Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration.

abstract：:The patterns of life exhibited by large populations have been described and modeled both as a basic science exercise and for a range of applied goals such as reducing automotive congestion, improving disaster response, and even predicting the location of individuals. However, these studies have had limited access to c...

journal_title：Scientific reports

authors： Frank MR,Mitchell L,Dodds PS,Danforth CM

更新日期：2013-01-01 00:00:00

abstract：:Infantile spasms (ISs) is a devastating form of an early infantile epileptic encephalopathy. The patterns of response of multiple regimens, and the difference in response rates for the cases who receive first-line therapies on time versus those who receive them after non-first-line therapies are unknown. We performed ...

journal_title：Scientific reports

authors： Mao L,Kessi M,Peng P,He F,Zhang C,Yang L,Wu L,Yin F,Peng J

更新日期：2020-07-13 00:00:00

abstract：:One of the challenges that plasma research encounters is how to generate a large-scale plasma plume at atmospheric pressure. Through utilizing a third electrode biased by a direct-current voltage, a longer plasma plume is generated by a plasma jet in dielectric barrier discharge configurations. Results indicate that t...

journal_title：Scientific reports

authors： Li X,Li Y,Zhang P,Jia P,Dong L

更新日期：2016-10-19 00:00:00

abstract：:Cell therapy using intramuscular injections of autologous bone-marrow mononuclear cells (BM-MNCs) improves clinical symptoms and can prevent limb amputation in atherosclerotic peripheral arterial disease (PAD) patients with critical limb ischemia (CLI). The purpose of this study was to evaluate the effects of the numb...

journal_title：Scientific reports

authors： Yusoff FM,Kajikawa M,Takaeko Y,Kishimoto S,Hashimoto H,Maruhashi T,Nakashima A,Wahid SFSA,Higashi Y

更新日期：2020-11-16 00:00:00

abstract：:Affinity measure is a key factor that determines the quality of the analysis of a complex network. Here, we introduce a type of statistics, activation forces, to weight the links of a complex network and thereby develop a desired affinity measure. We show that the approach is superior in facilitating the analysis thro...

journal_title：Scientific reports

authors： Guo J,Guo H,Wang Z

更新日期：2011-01-01 00:00:00

abstract：:Lower respiratory infections, such as community-acquired pneumonia (CAP), and chronic obstructive pulmonary disease (COPD) rank among the most frequent causes of death worldwide. Improved diagnostics and profound pathophysiological insights are urgent clinical needs. In our cohort, we analysed transcriptional networks...

journal_title：Scientific reports

authors： Bertrams W,Griss K,Han M,Seidel K,Klemmer A,Sittka-Stark A,Hippenstiel S,Suttorp N,Finkernagel F,Wilhelm J,Greulich T,Vogelmeier CF,Vera J,Schmeck B

更新日期：2020-01-14 00:00:00

abstract：:Myopia is the commonest eye disorder in the world. High myopes are predisposed to ocular pathologies. The vasoactive intestinal peptide receptor 2 (VIPR2) gene was identified as a myopia susceptibility locus by our group and another group. We continued to fine-map this locus. A case-control study was performed in 4 se...

journal_title：Scientific reports

authors： Leung KH,Luo S,Kwarteng R,Chen SG,Yap MKH,Huang CL,Yip SP

更新日期：2019-12-03 00:00:00

abstract：:To explore a simple and easy-to-learn procedure for the isolation of human quiescent hepatic stellate cells (HSCs) that requires no advanced training. Thus reducing costs and increasing efficiency. This protocol will provide sufficient primary cells with minimal contaminants for future basic research on diseases assoc...

journal_title：Scientific reports

authors： Zhai X,Wang W,Dou D,Ma Y,Gang D,Jiang Z,Shi B,Jin B

更新日期：2019-09-04 00:00:00

abstract：:Ensuring lumpfish health and welfare in salmon farms is vital to reduce the high mortality rates reported and to guarantee a high delousing efficiency. Recent observations of farmed lumpfish livers have shown colours ranging from pale (colours 1 and 2), through bright orange (colours 3 and 4), to dark reddish-brown (c...

journal_title：Scientific reports

authors： Eliasen K,Patursson EJ,McAdam BJ,Pino E,Morro B,Betancor M,Baily J,Rey S

更新日期：2020-06-02 00:00:00

abstract：:Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and their involvement in disease progression. A new ultra performance chromatography mass spectrometry (UPLC-MS/MS) method was developed to q...

journal_title：Scientific reports

authors： D'Andrea G,Pizzolato G,Gucciardi A,Stocchero M,Giordano G,Baraldi E,Leon A

更新日期：2019-04-16 00:00:00

abstract：:Low-dimensional behavior of large systems of globally coupled oscillators has been intensively investigated since the introduction of the Ott-Antonsen ansatz. In this report, we generalize the Ott-Antonsen ansatz to second-order Kuramoto models in complex networks. With an additional inertia term, we find a low-dimens...

journal_title：Scientific reports

authors： Ji P,Peron TK,Rodrigues FA,Kurths J

更新日期：2014-05-02 00:00:00

abstract：:Tumor cells tend to behave differently in response to immune selective conditions. Contrary to those in therapeutic antitumor conditions, tumor cells in prophylactic antitumor conditions lose antigen expression for antitumor immune escape. Here, using a CT26/HER2 tumor model, we investigate the underlying mechanism(s)...

journal_title：Scientific reports

authors： Han BS,Ji S,Woo S,Lee JH,Sin JI

更新日期：2019-02-27 00:00:00

abstract：:Decadal climate predictability in the South Atlantic is explored by performing reforecast experiments using a coupled general circulation model with two initialization schemes; one is assimilated with observed sea surface temperature (SST) only, and the other is additionally assimilated with observed subsurface ocean ...

journal_title：Scientific reports

authors： Morioka Y,Doi T,Storto A,Masina S,Behera SK

更新日期：2018-06-04 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood. The aim of this study is to investigate the metabolic changes in DMD u...

journal_title：Scientific reports

authors： Dabaj I,Ferey J,Marguet F,Gilard V,Basset C,Bahri Y,Brehin AC,Vanhulle C,Leturcq F,Marret S,Laquerrière A,Schmitz-Afonso I,Afonso C,Bekri S,Tebani A

更新日期：2021-01-21 00:00:00

abstract：:LMNA gene encodes lamins A and C, two major components of the nuclear lamina, a network of intermediate filaments underlying the inner nuclear membrane. Most of LMNA mutations are associated with cardiac and/or skeletal muscles defects. Muscle laminopathies include Emery-Dreifuss Muscular Dystrophy, Limb-Girdle Muscul...

journal_title：Scientific reports

authors： Janin A,Bauer D,Ratti F,Valla C,Bertrand A,Christin E,Chopin E,Streichenberger N,Bonne G,Gache V,Cohen T,Méjat A

更新日期：2018-04-04 00:00:00

abstract：:The analysis of DNA methylation at CpG dinucleotides has become a major research focus due to its regulatory role in numerous biological processes, but the requisite need for assays which amplify bisulfite-converted DNA represents a major bottleneck due to the unique design constraints imposed on bisulfite-PCR primers...

journal_title：Scientific reports

authors： Lu J,Johnston A,Berichon P,Ru KL,Korbie D,Trau M

更新日期：2017-01-24 00:00:00

abstract：:Consistent cell preparation is a fundamental preliminary step for understanding complex cellular mechanisms in various cell-based research fields, including basic cell biology, cancer research, and tissue engineering. However, certain elusive factors, such as cellular de-differentiation and contamination with mycoplas...

journal_title：Scientific reports

authors： Osaki T,Kageyama T,Shimazu Y,Mysnikova D,Takahashi S,Takimoto S,Fukuda J

更新日期：2017-05-15 00:00:00

abstract：:The knowledge of the metallization of warm dense helium has important implications for understanding the thermal histories, stellar structure and magnetic field environment of giant planets. However, it is also a pendent scientific topic. For a revisiting into the properties of warm dense helium, we performed extensiv...

journal_title：Scientific reports

authors： Zhang W,Li Z,Fu Z,Dai J,Chen Q,Cai L

更新日期：2017-02-03 00:00:00

abstract：:The effect of substrate surface roughening on the capacitance of Ni(OH)2/NiOOH nanowall array samples produced via chemical bath deposition for 2, 4, 6, 24 and 48 h on an as-received stainless steel substrate and the same substrate after sandblasting has been investigated. Symmetric cells were subjected to 120,000 cha...

journal_title：Scientific reports

authors： Pimsawat A,Tangtrakarn A,Pimsawat N,Daengsakul S

更新日期：2019-11-14 00:00:00

abstract：:The Paraná delta, growing at a rate of c. 2 km(2) yr(-1) since 6,000 yrs, is one of the most complete records of the Late Holocene in southern South America. The evolution of this 17,400 km(2) delta enclosed in Plata estuary, can be tracked by a series of 343 successive coastal-ridges showing a c.11 years period, in c...

journal_title：Scientific reports

authors： Milana JP,Kröhling D

更新日期：2015-08-06 00:00:00

abstract：:Cancer vaccines are less effective at old than at young age because of immunosenescence. Besides, in preliminary observations we showed that the immunization with HER-2/neu DNA plasmid in transgenic young mice (standard immunization, SI) delays but not abrogate spontaneous mammary tumours progressively appearing durin...

journal_title：Scientific reports

authors： Provinciali M,Barucca A,Orlando F,Pierpaoli E

更新日期：2017-06-08 00:00:00

abstract：:Liquid biopsy can provide a strong basis for precision medicine. We aimed to identify novel single-nucleotide variants (SNVs) in circulating tumor DNA (ctDNA) in patients with hepatocellular carcinoma (HCC). Deep sequencing of plasma-derived ctDNA from 59 patients with HCC was performed using a panel of 2924 SNVs in 6...

journal_title：Scientific reports

authors： Kim SS,Eun JW,Choi JH,Woo HG,Cho HJ,Ahn HR,Suh CW,Baek GO,Cho SW,Cheong JY

更新日期：2020-10-20 00:00:00

abstract：:The rapid increase in use of electronic-cigarettes (e-cigarettes), especially among youth, raises the urgency for regulating bodies to make informed decisions, guidance, and policy on these products. This study evaluated cardiac function in an experimental model following exposure to e-cigarettes. We subjected C57BL/6...

journal_title：Scientific reports

authors： Shi H,Fan X,Horton A,Haller ST,Kennedy DJ,Schiefer IT,Dworkin L,Cooper CJ,Tian J

更新日期：2019-03-11 00:00:00

abstract：:The lack of a precisely-dated, unequivocal climate proxy from northern China, where precipitation variability is traditionally considered as an East Asian summer monsoon (EASM) indicator, impedes our understanding of the behaviour and dynamics of the EASM. Here we present a well-dated, pollen-based, ~20-yr-resolution ...

journal_title：Scientific reports

authors： Chen F,Xu Q,Chen J,Birks HJ,Liu J,Zhang S,Jin L,An C,Telford RJ,Cao X,Wang Z,Zhang X,Selvaraj K,Lu H,Li Y,Zheng Z,Wang H,Zhou A,Dong G,Zhang J,Huang X,Bloemendal J,Rao Z

更新日期：2015-06-18 00:00:00

abstract：:Recently, 5-hydroxymethylcytosine patterning across the tumor genome was considered as a hallmark of cancer development and progression. However, locus-specific difference of hydroxymethylation between colorectal cancer and normal tissue is unknown. In this study, we performed a newly developed method, HMST-seq, to pr...

journal_title：Scientific reports

authors： Li M,Gao F,Xia Y,Tang Y,Zhao W,Jin C,Luo H,Wang J,Li Q,Wang Y

更新日期：2016-08-22 00:00:00

abstract：:Brønsted-Lewis acidic ionic liquids (ILs) were applied to catalyze cellobiose to prepare levulinic acid (LA) in one pot under hydrothermal conditions. Under the optimum conditions, the highest LA yield of 67.51% was obtained when low [HO3S-(CH2)3-mim]Cl-FeCl3 (molar fraction of FeCl3 x = 0.60) was used. This indicated...

journal_title：Scientific reports

authors： Liu S,Wang K,Yu H,Li B,Yu S

更新日期：2019-02-12 00:00:00

abstract：:Ultracentrifugationon sucrose density gradientappears to be the best purification protocol for extracellular vesicle (EVs) purification. After this step, to reduce disulfide bridges linking exogenous proteins to the vesicles, the collected samples are routinely washed and treated with dithiothreitol (DTT). Such incuba...

journal_title：Scientific reports

authors： Santucci L,Bruschi M,Del Zotto G,Antonini F,Ghiggeri GM,Panfoli I,Candiano G

更新日期：2019-09-10 00:00:00

abstract：:Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear. We therefore characterized the skeletal muscle proteome following exercise traini...

journal_title：Scientific reports

authors： Kleinert M,Parker BL,Jensen TE,Raun SH,Pham P,Han X,James DE,Richter EA,Sylow L

更新日期：2018-07-16 00:00:00

abstract：:Dendritic cell (DC)-derived exosomes (Dexo) contain the machinery necessary to activate potent antigen-specific immune responses. As promising cell-free immunogens, Dexo have been tested in previous clinical trials for cancer vaccine immunotherapy, yet resulted in limited therapeutic benefit. Here, we explore a novel ...

journal_title：Scientific reports

authors： Damo M,Wilson DS,Simeoni E,Hubbell JA

更新日期：2015-12-03 00:00:00

abstract：:Epilepsy is one of the most common neurological disorders and the administration of antiepileptic drugs (AEDs) is the most common treatment. Although there are more than 15 AEDs available, a third of epilepsy patients remain refractory to available drugs, so novel effective drugs are needed. Here, we found that DV21, ...

journal_title：Scientific reports

authors： Xu M,Sun P,Zhang Y,Yang CH,Wei X,Ma XX,Yang CR,Ni KM,Zhang YJ,Li XM

更新日期：2017-05-10 00:00:00