Abstract:
:Externally manipulating memories by presenting conditioned stimuli (CS) during sleep is a new approach to investigating memory processing during sleep. However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated. In this study, mice underwent trace fear conditioning consisting of an auditory CS paired with a foot shock, and the auditory CS was re-presented during subsequent REM or NREM sleep. Mice that received auditory cueing during NREM but not REM sleep showed impaired fear memory upon later presentation of the auditory CS. These findings have implications for the use of cueing during sleep and advance our understanding of the role of REM and NREM sleep in memory consolidation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Purple RJ,Sakurai T,Sakaguchi Mdoi
10.1038/srep46247subject
Has Abstractpub_date
2017-04-12 00:00:00pages
46247issn
2045-2322pii
srep46247journal_volume
7pub_type
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