Abstract：
:Recently, 5-hydroxymethylcytosine patterning across the tumor genome was considered as a hallmark of cancer development and progression. However, locus-specific difference of hydroxymethylation between colorectal cancer and normal tissue is unknown. In this study, we performed a newly developed method, HMST-seq, to profile 726 aberrant methylated loci and 689 aberrant hydroxymethylated loci synchronously in genome wide of colorectal cancers, majority of which presented higher methylation or lower hydroxymethylationin than in normal group. Besides, abnormal hydroxymethylated modification was more frequently occur at proximal regions close to TSSs and TSSs regions than abnormal methylation. Subsequently, we screened four genes (ALOX15, GHRHR, TFPI2 and TKTL1) with aberrant methylation and aberrant hydroxymethylation at some genome position by functional enrichment analysis as candidate genes associated with colorectal cancer. Our results may allow us to select differentially epigenetically modified target genes implicated in colorectal cancer tumorigenesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li M,Gao F,Xia Y,Tang Y,Zhao W,Jin C,Luo H,Wang J,Li Q,Wang Ydoi
10.1038/srep31826subject
Has Abstractpub_date
2016-08-22 00:00:00pages
31826issn
2045-2322pii
srep31826journal_volume
6pub_type
杂志文章abstract：:Despite the fact that 2015 was the international year of light, no mention was made of the fact that radiation contains entropy as well as energy, with different spectral distributions. Whereas the energy function has been vastly studied, the radiation entropy distribution has not been analysed at the same speed. The ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01622-6
更新日期：2017-05-10 00:00:00
abstract：:We demonstrate a self-cleanable, waterproof, highly transparent, and flexible Ag network covered by a very thin transparent polytetrafluoroethylene (PTFE) layer using typical magnetron sputtering for multi-functional flexible thin film heaters used in smart windows. By passivation of the self-assembled Ag network with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53243-w
更新日期：2019-11-13 00:00:00
abstract：:Pristine and functionalized multi-walled carbon nanotubes (MWCNTs) were investigated as adsorbent materials inside solid-phase extraction (SPE) cartridges for extraction and preconcentration of 8 EU-relevant organic micropollutants (with different pKa and polarity) before chromatographic analysis of surface water. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79244-8
更新日期：2020-12-18 00:00:00
abstract：:Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72456-y
更新日期：2020-10-05 00:00:00
abstract：:We report command electro-optical switching on photolithographically-patterned graphene into a high-density electrode pattern for a high-transmission in-plane-switching (IPS) liquid crystal device. A highly-effective liquid crystal photoalignment method is used to maximize the field-driven optical contrast of a protot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11903-9
更新日期：2017-09-18 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2020-05-18 00:00:00
abstract：:Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men. Relatively little is known about the concurrence of oral and genital infection among healthy individuals. Oral and genital swab exfoliated cells were collected s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15637
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-11-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55860-x
更新日期：2019-12-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-04-17 00:00:00
abstract：:To investigate the safety, cost-effectiveness, and clinical outcomes of simultaneous bilateral total knee arthroplasty (TKA) in hemophilic arthropathy (HA), the requirements for transfusions, complications, costs, hospital stays, Hospital for Special Surgery (HSS) knee scores, knee range of motion (ROM) and revision r...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-01-25 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2020-03-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31094-1
更新日期：2018-08-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12831-4
更新日期：2017-09-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59916-1
更新日期：2020-02-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23214-8
更新日期：2018-03-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04175-w
更新日期：2017-06-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14374
更新日期：2015-09-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32343-z
更新日期：2018-09-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-09-07 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-12 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18163-7
更新日期：2017-12-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31638
更新日期：2016-08-17 00:00:00
abstract：:A low-cost compact planar leaky-wave antenna (LWA) is proposed offering directive broadside radiation over a significantly wide bandwidth. The design is based on an annular metallic strip grating (MSG) configuration, placed on top of a dual-layer grounded dielectric substrate. This defines a new two-layer parallel-pla...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-12-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12143
更新日期：2015-07-20 00:00:00
abstract：:Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This study aimed to evaluate the clinical safety and efficacy of ablating different types of fibroids, classified b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11486-5
更新日期：2017-09-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41926
更新日期：2017-02-06 00:00:00
abstract：:Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40026
更新日期：2017-01-05 00:00:00
abstract：:Habitat fragmentation can reduce population viability, especially for area-sensitive species. The Minimum Area Requirements (MAR) of a population is the area required for the population's long-term persistence. In this study, the response of occupancy probability of giant pandas against habitat patch size was studied ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37715
更新日期：2016-12-08 00:00:00
