当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways.

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways.

Abstract：

:The pathophysiological actions of fatty acids (FAs) on Alzheimer's disease (AD), which are possibly mediated by genomic effects, are widely known; however, their non-genomic actions remain elusive. The aim of this study was to investigate the non-genomic mechanism of extra-cellular palmitic acid (PA) regulating beta-amyloid peptide (Aβ) production, which may provide a link between obesity and the occurrence of AD. In an obese mouse model, a high-fat diet (HFD) significantly increased the expression levels of APP and BACE1 as well as the AD pathology in the mouse brain. We further found that PA conjugated with bovine serum albumin (PA-BSA) increased the expression of APP and BACE1 and the production of Aβ through the G protein-coupled receptor 40 (GPR40) in SK-N-MC cells. PA-BSA coupling with GPR40 significantly induced Akt activation which is required for mTOR/p70S6K1-mediated HIF-1α expression and NF-κB phosphorylation facilitating the transcriptional activity of the APP and BACE1 genes. In addition, silencing of APP and BACE1 expression significantly decreased the production of Aβ in SK-N-MC cells treated with PA-BSA. In conclusion, these results show that extra-cellular PA coupled with GPR40 induces the expression of APP and BACE1 to facilitate Aβ production via the Akt-mTOR-HIF-1α and Akt-NF-κB pathways in SK-N-MC cells.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kim JY,Lee HJ,Lee SJ,Jung YH,Yoo DY,Hwang IK,Seong JK,Ryu JM,Han HJ

doi

10.1038/s41598-017-04175-w

subject

Has Abstract

pub_date

2017-06-28 00:00:00

pages

4335

issue

1

issn

2045-2322

pii

10.1038/s41598-017-04175-w

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Cost-Effective and Highly Photoresponsive Nanophosphor-P3HT Photoconductive Nanocomposite for Near-Infrared Detection.

    abstract：:The advent of flexible optoelectronic devices has accelerated the development of semiconducting polymeric materials. We seek to replace conventional expensive semiconducting photodetector materials with our cost-effective composite system. We demonstrate in this work the successful fabrication of a photoconductive com...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16761

    authors： Tong Y,Zhao X,Tan MC,Zhao R

    更新日期：2015-11-16 00:00:00

  • Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy.

    abstract：:Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organelles. We recently demonstrated that exercise activates autophagy and re-establishe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30365-1

    authors： Campos JC,Baehr LM,Gomes KMS,Bechara LRG,Voltarelli VA,Bozi LHM,Ribeiro MAC,Ferreira ND,Moreira JBN,Brum PC,Bodine SC,Ferreira JCB

    更新日期：2018-08-07 00:00:00

  • Universal elastic-hardening-driven mechanical instability in α-quartz and quartz homeotypes under pressure.

    abstract：:As a fundamental property of pressure-induced amorphization (PIA) in ice and ice-like materials (notably α-quartz), the occurrence of mechanical instability can be related to violation of Born criteria for elasticity. The most outstanding elastic feature of α-quartz before PIA has been experimentally reported to be th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10810

    authors： Dong J,Zhu H,Chen D

    更新日期：2015-06-23 00:00:00

  • Differential proteomics profiling of the ova between healthy and Rice stripe virus-infected female insects of Laodelphax striatellus.

    abstract：:Rice stripe virus-infected females of the small brown planthopper (SBPH, Laodelphax striatellus) usually lay fewer eggs with a longer hatch period, low hatchability, malformation and retarded or defective development compared with healthy females. To explore the molecular mechanism of those phenomena, we analyzed the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27216

    authors： Liu B,Qin F,Liu W,Wang X

    更新日期：2016-06-09 00:00:00

  • Prevalence and associated factors of cataract and cataract-related blindness in the Russian Ural Eye and Medical Study.

    abstract：:To assess the prevalence of cataract and cataract surgery in a population from Russia, we conducted the population-based Ural Eye and Medical Study with 5899 participants (80.5% out of 7328 eligible individuals), with an age of 40 + years as the eligibility criterion. In the phakic population, the prevalence of nuclea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75313-0

    authors： Bikbov MM,Kazakbaeva GM,Gilmanshin TR,Zainullin RM,Nuriev IF,Zaynetdinov AF,Israfilova GZ,Panda-Jonas S,Arslangareeva II,Rakhimova EM,Rusakova IA,Jonas JB

    更新日期：2020-10-23 00:00:00

  • Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

    abstract：:Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfoli...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50065-8

    authors： Wu Y,Chang YM,Stell AJ,Priestnall SL,Sharma E,Goulart MR,Gribben J,Xia D,Garden OA

    更新日期：2019-09-17 00:00:00

  • The Replication-Transmission Relativity Theory for Multiscale Modelling of Infectious Disease Systems.

    abstract：:It is our contention that for multiscale modelling of infectious disease systems to evolve and expand in scope, it needs to be founded on a theory. Such a theory would improve our ability to describe infectious disease systems in terms of their scales and levels of organization, and their inter-relationships. In this ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52820-3

    authors： Garira W

    更新日期：2019-11-08 00:00:00

  • A framework for in situ molecular characterization of coral holobionts using nanopore sequencing.

    abstract：:Molecular characterization of the coral host and the microbial assemblages associated with it (referred to as the coral holobiont) is currently undertaken via marker gene sequencing. This requires bulky instruments and controlled laboratory conditions which are impractical for environmental experiments in remote areas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72589-0

    authors： Carradec Q,Poulain J,Boissin E,Hume BCC,Voolstra CR,Ziegler M,Engelen S,Cruaud C,Planes S,Wincker P

    更新日期：2020-09-28 00:00:00

  • Spatio-temporal dynamics of soil bacterial communities as a function of Amazon forest phenology.

    abstract：:Most tropical evergreen rain forests are characterised by varying degrees of precipitation seasonality that influence plant phenology and litterfall dynamics. Soil microbes are sensitive to soil water:air ratio and to nutrient availability. We studied if within-year seasonality in precipitation and litterfall-derived ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22380-z

    authors： Buscardo E,Geml J,Schmidt SK,Freitas H,da Cunha HB,Nagy L

    更新日期：2018-03-12 00:00:00

  • Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome.

    abstract：:Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, patterns in the traditional frequency domain (measured in Hz, or cycles per second) may capture different cardiac phenomena at different heart rates. An alternative is to consider freque...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34540

    authors： Liu Y,Scirica BM,Stultz CM,Guttag JV

    更新日期：2016-10-06 00:00:00

  • Comparison of efficacy and safety of conventional laparoscopic radical prostatectomy by the transperitoneal versus extraperitoneal procedure.

    abstract：:Worldwide, prostate cancer (PCa) is the second most common malignancy in males. We undertook a meta-analysis to compare the efficacy and safety of conventional laparoscopic radical prostatectomy with a transperitoneal (TLRP) approach, versus that of an extraperitoneal (ELRP) approach, for treatment of localized PCa. A...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep14442

    authors： De Hong C,Liang Ren L,Qiang W,Jia W,Ying Chun H,Lu Y,Zheng Hua L,Heng Ping L,Shi Bing Y,Yun Xiang L

    更新日期：2015-10-13 00:00:00

  • Interleukin-34 overexpression mediated through tumor necrosis factor-alpha reflects severity of synovitis in knee osteoarthritis.

    abstract：:This study aimed to investigate whether interleukin-34 (IL-34) mRNA expression is aberrant and modulated by tumor necrosis factor-alpha (TNF-α) in knee osteoarthritis (OA) fibroblast-like synoviocytes (FLS) and determine associations of IL-34 mRNA and protein in the systemic and local joint environments with severity ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64932-2

    authors： Udomsinprasert W,Jinawath A,Teerawattanapong N,Honsawek S

    更新日期：2020-05-14 00:00:00

  • Microstructure and chemical composition of Roman orichalcum coins emitted after the monetary reform of Augustus (23 B.C.).

    abstract：:A collection of ancient Roman orichalcum coins, i.e., a copper-zinc alloy, minted under the reigns from Caesar to Domitianus, have been characterised using scanning electron microscopy (SEM-EDS) and electron microprobe analysis (EMPA). We studied, for the first time, coins emitted by Romans after the reforms of August...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48941-4

    authors： Di Fazio M,Felici AC,Catalli F,De Vito C

    更新日期：2019-09-03 00:00:00

  • Alignment-free method for DNA sequence clustering using Fuzzy integral similarity.

    abstract：:A larger amount of sequence data in private and public databases produced by next-generation sequencing put new challenges due to limitation associated with the alignment-based method for sequence comparison. So, there is a high need for faster sequence analysis algorithms. In this study, we developed an alignment-fre...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40452-6

    authors： Saw AK,Raj G,Das M,Talukdar NC,Tripathy BC,Nandi S

    更新日期：2019-03-06 00:00:00

  • Approaching the strong coupling limit in single plasmonic nanorods interacting with J-aggregates.

    abstract：:We studied scattering and extinction of individual silver nanorods coupled to the J-aggregate form of the cyanine dye TDBC as a function of plasmon--exciton detuning. The measured single particle spectra exhibited a strongly suppressed scattering and extinction rate at wavelengths corresponding to the J-aggregate abso...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03074

    authors： Zengin G,Johansson G,Johansson P,Antosiewicz TJ,Käll M,Shegai T

    更新日期：2013-10-29 00:00:00

  • Optical observation of needles in upward lightning flashes.

    abstract：:Why lightning sometimes has multiple discharges to ground is an unanswered question. Recently, the observation of small plasma structures on positive leaders re-ignited the search. These small plasma structures were observed as pulsing radio sources along the positive leader length and were named "needles". Needles ma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74597-6

    authors： Saba MMF,de Paiva AR,Concollato LC,Warner TA,Schumann C

    更新日期：2020-10-15 00:00:00

  • Fibronectin synthesis, but not α-smooth muscle expression, is regulated by periostin in gingival healing through FAK/JNK signaling.

    abstract：:During skin healing, periostin facilitates myofibroblast differentiation through a β1 integrin/FAK dependent mechanism and continued expression is associated with scarring. In contrast to skin, gingival tissue does not typically scar upon injury, but the role of periostin in gingival healing has never been investigate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35805-6

    authors： Kim SS,Nikoloudaki GE,Michelsons S,Creber K,Hamilton DW

    更新日期：2019-02-25 00:00:00

  • Optimal SSSC-based power damping inter-area oscillations using firefly and harmony search algorithms.

    abstract：:The static synchronous series compensator (SSSC) can add a series reactance to the transmission line, and when it is fed using auxiliary signals, it can participate in damping inter-area oscillations by changing the series reactance. In this paper, the effect of the SSSC on small-signal stability is investigated. The ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69123-7

    authors： Naderipour A,Abdul-Malek Z,Ramachandaramurthy VK,Miveh MR,Moghaddam MJH,Guerrero JM

    更新日期：2020-07-22 00:00:00

  • Spectrochemical differentiation in gestational diabetes mellitus based on attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy and multivariate analysis.

    abstract：:Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75539-y

    authors： Bernardes-Oliveira E,de Freitas DLD,de Morais CLM,Cornetta MDCM,Camargo JDAS,de Lima KMG,Crispim JCO

    更新日期：2020-11-06 00:00:00

  • Aseismic transient during the 2010-2014 seismic swarm: evidence for longer recurrence of M ≥ 6.5 earthquakes in the Pollino gap (Southern Italy)?

    abstract：:In actively deforming regions, crustal deformation is accommodated by earthquakes and through a variety of transient aseismic phenomena. Here, we study the 2010-2014 Pollino (Southern Italy) swarm sequence (main shock M W 5.1) located within the Pollino seismic gap, by analysing the surface deformation derived from Gl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00649-z

    authors： Cheloni D,D'Agostino N,Selvaggi G,Avallone A,Fornaro G,Giuliani R,Reale D,Sansosti E,Tizzani P

    更新日期：2017-04-12 00:00:00

  • Amyloid-beta neuroprotection mediated by a targeted antioxidant.

    abstract：:Amyloid-beta (Aβ)-induced neurotoxicity is a major contributor to the pathologies associated with Alzheimer's disease (AD). The formation of reactive oxygen species (ROS), an early response induced by the peptide and oligomeric derivatives of Aβ, plays a significant role in effecting cellular pathogenesis. Here we emp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04983

    authors： Giordano CR,Terlecky LJ,Bollig-Fischer A,Walton PA,Terlecky SR

    更新日期：2014-05-15 00:00:00

  • Author Correction: Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-67913-7

    authors： Venkatesulu BP,Sharma A,Pollard-Larkin JM,Sadagopan R,Symons J,Neri S,Singh PK,Tailor R,Lin SH,Krishnan S

    更新日期：2020-06-30 00:00:00

  • SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.

    abstract：:The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be u...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10984

    authors： Akita M,Tak YS,Shimura T,Matsumoto S,Okuda-Shimizu Y,Shimizu Y,Nishi R,Saitoh H,Iwai S,Mori T,Ikura T,Sakai W,Hanaoka F,Sugasawa K

    更新日期：2015-06-04 00:00:00

  • Study of Conversion of Bio-oil Model Compounds in Supercritical Water Using Density Functional Theory.

    abstract：:It is well known that supercritical water is a favourable medium for biomass conversion followed by its hydrodeoxygenation (HDO). Moreover, the actual kinetics and mechanism of reaction occurring in the supercritical water are not yet completely understood, either by experimental or computational approaches. Within th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66237-w

    authors： Agrawal K,Kishore N

    更新日期：2020-06-08 00:00:00

  • Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology.

    abstract：:Renal fibrosis is one of the important pathways involved in end-stage renal failure. Investigating the metabolic changes in the progression of disease may enhance the understanding of its pathogenesis and therapeutic information. In this study, (1)H-nuclear magnetic resonance (NMR)-based metabonomics was firstly used ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27194

    authors： Zhao L,Dong M,Liao S,Du Y,Zhou Q,Zheng H,Chen M,Ji J,Gao H

    更新日期：2016-06-03 00:00:00

  • mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion.

    abstract：:mRNAs containing premature termination codons (PTCs) are rapidly degraded through nonsense-mediated mRNA decay (NMD). However, some PTC-containing mRNAs evade NMD, and might generate mutant proteins responsible for various diseases, including cancers. Using PTC-containing human genomic β-globin constructs, we show tha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16177-9

    authors： Kim WK,Yun S,Kwon Y,You KT,Shin N,Kim J,Kim H

    更新日期：2017-11-20 00:00:00

  • MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.

    abstract：:Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28281

    authors： Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

    更新日期：2016-09-06 00:00:00

  • Controlled electron injection facilitated by nanoparticles for laser wakefield acceleration.

    abstract：:We propose a novel injection scheme for laser-driven wakefield acceleration in which controllable localized electron injection is obtained by inserting nanoparticles into a plasma medium. The nanoparticles provide a very confined electric field that triggers localized electron injection where nonlinear plasma waves ar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34998-0

    authors： Cho MH,Pathak VB,Kim HT,Nam CH

    更新日期：2018-11-16 00:00:00

  • His-tag protein monitoring by a fast mix-and-measure immunoassay.

    abstract：:Here, we present a fast mix-and-measure immunoassay for the specific semiquantitative detection of His-tagged proteins, for example in E. coli cell lysate. The assay is based on Förster resonance energy transfer (FRET) between a lanthanide dye-labeled low-affinity His-peptide and an acceptor-labeled anti-His-tag antib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05613

    authors： Kreisig T,Prasse AA,Zscharnack K,Volke D,Zuchner T

    更新日期：2014-07-08 00:00:00

  • Vascular Remodelling Relates to an Elevated Oscillatory Shear Index and Relative Residence Time in Spontaneously Hypertensive Rats.

    abstract：:Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01906-x

    authors： Chen Z,Yu H,Shi Y,Zhu M,Wang Y,Hu X,Zhang Y,Chang Y,Xu M,Gao W

    更新日期：2017-05-17 00:00:00