Abstract：
:Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR-TP53BP1, TMEM135-CCDC67, KDM4-AC011523.2 and LRRC59-FLJ60017) are less frequent. Both TRMT11-GRIK2 and CCNH-C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yu YP,Liu P,Nelson J,Hamilton RL,Bhargava R,Michalopoulos G,Chen Q,Zhang J,Ma D,Pennathur A,Luketich J,Nalesnik M,Tseng G,Luo JHdoi
10.1038/s41598-019-38550-6subject
Has Abstractpub_date
2019-01-31 00:00:00pages
1074issue
1issn
2045-2322pii
10.1038/s41598-019-38550-6journal_volume
9pub_type
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