Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice.

Abstract:

:Externally manipulating memories by presenting conditioned stimuli (CS) during sleep is a new approach to investigating memory processing during sleep. However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated. In this study, mice underwent trace fear conditioning consisting of an auditory CS paired with a foot shock, and the auditory CS was re-presented during subsequent REM or NREM sleep. Mice that received auditory cueing during NREM but not REM sleep showed impaired fear memory upon later presentation of the auditory CS. These findings have implications for the use of cueing during sleep and advance our understanding of the role of REM and NREM sleep in memory consolidation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Purple RJ,Sakurai T,Sakaguchi M

doi

10.1038/srep46247

subject

Has Abstract

pub_date

2017-04-12 00:00:00

pages

46247

issn

2045-2322

pii

srep46247

journal_volume

7

pub_type

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