Attentional Control in Adolescent Mice Assessed with a Modified Five Choice Serial Reaction Time Task.

abstract：:P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We charac...

journal_title：Scientific reports

authors： Wisniewski L,French V,Lockwood N,Valdivia LE,Frankel P

更新日期：2020-09-24 00:00:00

abstract：:Ancestry informative single nucleotide polymorphisms (SNPs) can identify biogeographic ancestry (BGA); however, population substructure and relatively recent admixture can make differentiation difficult in heterogeneous Hispanic populations. Utilizing unrelated individuals from the Genomic Origins and Admixture in Lat...

journal_title：Scientific reports

authors： Setser CH,Planz JV,Barber RC,Phillips NR,Chakraborty R,Cross DS

更新日期：2020-05-08 00:00:00

abstract：:Fire blight, caused by the enterobacterium Erwinia amylovora, is a destructive disease, which can affect most members of the Rosaceae family. Since no significant genomic differences have been found by others to explain differences in virulence, we used here a gel-based proteomic approach to elucidate mechanisms and k...

journal_title：Scientific reports

authors： Holtappels M,Noben JP,Van Dijck P,Valcke R

更新日期：2018-08-03 00:00:00

abstract：:There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile metabolic compounds may provide an approach for noninvasive early diagnosis of malignant diseases. Here we analyz...

journal_title：Scientific reports

authors： He J,Sinues PM,Hollmén M,Li X,Detmar M,Zenobi R

更新日期：2014-06-06 00:00:00

abstract：:Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined...

journal_title：Scientific reports

authors： Shiba K,Tsuchiya K,Komiya C,Miyachi Y,Mori K,Shimazu N,Yamaguchi S,Ogasawara N,Katoh M,Itoh M,Suganami T,Ogawa Y

更新日期：2018-02-05 00:00:00

abstract：:An effective analysis method was developed based on a chemometric tool for the simultaneous quantification of five different post-harvest pesticides (2,4-dichlorophenoxyacetic acid (2,4-D), carbendazim, thiabendazole, iprodione, and prochloraz) in fruits and vegetables. In the modified QuEChERS (quick, easy, cheap, ef...

journal_title：Scientific reports

authors： Li M,Dai C,Wang F,Kong Z,He Y,Huang YT,Fan B

更新日期：2017-02-22 00:00:00

abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...

journal_title：Scientific reports

authors： Law BY,Chan WK,Xu SW,Wang JR,Bai LP,Liu L,Wong VK

更新日期：2014-07-01 00:00:00

abstract：:Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) an...

journal_title：Scientific reports

authors： Schofield ZV,Croker D,Robertson AAB,Massey NL,Donovan C,Tee E,Edwards D,Woodruff TM,Halai R,Hansbro PM,Cooper MA

更新日期：2018-12-13 00:00:00

abstract：:A multi-angle light scattering (MALS) system, combined with chromatographic separation, directly measures the absolute molar mass, size and concentration of the eluate species. The measurement of these crucial properties in solution is essential in basic macromolecular characterization and all research and production ...

journal_title：Scientific reports

authors： Hsieh VH,Wyatt PJ

更新日期：2017-08-30 00:00:00

abstract：:B-cell receptor (BCR) signaling plays a critical role in B-cell activation and humoral immunity. In this study, we discovered a critical function of leucine-rich repeat kinase 1 (LRRK1) in BCR-mediated immune responses. Lrrk1(-/-) mice exhibited altered B1a-cell development and basal immunoglobulin production. In addi...

journal_title：Scientific reports

authors： Morimoto K,Baba Y,Shinohara H,Kang S,Nojima S,Kimura T,Ito D,Yoshida Y,Maeda Y,Sarashina-Kida H,Nishide M,Hosokawa T,Kato Y,Hayama Y,Kinehara Y,Okuno T,Takamatsu H,Hirano T,Shima Y,Narazaki M,Kurosaki T,Toyofuku

更新日期：2016-05-11 00:00:00

abstract：:The characterization of network community structure has profound implications in several scientific areas. Therefore, testing the algorithms developed to establish the optimal division of a network into communities is a fundamental problem in the field. We performed here a highly detailed evaluation of community detec...

journal_title：Scientific reports

authors： Aldecoa R,Marín I

更新日期：2013-01-01 00:00:00

abstract：:The autonomic nervous system (ANS) regulates tissue homeostasis and remodelling through antagonistic effects of noradrenergic sympathetic and cholinergic parasympathetic signalling. Despite numerous reports on the induction of sympathetic neurons from human pluripotent stem cells (hPSCs), no induction methods have eff...

journal_title：Scientific reports

authors： Takayama Y,Kushige H,Akagi Y,Suzuki Y,Kumagai Y,Kida YS

更新日期：2020-06-11 00:00:00

abstract：:Alternative oxidase (AOX) is a mitochondrial inner-membrane oxidase that accepts electrons directly from ubiquinol and reduces oxygen to water without involving cytochrome-linked electron transport chain. It is highly conserved in many non-vertebrate taxa and may protect cells against hypoxia and oxidative stress. We ...

journal_title：Scientific reports

authors： Liu M,Guo X

更新日期：2017-09-07 00:00:00

abstract：:Floating macrophytes, including water hyacinth (Eichhornia crassipes), are dominant invasive organisms in tropical aquatic systems, and they may play an important role in modifying the gas exchange between water and the atmosphere. However, these systems are underrepresented in global datasets of greenhouse gas (GHG) ...

journal_title：Scientific reports

authors： Attermeyer K,Flury S,Jayakumar R,Fiener P,Steger K,Arya V,Wilken F,van Geldern R,Premke K

更新日期：2016-02-05 00:00:00

abstract：:A patient's pain during mandibular third molar extraction often creates problems for a dental surgeon and can also cause immense patient discomfort, such as decreased quality of life, serious complications, or even danger to the patients' lives. Effective pain management is therefore of great importance. Conventional ...

journal_title：Scientific reports

authors： Yu F,Xiao Y,Liu H,Wu F,Lou F,Chen D,Bai M,Huang D,Wang C,Ye L

更新日期：2017-01-20 00:00:00

abstract：:Corticotropin releasing factor (CRF), a peptide hormone involved in the stress response, holds a key position in cardiovascular regulation. Here, we report that the central effect of CRF on cardiovascular activities is mediated by the posterior hypothalamic nucleus (PH), an important structure responsible for stress-i...

journal_title：Scientific reports

authors： Gao HR,Zhuang QX,Li B,Li HZ,Chen ZP,Wang JJ,Zhu JN

更新日期：2016-02-01 00:00:00

abstract：:Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis are the hypothesized cause. Understanding which molecular processes regulate hippocampal progenitor differentiation might aid in the identification of novel drug targets that can promote larger hippocampal vol...

journal_title：Scientific reports

authors： Powell TR,Murphy T,Lee SH,Duarte RRR,Lee HA,Smeeth D,Price J,Breen G,Thuret S

更新日期：2017-11-08 00:00:00

abstract：:In this work, we introduce a novel and facile method of exfoliating large-area, single-layer graphene oxide using a shearing stress. The shearing stress reactor consists of two concentric cylinders, where the inner cylinder rotates at controlled speed while the outer cylinder is kept stationary. We found that the form...

journal_title：Scientific reports

authors： Park WK,Yoon Y,Song YH,Choi SY,Kim S,Do Y,Lee J,Park H,Yoon DH,Yang WS

更新日期：2017-11-27 00:00:00

abstract：:Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibi...

journal_title：Scientific reports

authors： Cheng JY,Zhang T,Alley MT,Uecker M,Lustig M,Pauly JM,Vasanawala SS

更新日期：2017-07-13 00:00:00

abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Giancardo L,Sánchez-Ferro A,Arroyo-Gallego T,Butterworth I,Mendoza CS,Montero P,Matarazzo M,Obeso JA,Gray ML,Estépar RSJ

更新日期：2018-10-16 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Sagers JE,Brown AS,Vasilijic S,Lewis RM,Sahin MI,Landegger LD,Perlis RH,Kohane IS,Welling DB,Patel CJ,Stankovic KM

更新日期：2018-11-23 00:00:00

abstract：:Recent reports on direct reprogramming of cancer cells (iPCs) which results in reduced tumorigenic potential has attributed the importance of epigenetics in tumorigenesis, but lacked genome-wide analysis. Here we describe successful generation of iPCs from non-small cell lung cancer (NSCLC) cell lines. Following repro...

journal_title：Scientific reports

authors： Mahalingam D,Kong CM,Lai J,Tay LL,Yang H,Wang X

更新日期：2012-01-01 00:00:00

abstract：:Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and a...

journal_title：Scientific reports

authors： Lin TC,Chen JC,Liu CH,Lee CY,Tsou YA,Chuang CC

更新日期：2017-12-05 00:00:00

abstract：:Up to 90% of people with neurological deficits following whiplash injury report chronic symptoms. A recent unique study of neck-specific exercise showed positive results (post-intervention at 12 weeks), regarding arm pain and neurological deficits in people with chronic whiplash associated disorders (WAD). This 1-year...

journal_title：Scientific reports

authors： Ludvigsson ML,Peterson G,Peolsson A

更新日期：2020-04-21 00:00:00

abstract：:A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with...

journal_title：Scientific reports

authors： Benoit RM,Schärer MA,Wieser MM,Li X,Frey D,Kammerer RA

更新日期：2017-03-02 00:00:00

abstract：:Working with a large temporal dataset spanning several decades often represents a challenging task, especially when the record is heterogeneous and incomplete. The use of statistical laws could potentially overcome these problems. Here we apply Benford's Law (also called the "First-Digit Law") to the traveled distance...

journal_title：Scientific reports

authors： Joannes-Boyau R,Bodin T,Scheffers A,Sambridge M,May SM

更新日期：2015-07-09 00:00:00

abstract：:Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH)...

journal_title：Scientific reports

authors： Rendo V,Kundu S,Rameika N,Ljungström V,Svensson R,Palin K,Aaltonen L,Stoimenov I,Sjöblom T

更新日期：2020-12-31 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment. As part of it, pancreatic stellate cells (PSCs) provide a fibrotic niche, stimulated by a dynamic communication between activated PSCs and tumour cells. Investigating how PSCs contribute to tumour development and for identifying...

journal_title：Scientific reports

authors： Marzoq AJ,Mustafa SA,Heidrich L,Hoheisel JD,Alhamdani MSS

更新日期：2019-03-28 00:00:00

abstract：:Social context influences social decisions and outcome processing, partially depending on inter-individual differences. The present study investigated social context-dependent modulation of behavior and feedback processing in the ultimatum game (UG) in relation to inter-individual differences in social anxiety. Thirty...

journal_title：Scientific reports

authors： Peterburs J,Voegler R,Liepelt R,Schulze A,Wilhelm S,Ocklenburg S,Straube T

更新日期：2017-03-09 00:00:00

abstract：:Males of hymenopteran insects, which include ants, bees and wasps, develop as haploids from unfertilized eggs. In order to accommodate their lack of homologous chromosome pairs, some hymenopterans such as the honeybee have been shown to produce haploid sperm through an abortive meiosis. We employed microscopic approac...

journal_title：Scientific reports

authors： Ferree PM,Aldrich JC,Jing XA,Norwood CT,Van Schaick MR,Cheema MS,Ausió J,Gowen BE

更新日期：2019-08-21 00:00:00