Abstract：
:There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide. However, the exact mechanism and potential genes implicated are still unidentified. To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link between these new regulatory RNA molecules and hepatic function in men has not been investigated. Advanced technologies of lncRNA subcellular localization and silencing were used to identify a novel intergenic Y-linked lncRNA, named lnc-KDM5D-4, and investigate its role in fatty liver-associated atherosclerosis. We found that lnc-KDM5D-4 is retained within the nucleus in hepatocytes. Its knockdown leads to changes in genes leading to increased lipid droplets formation in hepatocytes resulting in a downstream effect contributing to the chronic inflammatory process that underpin CAD. Our findings provide the first evidence for the implication of lnc-KDM5D-4 in key processes related to fatty liver and cellular inflammation associated with atherosclerosis and CAD in men.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Molina E,Chew GS,Myers SA,Clarence EM,Eales JM,Tomaszewski M,Charchar FJdoi
10.1038/s41598-017-17165-9subject
Has Abstractpub_date
2017-12-01 00:00:00pages
16710issue
1issn
2045-2322pii
10.1038/s41598-017-17165-9journal_volume
7pub_type
杂志文章abstract：:Auxetic mechanical metamaterials are engineered systems that exhibit the unusual macroscopic property of a negative Poisson's ratio due to sub-unit structure rather than chemical composition. Although their unique behaviour makes them superior to conventional materials in many practical applications, they are limited ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08395
更新日期：2015-02-11 00:00:00
abstract：:Laser-Stimulated Fluorescence (LSF) is used to identify fully fledged feathering in the hatchling enantiornithine bird specimen MPCM-LH-26189, supporting precocial nesting behavior in this extinct group. The LSF results include the detection of a long pennaceous wing feather as well as cover feathers around the body. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41423-7
更新日期：2019-03-21 00:00:00
abstract：:Diabetes mellitus (DM) exhibits a higher sensitivity to myocardial ischemia/reperfusion (I/R) injury and may compromise the effectiveness of cardioprotective interventions, including ischemic preconditioning. We previously found that liver ischemic preconditioning (RLIPC) could limit infarct size post I/R in non-diabe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81422-1
更新日期：2021-01-21 00:00:00
abstract：:In the eyeblink conditioning paradigm, cerebellar Purkinje cells learn to respond to the conditional stimulus with an adaptively timed pause in its spontaneous firing. Evidence suggests that the pause is elicited by glutamate released from parallel fibers and acting on metabotropic receptors (mGluR7) which initiates a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72581-8
更新日期：2020-09-24 00:00:00
abstract：:Rangelands play a critical role in the global carbon cycle. However, the eco-physiological mechanisms associated with the effects of grazing on leaf photosynthesis and soil respiration remain poorly understood. To examine the impacts of grazing on leaf photosynthesis and soil respiration, we measured the photosyntheti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30087
更新日期：2016-07-25 00:00:00
abstract：:There is no preclinical mouse model to investigate pulmonary Mycobacteroides abscessus (formerly Mycobacterium abscessus) infection in an immunocompetent mouse strain, especially in the context of antibiotic testing and regimen development. We developed a mouse model of pulmonary M. abscessus infection using the aeros...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60452-1
更新日期：2020-02-28 00:00:00
abstract：:Schizophrenia is one of the most prevalent psychiatric disorders with complex genetic etiology. Accumulating evidence suggests that energy metabolism and oxidative stress play important roles in the pathophysiology of schizophrenia. Dysfunction of mitochondrial respiratory chain and altered expression of complex I sub...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11076
更新日期：2015-06-08 00:00:00
abstract：:Antimicrobial stewardship programmes (ASP) are aimed at optimising antimicrobial utilization. However, only few studies have focused on paediatric intensive care units (PICU), where inappropriate antibiotic use occurs frequently. We assessed the effect and safety of a once weekly paediatric infectious disease (PID) wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65671-0
更新日期：2020-06-01 00:00:00
abstract：:Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00802-8
更新日期：2017-05-03 00:00:00
abstract：:It is generally assumed that an investment into cognitive abilities and their associated cost is particularly beneficial for long-lived species, as a prolonged lifespan allows to recoup the initial investment. However, ephemeral organisms possess astonishing cognitive abilities too. Invertebrates, for example, are cap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51652-5
更新日期：2019-10-23 00:00:00
abstract：:Acinetobacter baumannii is a common cause of health care associated infections worldwide. A. pittii is an opportunistic pathogen also frequently isolated from Acinetobacter infections other than those from A. baumannii. Knowledge of Acinetobacter virulence factors and their role in pathogenesis is scarce. Also, there ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04870-8
更新日期：2017-07-04 00:00:00
abstract：:Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controll...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01774
更新日期：2013-01-01 00:00:00
abstract：:Cardiac magnetic resonance (CMR) is becoming the imaging modality of choice in multicenter studies where highly reproducible measurements are necessary. The purpose of this study was to assess the effect of comprehensive initial training on reproducibility of quantitative left ventricular (LV) parameters estimated usi...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-48685-1
更新日期：2019-08-21 00:00:00
abstract：:We investigated whether dogs remember their spontaneous past actions relying on episodic-like memory. Dogs were trained to repeat a small set of actions upon request. Then we tested them on their ability to repeat other actions produced by themselves, including actions performed spontaneously in everyday situations. D...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67302-0
更新日期：2020-06-26 00:00:00
abstract：:Odorant binding proteins (OBPs) play critical roles in chemical communication of insects, as they recognize and transport environmental chemical signals to receptors. The diving beetle Cybister japonicus Sharp shows a remarkable sexual dimorphism. The foreleg tarsi of males are equipped with large suction cups, believ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31848
更新日期：2016-08-22 00:00:00
abstract：:The overall goal of this work was to measure the efficacy of fMRI for predicting whether a dog would be a successful service dog. The training and imaging were performed in 49 dogs entering service training at 17-21 months of age. 33 dogs completed service training and were matched with a person, while 10 were release...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43704
更新日期：2017-03-07 00:00:00
abstract：:Mitochondria are key cellular signaling platforms, affecting fundamental processes such as cell proliferation, differentiation and death. However, it remains unclear how mitochondrial signaling affects other organelles, particularly lysosomes. Here, we demonstrate that mitochondrial respiratory chain (RC) impairments ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45076
更新日期：2017-03-27 00:00:00
abstract：:Routine antimicrobial susceptibility testing (AST) can prevent deaths due to bacteria and reduce the spread of multi-drug-resistance, but cannot be regularly performed in resource-limited-settings due to technological challenges, high-costs, and lack of trained professionals. We demonstrate an automated and cost-effec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39203
更新日期：2016-12-15 00:00:00
abstract：:We investigated the association between impulsivity related traits and BMI at the observational and genetic epidemiology level in a cross-sectional population of healthy young American-European adults. We studied 998 students and university staff of European ancestry recruited from Chicago (Illinois) and Athens (Georg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53922-8
更新日期：2019-11-26 00:00:00
abstract：:Increased interest in poly(ethylene terephthalate) (PET)-degrading enzymes (PETases) have generated efforts to find mutants with improved catalytic activity and thermostability. Here, we present a simple and fast method to determine relative enzyme kinetics through bulk absorbance measurements of released products ove...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79031-5
更新日期：2021-01-13 00:00:00
abstract：:CLE peptide hormones are critical regulators of many cell proliferation and differentiation mechanisms in plants. These 12-13 amino acid glycosylated peptides play vital roles in a diverse range of plant tissues, including the shoot, root and vasculature. CLE peptides are also involved in controlling legume nodulation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09296-w
更新日期：2017-08-24 00:00:00
abstract：:Interfacial charge transfer from photoexcited ruthenium-based N3 dye molecules into ZnO thin films received controversial interpretations. To identify the physical origin for the delayed electron transfer in ZnO compared to TiO2, we probe directly the electronic structure at both dye-semiconductor interfaces by applyi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24422
更新日期：2016-04-13 00:00:00
abstract：:The 170 National Forests and Grasslands (NFs) in the conterminous United States are public lands that provide important ecosystem services such as clean water and timber supply to the American people. This study investigates the potential impacts of climate change on two key ecosystem functions (i.e., water yield and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24441
更新日期：2016-04-21 00:00:00
abstract：:Members of the diffusible signal factor (DSF) family are a novel class of quorum sensing (QS) signals in diverse Gram-negative bacteria. Although previous studies have identified RpfF as a key enzyme for the biosynthesis of DSF family signals, many questions in their biosynthesis remain to be addressed. In this study ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13294
更新日期：2015-08-20 00:00:00
abstract：:The low-temperature heat capacity of (U1-yThy)O2 and 238Pu-doped UO2 samples were determined using hybrid adiabatic relaxation calorimetry. Results of the investigated systems revealed the presence of the magnetic transition specific for UO2 in all three intermediate compositions of the uranium-thorium dioxide (y = 0....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51476-3
更新日期：2019-10-21 00:00:00
abstract：:The purpose of the present study was to assess the differential intraocular pressure response (IOP) to dexamethasone (DEX) treatment at two dose levels (100 or 500 nM) in perfusion cultured Indian cadaveric eyes to investigate glucocorticoid (GC) responsiveness. In a human organ-cultured anterior segment (HOCAS) set-u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80112-8
更新日期：2021-01-12 00:00:00
abstract：:In Duchenne muscular dystrophy, progressive loss of muscle tissue is accompanied by fibrosis, chronic inflammation and reduced muscle regenerative capacity. Although much is known about the development of fibrosis and chronic inflammation in muscular dystrophy, less is known about how they are mechanistically linked t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24708
更新日期：2016-05-31 00:00:00
abstract：:A novel and facile two-step strategy has been designed to prepare high performance bi-transition-metals (Fe- and Mo-) carbide supported on nitrogen-doped graphene (FeMo-NG) as electrocatalysts for oxygen reduction reactions (ORR). The as-synthesized FeMo carbide -NG catalysts exhibit excellent electrocatalytic activit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10389
更新日期：2015-05-22 00:00:00
abstract：:Photoreceptor degeneration due to retinitis pigmentosa (RP) is a primary cause of inherited retinal blindness. Photoreceptor cell-replacement may hold the potential for repair in a completely degenerate retina by reinstating light sensitive cells to form connections that relay information to downstream retinal layers....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29784
更新日期：2016-07-13 00:00:00
abstract：:The brain-derived neurotrophic factor BDNF plays a critical role in neuronal development and the induction of L-LTP at glutamatergic synapses in several brain regions. However, the cellular and molecular mechanisms underlying these BDNF effects have not been firmly established. Using in vitro cultures of cortical neur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14778
更新日期：2015-10-06 00:00:00
