Abstract:
:Subcutaneous white adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating whole body metabolism. Skin exposure to UV wavelengths from sunlight is required for Vitamin D synthesis and pigmentation, although it is plausible that longer visible wavelengths that penetrate the skin may regulate scWAT function. In this regard, we discovered a novel blue light-sensitive current in human scWAT that is mediated by melanopsin coupled to transient receptor potential canonical cation channels. This pathway is activated at physiological intensities of light that penetrate the skin on a sunny day. Daily exposure of differentiated adipocytes to blue light resulted in decreased lipid droplet size, increased basal lipolytic rate and alterations in adiponectin and leptin secretion. Our results suggest that scWAT function may be directly under the influence of ambient sunlight exposure and may have important implications for our current understanding of adipocyte biology. (150 words).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ondrusova K,Fatehi M,Barr A,Czarnecka Z,Long W,Suzuki K,Campbell S,Philippaert K,Hubert M,Tredget E,Kwan P,Touret N,Wabitsch M,Lee KY,Light PEdoi
10.1038/s41598-017-16689-4subject
Has Abstractpub_date
2017-11-27 00:00:00pages
16332issue
1issn
2045-2322pii
10.1038/s41598-017-16689-4journal_volume
7pub_type
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