Abstract:
:During folliculogenesis, primary oocytes of teleosts grow by several orders of magnitude by-self synthesizing proteins and mRNA, or sequestering from blood specific macromolecular components, such as fatty acids and vitellogenin. All these materials are stored into cortical alveoli, yolk globules or oil droplets during oocyte development. The proper synthesis, storage and displacement of these macromolecular components inside the oocyte play a key role for a successful fertilization process and for the subsequently correct embryo development. In this study, for the first time, the FTIR Imaging (FTIRI) spectroscopy has been applied to characterize the chemical building blocks of several cellular components of swordfish oocytes at different developmental stages. In particular, the spectral features of previtellogenic (PV), vitellogenic (VTG), mature (M) and atretic (A) follicles as well as and of cortical alveoli (CA), yolk vesicles (YV), oil droplets (OD) and Zona Radiata (ZR) have been outlined, providing new insights in terms of composition and topographical distribution of macromolecules of biological interest such as lipids, proteins, carbohydrates and phosphates. The macromolecular characterization of swordfish oocytes at different developmental stages represents a starting point and a useful tool for the assessment of swordfish egg quality caught in different conditions, such as periods of the year or different fishing area.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Carnevali O,Candelma M,Sagrati A,Pignalosa P,Giorgini E,Gioacchini Gdoi
10.1038/s41598-019-45065-7subject
Has Abstractpub_date
2019-06-20 00:00:00pages
8850issue
1issn
2045-2322pii
10.1038/s41598-019-45065-7journal_volume
9pub_type
杂志文章abstract::Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are several controversies concerning the role of H2S in cancer development and progression. In this study, we found that the growth and migration of hepatocellular carcinoma (HCC) cells were enhanced by 10-100 μM NaHS and dose-dependentl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05457-z
更新日期:2017-07-11 00:00:00
abstract::8p22-23-rs2254546 was firstly discovered to be associated with Kawasaki disease (KD) susceptibility by a genome-wide association study. However, only one Chinese replication study has been performed so far. To verify this association in another Chinese population, a hospital-based case-control study in Zhejiang provin...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep04247
更新日期:2014-02-28 00:00:00
abstract::Known γ-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identified as direct inhibitors of γ-secretase. To search for bioactive mol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16541
更新日期:2015-11-16 00:00:00
abstract::Spin injection, manipulation and detection are the integral parts of spintronics devices and have attracted tremendous attention in the last decade. It is necessary to judiciously choose the right combination of materials to have compatibility with the existing semiconductor technology. Conventional metallic magnets w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05588
更新日期:2014-07-07 00:00:00
abstract::The prediction of drug-target interactions is a key step in the drug discovery process, which serves to identify new drugs or novel targets for existing drugs. However, experimental methods for predicting drug-target interactions are expensive and time-consuming. Therefore, the in silico prediction of drug-target inte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13867
更新日期:2015-09-09 00:00:00
abstract::Long-term high-fat diet (HFD) consumption leads to not only obese-insulin resistance, but also impaired left ventricular (LV) function. Vagus nerve stimulation (VNS) has been shown to exert cardioprotection. However, its effects on the heart and metabolic parameters under obese-insulin resistant condition is not known...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19749
更新日期:2016-02-01 00:00:00
abstract::Transport of mesoscale particles due to driving flow fields or external forces on a periodic surface appears in many areas. Geometrical and physical characteristics of particles affect the velocities of the particles in these periodic landscapes. In this paper, we present a numerical simulation based on solving the La...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75187-2
更新日期:2020-10-26 00:00:00
abstract::Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy. The 111In-labelled DOTA-conjugated ZEGFR:2377 Affibody molecule was successfully used for imaging of EGFR-expressing xenografts in mice. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05700-7
更新日期:2017-07-20 00:00:00
abstract::This study aimed to define the width and length of the dental arch in 12-year-old Vietnamese children, and to elucidate differences between genders and among ethnic groups. A cross-sectional study was conducted in 4565 12 years-old children from the 4 major ethnic groups in Vietnam (Kinh, Muong, Thai, and Tay), with a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39710-4
更新日期:2019-02-28 00:00:00
abstract::Pragmatic theories of communication assume that humans evolved a species-unique inferential capacity to express and recognize intentions via communicative actions. We show that 13-month-old non-verbal infants can interpret the turn-taking exchange of variable tone sequences between unfamiliar agents as indicative of c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27804-4
更新日期:2018-06-22 00:00:00
abstract::Quantum cryptography is set to become a key technology for future secure communications. However, to get maximum benefit in communication networks, transmission links will need to be shared among several quantum keys for several independent users. Such links will enable switching in quantum network nodes of the quantu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12309-3
更新日期:2017-09-29 00:00:00
abstract::RFeO3 orthoferrites, where R is a rare-earth ion of the lanthanide series, are attracting attention mostly because of their promising fast spin dynamics. The magnetic properties of these materials seem to crucially depend on whether the magnetizations of the R and Fe ions' weak ferromagnetic (WFM) components are paral...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37529
更新日期:2016-11-25 00:00:00
abstract::For people with synaesthesia ordinary stimuli such as digits or letters induce concurrent experiences such as colours. Synaesthesia is associated with a memory advantage and the aim of this study was to investigate whether this advantage persists across time. We tested recognition memory of four different types of syn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60388-6
更新日期:2020-02-26 00:00:00
abstract::Satellite aerosol optical depth (AOD) is widely used to estimate particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5) mass concentrations. Polar orbiting satellite retrieval 1-2 times each day is frequently affected by cloud, snow cover or misclassification of heavy pollution. Novel methods are therefore requi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28535-2
更新日期:2018-07-05 00:00:00
abstract::Recent studies have shown that cellular metabolism plays an important role in regulating immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) cells and dendritic cells (DCs) exhibit increased glycolysis through the upregulation of glycolytic enzymes, such as hexokinase-2 (HK2)....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42412
更新日期:2017-02-10 00:00:00
abstract::Patient-matched transcriptomic studies using tumour samples before and after treatment allow inter-patient heterogeneity to be controlled, but tend not to include an untreated comparison. Here, Illumina BeadArray technology was used to measure dynamic changes in gene expression from thirty-seven paired diagnostic core...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29434
更新日期:2016-07-07 00:00:00
abstract::A highly sensitive microwave near-field sensor based on electrically-small planar resonators is proposed for highly accurate characterization of dielectric materials. The proposed sensor was developed in a robust complete-cycle topology optimization procedure wherein first the sensing area was pixelated. By maximizing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49767-w
更新日期:2019-09-16 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-28391-0
更新日期:2018-07-11 00:00:00
abstract::Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries. Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacterial growth. Optimization in the sulfolane series led to co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09642-y
更新日期:2017-08-25 00:00:00
abstract::Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27599-4
更新日期:2018-06-18 00:00:00
abstract::High-entropy alloys (HEAs) have inspired considerable interest due to their attractive physical and mechanical properties. In this work, the microstructural evolution induced by different heat treatments on rapidly solidified hypoeutectic precursors of a Fe26.7Co26.7Ni26.7Si8.9B11 HEA is investigated and correlated wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36464-3
更新日期:2019-01-23 00:00:00
abstract::The present study evaluates the potential of Sar gassum muticum (Sar) and Jan ia rubens (Jan) seaweeds for enhancing growth and mitigating soil-salinity in chickpea (Cicer arietinum L.). Under control conditions, Sar and Jan extracts improved chickpea growth which was attributed to their potential for increasing photo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07692-w
更新日期:2017-09-05 00:00:00
abstract::Platelet activation is an important event involved in the pathophysiological processes of the coagulation system. Clinical evidence has shown that platelets undergo distinctive pathological processes during sepsis. Unfortunately, how platelets physiologically respond to inflammation or sepsis is not well understood. I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23653
更新日期:2016-03-29 00:00:00
abstract::We performed an integrated analysis of the transcriptome and metabolome from purple (Pr) and normal cultivated varieties (CK) of Dendrobium officinale to gain insights into the regulatory networks associated with phenylpropanoid metabolism and to identify the key regulatory genes of pigmentation. Metabolite and transc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74789-0
更新日期:2020-10-19 00:00:00
abstract::Climate-driven environmental change and land-use change often interact in their impact on biodiversity, but these interactions have received little scientific attention. Here we study the effects of climate-driven environmental variation (i.e. vegetation greenness) and land-use (protected versus unprotected areas) on ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31344-2
更新日期:2018-08-29 00:00:00
abstract::Diagnosability is central to taxonomy as are type specimens which define taxa. New advances in technologies and the discovery of new informative traits must be matched with previous taxonomic decisions based on name-bearing type specimens. Consequently, the challenge of sequencing highly degraded DNA from historical t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42310-x
更新日期:2019-04-09 00:00:00
abstract::Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascular risk associated with diabetes is more marked for women, but an understanding of the role of diastolic dysfunction in female susceptibility to diabetic cardiomyopathy is lacking. To invest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20703-8
更新日期:2018-02-05 00:00:00
abstract::It is unclear whether N-acetylaspartate (NAA) depletions documented in schizophrenia patients might be due to the disease progression or medications. Here we investigated longitudinal NAA changes in drug-naïve first-episode patients (FEP) who are relatively free from chronicity. Forty-two drug-naïve FEP and 38 control...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09109
更新日期:2015-03-16 00:00:00
abstract::Microorganisms are key components for plant biomass breakdown within rumen environments. Fibrobacter succinogenes have been identified as being active and dominant cellulolytic members of the rumen. In this study, F. succinogenes type strain S85 was adapted for steady state growth in continuous culture at pH 5.75 and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02628-w
更新日期:2017-05-23 00:00:00
abstract::Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-term toxicities of such complexes, due in part to the speciation to van...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73539-6
更新日期:2020-10-07 00:00:00