Abstract:
:Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg). ASS1 is silenced in many human malignancies therefore, these tumors require extracellular Arg for growth. The Arg-degrading recombinant protein, pegylated arginine deiminase (ADI-PEG20), has been in clinical trials for targeting Arg auxotrophic tumors by Arg starvation therapy. Resistance to Arg starvation is often developed through reactivation of ASS1 expression. We previously demonstrated that ASS1 silencing is controlled by HIF-1α and Arg starvation-reactivated ASS1 is associated with HIF-1α downregulation. However, mechanisms underlying ASS1 repression and HIF-1α turnover are not known. Here, we demonstrate that interplay of p300-HDAC2-Sin3A in the chromatin remodeling system is involved in HIF-1α degradation at the ASS1 promoter. The histone acetyltransferase p300 is normally associated with the ASS1 promoter to maintain acetylated H3K14ac and H3K27ac for ASS1 silencing. Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1α-proteasomal complex, driven by PHD2, to degrade HIF-1α in situ. Arg starvation induces PHD2 and HDAC2 interaction which is sensitive to antioxidants. This is the first report describing epigenetic regulation of chromosomal HIF-1α turnover in gene activation that bears important implication in cancer therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tsai WB,Long Y,Chang JT,Savaraj N,Feun LG,Jung M,Chen HHW,Kuo MTdoi
10.1038/s41598-017-11445-0subject
Has Abstractpub_date
2017-09-07 00:00:00pages
10814issue
1issn
2045-2322pii
10.1038/s41598-017-11445-0journal_volume
7pub_type
杂志文章abstract::To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed over 4-weeks that resulted in steatosis. Here we show time-of-day specific changes in expression of clock genes and clock-controlled genes, including those associa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03725
更新日期:2014-01-16 00:00:00
abstract::During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01284
更新日期:2013-01-01 00:00:00
abstract::Weathered granite of ion-adsorption rare earth elements (REEs) ore collected at Jiangxi Province, China was investigated to identify the minerals abundant in REEs. The analyses of scanning electron microscopy (SEM)-energy dispersive spectrometry (EDS) and laser ablation inductively coupled plasma mass spectrometry (LA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76981-8
更新日期:2020-11-19 00:00:00
abstract::Purpose Global sagittal imbalance with lumbar hypo-lordosis leads to various problems in elderly populations and is often treated with long-segment fusion and osteotomy. These highly invasive procedures result in a wide range of rigid spines with a high rate of complications. Although some reports have mentioned the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63648-7
更新日期:2020-04-21 00:00:00
abstract::Kidney regeneration from pluripotent stem cells is receiving a lot of attention because limited treatments are currently available for chronic kidney disease (CKD). It has been shown that uremic state in CKD is toxic to somatic stem/progenitor cells, such as endothelial progenitor and mesenchymal stem cells, affecting...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33256-7
更新日期:2018-10-08 00:00:00
abstract::A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in isc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38161
更新日期:2016-12-02 00:00:00
abstract::This study described the results of environmental enterovirus surveillance conducted in Shandong Province of China in 2013. Altogether 39 sewage samples were collected and 873 enterovirus isolates (including 334 polioviruses) belonging to 22 serotypes were obtained. Echovirus (E) -7, coxsackievirus (CV) -B5, E-11, E-6...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31474
更新日期:2016-08-11 00:00:00
abstract::We report a method to promote photoluminescence emission in graphene materials by enhancing carrier scattering instead of directly modifying band structure in multilayer reduced graphene oxide (rGO) nanospheres. We intentionally curl graphene layers to form nanospheres by reducing graphene oxide with spherical polymer...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02315
更新日期:2013-01-01 00:00:00
abstract::The northern microrefugia that existed during the Last Glacial Maximum (LGM) are a key factor in the demographic history of species. Pinus koraiensis has a unique distribution in northeast Asia. The Changbai Mountains and the Korean peninsula (CM/KP) are usually considered to be the LGM refugia for P. koraiensis. Howe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18608
更新日期:2015-12-22 00:00:00
abstract::Understanding the transmission patterns of African swine fever (ASF) among wild boar (Sus scrofa) is an issue of major interest, especially in the wake of the current ASF epidemic. Given the high stability of ASF-virus, there is concern about scavengers spreading infectious carcass material in the environment. Here, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47623-5
更新日期:2019-08-07 00:00:00
abstract::Mulching with organic materials is a management practice with long history for weed suppression, soil water conservation and erosion control. Its potential impact on crop pests is less well explored. Here we report its utility for reducing crop damage by the serious pest, sweetpotato weevil (Cylas formicarius). Labora...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50521-5
更新日期:2019-10-16 00:00:00
abstract::Aurantiochytrium is a promising docosahexaenoic acid (DHA) production candidate due to its fast growth rate and high proportions of lipid and DHA content. In this study, high-throughput RNA sequencing technology was employed to explore the acclimatization of this DHA producer under cold stress at the transcriptional l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14446
更新日期:2015-09-25 00:00:00
abstract::Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02843-5
更新日期:2017-06-02 00:00:00
abstract::Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56571-z
更新日期:2020-01-08 00:00:00
abstract::Metamaterial absorbers can provide good solutions for radar-cross-section (RCS) reduction. In spite of their attractive features of thinness, lightness, and low cost, resonant metamaterial absorbers have a drawback of narrow bandwidth. For practical radar applications, wideband absorbers are necessary. In this paper, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31823
更新日期:2016-08-22 00:00:00
abstract::Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and their involvement in disease progression. A new ultra performance chromatography mass spectrometry (UPLC-MS/MS) method was developed to q...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42535-w
更新日期:2019-04-16 00:00:00
abstract::The real time detection of quantitative oxygen release from the cathode is performed by in-situ Gas Chromatography as a tool to not only determine the amount of oxygen release from a lithium-ion cell but also to address the safety concerns. This in-situ gas chromatography technique monitoring the gas evolution during ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23394
更新日期:2016-03-22 00:00:00
abstract::Infection of humans with Chlamydia trachomatis, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54886-5
更新日期:2019-12-04 00:00:00
abstract::The discovery of resistance switching memristors marks a paradigm shift in the search for alternative non-volatile memory components in the semiconductor industry. Normally a dielectric in these bistable memory cells changes its resistance with an applied electric field or current, albeit retaining the resistive state...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20598-5
更新日期:2018-02-01 00:00:00
abstract::Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with N...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-019-51522-0
更新日期:2019-10-18 00:00:00
abstract::NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas. This study investigates for the first time the role of NANOG expression in early stages of laryngeal tumourigenesis and its potential utility as cancer r...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-017-11709-9
更新日期:2017-09-11 00:00:00
abstract::Organic thin-film transistors for high frequency applications require large transconductances in combination with minimal parasitic capacitances. Techniques aiming at eliminating parasitic capacitances are prone to produce a mismatch between electrodes, in particular gaps between the gate and the interlayer electrodes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31387
更新日期:2016-09-27 00:00:00
abstract::Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22483-7
更新日期:2018-03-16 00:00:00
abstract::If the components of a battery, including electrodes, separator, electrolyte and the current collectors can be designed as paints and applied sequentially to build a complete battery, on any arbitrary surface, it would have significant impact on the design, implementation and integration of energy storage devices. Her...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00481
更新日期:2012-01-01 00:00:00
abstract::Novel amorphous iron hydrides (AIHs) are synthesized for the first time under ambient conditions by employing novel "quiescent reaction", without stirring for mixing solutions, during a conventional aqueous reduction-precipitation process. The kind and morphology of AIHs are dependent on the processing condition, wher...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63124-2
更新日期:2020-04-10 00:00:00
abstract::A central goal of electronics based on correlated materials or 'Mottronics' is the ability to switch between distinct collective states with a control voltage. Small changes in structure and charge density near a transition can tip the balance between competing phases, leading to dramatic changes in electronic and mag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01876
更新日期:2013-01-01 00:00:00
abstract::Translesion synthesis (TLS) is the mechanism by which DNA polymerases replicate through unrepaired DNA lesions. TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites. Pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15759
更新日期:2015-10-27 00:00:00
abstract::Aberrant methylated genes (DMGs) play an important role in the etiology and pathogenesis of esophageal squamous cell carcinoma (ESCC). In this study, we aimed to integrate three cohorts profile datasets to ascertain aberrant methylated-differentially expressed genes and pathways associated with ESCC by comprehensive b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66847-4
更新日期:2020-06-16 00:00:00
abstract::Our data about pathogenesis of hepatic steatosis after liver transplantation is scarce. This study aimed to investigate the association between serum adipokines and insulin resistance with hepatic steatosis in liver transplant recipients. We investigated the association between insulin resistance, serum adiponectin, i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69571-1
更新日期:2020-07-29 00:00:00
abstract::The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain. But in some experimental conditions (e.g., memory ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30743
更新日期:2016-08-04 00:00:00