LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.

abstract：:In a developing nervous system, endogenous electric field (EF) influence embryonic growth. We reported the EF-directed migration of both rat Schwann cells (SCs) and oligodendrocyte precursor cells (OPCs) and explored the molecular mechanism using RNA-sequencing assay. However, previous studies revealed the differentia...

journal_title：Scientific reports

authors： Yao L,Shippy T,Li Y

更新日期：2020-10-08 00:00:00

abstract：:Functional brain connectivity is altered during the pathological processes of Alzheimer's disease (AD), but the specific evolutional rules are insufficiently understood. Resting-state functional magnetic resonance imaging indicates that the functional brain networks of individuals with AD tend to be disrupted in hub-l...

journal_title：Scientific reports

authors： Li W,Wang M,Zhu W,Qin Y,Huang Y,Chen X

更新日期：2016-09-28 00:00:00

abstract：:Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and comorbidities in the general population are different from those inside the disaster areas. The present study estimated incident PTSD and comorbid d...

journal_title：Scientific reports

authors： Chang JC,Yen AM,Chen HH,Chen SL,Chiu SY,Fann JC,Lee CS

更新日期：2017-01-27 00:00:00

abstract：:A larger amount of sequence data in private and public databases produced by next-generation sequencing put new challenges due to limitation associated with the alignment-based method for sequence comparison. So, there is a high need for faster sequence analysis algorithms. In this study, we developed an alignment-fre...

journal_title：Scientific reports

authors： Saw AK,Raj G,Das M,Talukdar NC,Tripathy BC,Nandi S

更新日期：2019-03-06 00:00:00

abstract：:Aggression and responsiveness to noxious stimuli are adaptable traits that are ubiquitous throughout the animal kingdom. Like vertebrate animals, some invertebrates have been shown to exhibit anxiety-like behaviour and altered levels of aggression that are modulated by the neurotransmitter serotonin. To investigate wh...

journal_title：Scientific reports

authors： Hamilton TJ,Kwan GT,Gallup J,Tresguerres M

更新日期：2016-01-25 00:00:00

abstract：:The programmed induction of meiotic DNA double-strand breaks (DSBs) by the evolutionarily conserved SPO-11 protein, which is structurally related to archaeal Topo VIA topoisomerases, triggers meiotic recombination. Identification of several meiosis-specific factors that are required for SPO-11-mediated DSB formation r...

journal_title：Scientific reports

authors： Yeh HY,Lin SW,Wu YC,Chan NL,Chi P

更新日期：2017-05-24 00:00:00

abstract：:The role of soil organic carbon in global carbon cycles is receiving increasing attention both as a potentially large and uncertain source of CO2 emissions in response to predicted global temperature rises, and as a natural sink for carbon able to reduce atmospheric CO2. There is general agreement that the technical p...

journal_title：Scientific reports

authors： Zomer RJ,Bossio DA,Sommer R,Verchot LV

更新日期：2017-11-14 00:00:00

abstract：:Cystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake mechanisms remain largely unexplored. Recently, we demonstrated that the cystine-knot peptide EETI-...

journal_title：Scientific reports

authors： Gao X,De Mazière A,Iaea DB,Arthur CP,Klumperman J,Ciferri C,Hannoush RN

更新日期：2019-05-06 00:00:00

abstract：:Strategic delivery of IRDye 700DX (photosensitizer) is a key for improving its effect in photodynamic therapy. In this study, we have synthesized IRDye 700DX-conjugated polymers containing multiple cyclic RGD peptides to deliver IRDye 700DX selectively to tumor cells and tumor-associated blood vessels overexpressing α...

journal_title：Scientific reports

authors： Dou X,Nomoto T,Takemoto H,Matsui M,Tomoda K,Nishiyama N

更新日期：2018-05-25 00:00:00

abstract：:The optical conversion of incoherent solar radiation into a bright, coherent laser beam enables the application of nonlinear optics to solar energy conversion and storage. Here, we present an architecture for solar pumped lasers that uses a luminescent solar concentrator to decouple the conventional trade-off between ...

journal_title：Scientific reports

authors： Reusswig PD,Nechayev S,Scherer JM,Hwang GW,Bawendi MG,Baldo MA,Rotschild C

更新日期：2015-10-05 00:00:00

abstract：:Tomatoes are known to have ameliorative effects on cardiovascular disease and cancer. The nutritional value of tomatoes can be enhanced by increasing flavonoids content through genetic modification. The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoi...

journal_title：Scientific reports

authors： Lim W,Li J

更新日期：2017-09-28 00:00:00

abstract：:Inorganic semiconductors such as III-V materials are very important in our everyday life as they are used for manufacturing optoelectronic and microelectronic components with important applications span from energy harvesting to telecommunications. In some applications, these components are required to operate in hars...

journal_title：Scientific reports

authors： Ng WH,Lu Y,Liu H,Carmalt CJ,Parkin IP,Kenyon AJ

更新日期：2018-02-23 00:00:00

abstract：:Electrochemical capacitors (EC) have received tremendous interest due to their high potential to satisfy the urgent demand in many advanced applications. The development of new electrode materials is considered to be the most promising approach to enhance the EC performance substantially. Herein, we present a high-cap...

journal_title：Scientific reports

authors： Zhou J,Li N,Gao F,Zhao Y,Hou L,Xu Z

更新日期：2014-08-15 00:00:00

abstract：:Alveolar β2-receptor blockade worsens lung diffusion in heart failure (HF). This effect could be mitigated by stimulating alveolar β2-receptors. We investigated the safety and the effects of indacaterol on lung diffusion, lung mechanics, sleep respiratory behavior, cardiac rhythm, welfare, and exercise performance in ...

journal_title：Scientific reports

authors： Contini M,Spadafora E,Barbieri S,Gugliandolo P,Salvioni E,Magini A,Apostolo A,Palermo P,Alimento M,Agostoni P

更新日期：2020-04-28 00:00:00

abstract：:Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzy...

journal_title：Scientific reports

authors： Qiao L,Du M,Liang X,Hao Y,He X,Si F,Mei T,Chen B

更新日期：2016-07-15 00:00:00

abstract：:Surfactant solutions typically feature tunable nanoscale, internal structures. Although rarely utilized, they can be a powerful platform for probing thermal transport in nanoscale domains and across interfaces with nanometer-size radius. Here, we examine the structure and thermal transport in solution of AOT (Dioctyl ...

journal_title：Scientific reports

authors： Cao F,Liu Y,Xu J,He Y,Hammouda B,Qiao R,Yang B

更新日期：2015-11-04 00:00:00

abstract：:Cellular therapies for liver diseases and in vitro models for drug testing both require functional human hepatocytes (Hum-H), which have unfortunately been limited due to the paucity of donor liver tissues. Human pluripotent stem cells (hPSCs) represent a promising and potentially unlimited cell source to derive Hum-H...

journal_title：Scientific reports

authors： Song W,Lu YC,Frankel AS,An D,Schwartz RE,Ma M

更新日期：2015-11-23 00:00:00

abstract：:Polymersome nanoparticles (PMs) are attractive candidates for spatio-temporal controlled delivery of therapeutic agents. Although many studies have addressed cellular uptake of solid nanoparticles, there is very little data available on intracellular release of molecules encapsulated in membranous carriers, such as po...

journal_title：Scientific reports

authors： Scarpa E,Bailey JL,Janeczek AA,Stumpf PS,Johnston AH,Oreffo RO,Woo YL,Cheong YC,Evans ND,Newman TA

更新日期：2016-07-11 00:00:00

abstract：:Hydrophilic polymers have garnered much attention due to their critical roles in various applications such as molecular separation membranes, bio-interfaces, and surface engineering. However, a long-standing problem is that their mechanical properties usually deteriorate at high relative humidity (RH). Through the sim...

journal_title：Scientific reports

authors： Liu T,An QF,Zhao Q,Wu JK,Song YH,Zhu BK,Gao CJ

更新日期：2015-01-14 00:00:00

abstract：:Lung fibrosis is an unabated wound healing response characterized by the loss and aberrant function of lung epithelial cells. Herein, we report that extracellular Clusterin promoted epithelial cell apoptosis whereas intracellular Clusterin maintained epithelium viability during lung repair. Unlike normal and COPD lung...

journal_title：Scientific reports

authors： Habiel DM,Camelo A,Espindola M,Burwell T,Hanna R,Miranda E,Carruthers A,Bell M,Coelho AL,Liu H,Pilataxi F,Clarke L,Grant E,Lewis A,Moore B,Knight DA,Hogaboam CM,Murray LA

更新日期：2017-11-13 00:00:00

abstract：:With the objective to conceive a plasmonic solar cell with enhanced photocurrent, we investigate the role of plasmonic nanoshells, embedded within a ultrathin microcrystalline silicon solar cell, in enhancing broadband light trapping capability of the cell and, at the same time, to reduce the parasitic loss. The thick...

journal_title：Scientific reports

authors： Raja W,Bozzola A,Zilio P,Miele E,Panaro S,Wang H,Toma A,Alabastri A,De Angelis F,Zaccaria RP

更新日期：2016-04-15 00:00:00

abstract：:In the highly interconnected architectures of the cerebral cortex, recurrent intracortical loops disproportionately outnumber thalamo-cortical inputs. These networks are also capable of generating neuronal activity without feedforward sensory drive. It is unknown, however, what spatiotemporal patterns may be solely at...

journal_title：Scientific reports

authors： Kodama NX,Feng T,Ullett JJ,Chiel HJ,Sivakumar SS,Galán RF

更新日期：2018-01-12 00:00:00

abstract：:Emerging infectious diseases such as chytridiomycosis and ranavirus infections are important contributors to the worldwide decline of amphibian populations. We reviewed data on 247 anuran mortality events in 43 States of the United States from 1999-2015. Our findings suggest that a severe infectious disease of tadpole...

journal_title：Scientific reports

authors： Isidoro-Ayza M,Lorch JM,Grear DA,Winzeler M,Calhoun DL,Barichivich WJ

更新日期：2017-08-31 00:00:00

abstract：:Salinity is one of the major abiotic factors that affect productivity in oat. Here, we report a comparison of the transcriptomes of two hexaploid oat cultivars, 'Hanyou-5' and 'Huazao-2', which differ with respect to salt tolerance, in seedlings exposed to salt stress. Analysis of the assembled unigenes from the osmot...

journal_title：Scientific reports

authors： Wu B,Munkhtuya Y,Li J,Hu Y,Zhang Q,Zhang Z

更新日期：2018-11-02 00:00:00

abstract：:Toxins are believed to play a crucial role in Burkholderia pseudomallei pathogenicity, however to date, only a few have been identified. The discovery of additional toxic molecules is limited by the lack of a sensitive indicator of B. pseudomallei toxicity. Previously, from a whole genome transcriptome analysis of B. ...

journal_title：Scientific reports

authors： Wong RR,Kong C,Lee SH,Nathan S

更新日期：2016-06-07 00:00:00

abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...

journal_title：Scientific reports

authors： Coni S,Mancuso AB,Di Magno L,Sdruscia G,Manni S,Serrao SM,Rotili D,Spiombi E,Bufalieri F,Petroni M,Kusio-Kobialka M,De Smaele E,Ferretti E,Capalbo C,Mai A,Niewiadomski P,Screpanti I,Di Marcotullio L,Canettieri G

更新日期：2017-03-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Zhou Y,Sun W,Chen J,Tan H,Xiao Y,Li Q,Ji Q,Gao S,Chen L,Chen S,Zhang L,Chen W

更新日期：2020-04-24 00:00:00

abstract：:Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data ...

journal_title：Scientific reports

authors： Fukazawa T,Guo M,Ishida N,Yamatsuji T,Takaoka M,Yokota E,Haisa M,Miyake N,Ikeda T,Okui T,Takigawa N,Maeda Y,Naomoto Y

更新日期：2016-02-05 00:00:00

abstract：:Transcriptional enhancers are non-coding segments of DNA that play a central role in the spatiotemporal regulation of gene expression programs. However, systematically and precisely predicting enhancers remain a major challenge. Although existing methods have achieved some success in enhancer prediction, they still su...

journal_title：Scientific reports

authors： Liu F,Li H,Ren C,Bo X,Shu W

更新日期：2016-06-22 00:00:00

abstract：:This study demonstrates significant visible light photo-detection capability of pristine ZnO nanostructure thin films possessing substantially high percentage of oxygen vacancies [Formula: see text] and zinc interstitials [Formula: see text], introduced by simple tuning of economical solution method. The demonstrated ...

journal_title：Scientific reports

authors： Khokhra R,Bharti B,Lee HN,Kumar R

更新日期：2017-11-08 00:00:00