part...

journal_title：Scientific reports

authors： Tariket S,Hamzeh-Cognasse H,Laradi S,Arthaud CA,Eyraud MA,Bourlet T,Berthelot P,Garraud O,Cognasse F

更新日期：2019-08-29 00:00:00

abstract：:EU biodiversity conservation policy is based on the Habitats Directive (92/43/EC), which aims that habitat types and species of Community interest should reach 'favourable conservation status'. To this end, Member States are obliged to perform periodic assessment of species and habitat conservation status through biod...

journal_title：Scientific reports

authors： Kallimanis AS,Panitsa M,Dimopoulos P

更新日期：2017-08-21 00:00:00

abstract：:In everyday life, people must often determine how much time and effort to allocate to cooperative activities. In the current study, we tested the hypothesis that the perception of others' effort investment in a cooperative activity may elicit a sense of commitment, leading people to allocate more time and effort to th...

journal_title：Scientific reports

authors： Chennells M,Michael J

更新日期：2018-10-24 00:00:00

abstract：:In this paper, we propose a novel bio-compatible organic humidity sensor based on natural inner egg shell membrane (IESM) with multilayer cross linked fiber structure that can be used as a substrate as well as a sensing active layer. To fabricate the proposed sensors, two different size inter digital electrodes (IDEs)...

journal_title：Scientific reports

authors： Khan MU,Hassan G,Bae J

更新日期：2019-04-09 00:00:00

abstract：:Methanol (MOH) and monomethylamine (MMA) are two typical one-carbon (C1) compounds found in natural environments. They play an important role in marine and atmospheric chemistry, cloud formation, and global climate. The main biological sink of MOH and MMA is rapid consumption by marine microbes. Here, field-based time...

journal_title：Scientific reports

authors： Deng W,Peng L,Jiao N,Zhang Y

更新日期：2018-10-18 00:00:00

abstract：:Hydrogen sulfide is the third and most recently discovered gaseous signaling molecule following nitric oxide and carbon monoxide, playing important roles both in normal physiological conditions and disease progression. The trimethylsulfonium ion (TMS) can result from successive methylation reactions of hydrogen sulfid...

journal_title：Scientific reports

authors： Lajin B,Francesconi KA

更新日期：2016-06-01 00:00:00

abstract：:We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel, whereas dendrites and soma remain predominantly in the somal co...

journal_title：Scientific reports

authors： Spijkers XM,Pasteuning-Vuhman S,Dorleijn JC,Vulto P,Wevers NR,Pasterkamp RJ

更新日期：2021-01-22 00:00:00

abstract：:Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and cat...

journal_title：Scientific reports

authors： Dragset MS,Ioerger TR,Zhang YJ,Mærk M,Ginbot Z,Sacchettini JC,Flo TH,Rubin EJ,Steigedal M

更新日期：2019-08-06 00:00:00

abstract：:Identification of epitopes for integrin-blocking monoclonal antibodies (mAbs) has aided our understanding of structure-function relationship of integrins. We mapped epitopes of chicken anti-integrin-α8-subunit-blocking mAbs by mutational analyses, examining regions that harboured all mapped epitopes recognized by mAbs...

journal_title：Scientific reports

authors： Nishimichi N,Kawashima N,Yokosaki Y

更新日期：2015-09-09 00:00:00

abstract：:The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family proteins bind RNA and single-stranded DNA, and create C-to-U base modifications through cytidine deaminase activity. APOBEC3G restricts human immunodeficiency virus 1 (HIV-1) infection by creating hypermutations in proviral DNA, while HIV-1-e...

journal_title：Scientific reports

authors： Chen R,Zhao X,Wang Y,Xie Y,Liu J

更新日期：2017-01-18 00:00:00

abstract：:ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To the best of our knowledge, no inhibitors of IdeR are identified. We carried out virtual screening of NCI database against the IdeR DNA binding d...

journal_title：Scientific reports

authors： Rohilla A,Khare G,Tyagi AK

更新日期：2017-07-05 00:00:00

abstract：:Heterogeneous catalysis, which is widely used in the chemical industry, makes a great use of supported late-transition-metal nanoparticles, and bimetallic catalysts often show superior catalytic performances as compared to their single metal counterparts. In order to optimize catalyst efficiency and discover new activ...

journal_title：Scientific reports

authors： Piccolo L,Li ZY,Demiroglu I,Moyon F,Konuspayeva Z,Berhault G,Afanasiev P,Lefebvre W,Yuan J,Johnston RL

更新日期：2016-10-14 00:00:00