Abstract：
:Affinity measure is a key factor that determines the quality of the analysis of a complex network. Here, we introduce a type of statistics, activation forces, to weight the links of a complex network and thereby develop a desired affinity measure. We show that the approach is superior in facilitating the analysis through experiments on a large-scale word network and a protein-protein interaction (PPI) network consisting of ∼5,000 human proteins. The experiment on the word network verifies that the measured word affinities are highly consistent with human knowledge. Further, the experiment on the PPI network verifies the measure and presents a general method for the identification of functionally similar proteins based on PPIs. Most strikingly, we find an affinity network that compactly connects the cancer-associated proteins to each other, which may reveal novel information for cancer study; this includes likely protein interactions and key proteins in cancer-related signal transduction pathways.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Guo J,Guo H,Wang Zdoi
10.1038/srep00113subject
Has Abstractpub_date
2011-01-01 00:00:00pages
113issn
2045-2322journal_volume
1pub_type
杂志文章abstract：:Adenosine-to-Inosine (A-to-I) RNA editing is the most prevalent post-transcriptional modification of RNA molecules. Researchers have attempted to find reliable RNA editing using next generation sequencing (NGS) data. However, most of these attempts suffered from a high rate of false positives, and they did not conside...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41294-y
更新日期：2019-03-25 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-61396-2
更新日期：2020-03-06 00:00:00
abstract：:The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00278-6
更新日期：2017-03-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01631-5
更新日期：2017-05-03 00:00:00
abstract：:The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve skin health. This work aims to characterize by a multidisciplinary approach, the wound healing, anti-inflammatory, anti-pathogens and proteomic effects of six LAB lysates, belonging to the genus Lactobacillus. Our resul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68483-4
更新日期：2020-07-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17961
更新日期：2015-12-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30384-y
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69688-3
更新日期：2020-07-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40026
更新日期：2017-01-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/srep39780
更新日期：2016-12-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16040
更新日期：2015-11-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13628-1
更新日期：2017-10-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27602-y
更新日期：2018-07-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59474-6
更新日期：2020-02-20 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-017-02141-0
更新日期：2017-05-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29727-6
更新日期：2018-07-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17089
更新日期：2015-11-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39666-5
更新日期：2019-03-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29745
更新日期：2016-07-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05207-1
更新日期：2017-07-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48720-1
更新日期：2019-08-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35473-6
更新日期：2018-11-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27643-3
更新日期：2018-07-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29866-w
更新日期：2018-07-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64747-1
更新日期：2020-05-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19618
更新日期：2016-01-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78131-6
更新日期：2020-12-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32310-8
更新日期：2018-09-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23634-6
更新日期：2018-03-28 00:00:00
