Suppressive effect of exogenous carbon monoxide on endotoxin-stimulated platelet over-activation via the glycoprotein-mediated PI3K-Akt-GSK3β pathway.

abstract：:The mechanism of droplet drying is a widely concerned fundamental issue since controlling the deposition morphology of droplet has significant influence on printing, biology pattern, self-assembling and other solution-based devices fabrication. Here we reveal a striking different kinetics-controlled deposition regime ...

journal_title：Scientific reports

authors： Li Y,Yang Q,Li M,Song Y

更新日期：2016-04-19 00:00:00

abstract：:EEG is known to contain considerable inter-trial and inter-subject variability, which poses a challenge in any group-level EEG analyses. A true experimental effect must be reproducible even with variabilities in trials, sessions, and subjects. Extracting components that are reproducible across trials and subjects bene...

journal_title：Scientific reports

authors： Tanaka H

更新日期：2020-01-09 00:00:00

abstract：:Sweetness is one of the main drivers of consumer preference, and thus is given high priority in apple breeding programmes. Due to the complexity of sweetness evaluation, soluble solid content (SSC) is commonly used as an estimation of this trait. Nevertheless, it has been demonstrated that SSC and sweet taste are poor...

journal_title：Scientific reports

authors： Aprea E,Charles M,Endrizzi I,Laura Corollaro M,Betta E,Biasioli F,Gasperi F

更新日期：2017-03-21 00:00:00

abstract：:Most of the current studies on myocardial strain are mainly applied in patients with sinus rhythm because the image quality of arrhythmias obtained with conventional scanning sequences does not meet diagnostic needs. Here, we intend to assess left ventricular (LV) global myocardial strain in patients with arrhythmias ...

journal_title：Scientific reports

authors： Chen H,Xie RM,Zhao L,Zhang XY,Zhao YK,Wang Z,Xie GX,Ma XH

更新日期：2020-06-09 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are an important family of catalytic enzymes that generate reactive oxygen species (ROS), which mediate the regulation of diverse cellular functions. Although phagocyte Nox2/gp91phox is closely associated with the activation of host innate immune respo...

journal_title：Scientific reports

authors： Kim JH,Lee J,Bae SJ,Kim Y,Park BJ,Choi JW,Kwon J,Cha GH,Yoo HJ,Jo EK,Bae YS,Lee YH,Yuk JM

更新日期：2017-07-25 00:00:00

abstract：:A better understanding of the mechanisms of action of human adjuvants could inform a rational development of next generation vaccines for human use. Here, we exploited a genome wide transcriptomics analysis combined with a systems biology approach to determine the molecular signatures induced by four clinically tested...

journal_title：Scientific reports

authors： Olafsdottir TA,Lindqvist M,Nookaew I,Andersen P,Maertzdorf J,Persson J,Christensen D,Zhang Y,Anderson J,Khoomrung S,Sen P,Agger EM,Coler R,Carter D,Meinke A,Rappuoli R,Kaufmann SH,Reed SG,Harandi AM

更新日期：2016-12-13 00:00:00

abstract：:Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA re...

journal_title：Scientific reports

authors： Cho E,Kim DH,Hur YN,Whitcomb DJ,Regan P,Hong JH,Kim H,Ho Suh Y,Cho K,Park M

更新日期：2015-07-29 00:00:00

abstract：:Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs...

journal_title：Scientific reports

authors： Morettin A,Paris G,Bouzid Y,Baldwin RM,Falls TJ,Bell JC,Côté J

更新日期：2017-07-11 00:00:00

abstract：:Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker is available to reliably define eligibility criteria for a maintenance treatment with Li. We examined whether the prophylactic response to Li (assessed ret...

journal_title：Scientific reports

authors： Marie-Claire C,Lejeune FX,Mundwiller E,Ulveling D,Moszer I,Bellivier F,Etain B

更新日期：2020-07-22 00:00:00

abstract：:In March/April 2020 the Italian government drastically reduced vehicle traffic and interrupted all non-essential industrial activities over the entire national territory. Italy thus became the first country in the world, with the exception of Hubei, to enact lockdown measures as a consequence of the COVID-19 outbreak ...

journal_title：Scientific reports

authors： Poli P,Boaga J,Molinari I,Cascone V,Boschi L

更新日期：2020-06-10 00:00:00

abstract：:Potassium channel tetramerization domain containing 12 (KCTD12), the auxiliary GABAB receptor subunit, is identified as a susceptibility gene for bipolar I (BPI) disorder in the Han Chinese population. Moreover, the single-nucleotide polymorphism (SNP) rs17026688 in glutamate decarboxylase-like protein 1 (GADL1) is sh...

journal_title：Scientific reports

authors： Wu TN,Chen CK,Lee CS,Wu BJ,Sun HJ,Chang CH,Chen CY,Wu LS,Cheng AT

更新日期：2019-07-16 00:00:00

abstract：:Small RNA-Seq is a common means to interrogate the small RNA'ome or the full spectrum of small RNAs (<200 nucleotide length) of a biological system. A pivotal problem in NGS based small RNA analysis is identifying and quantifying the small RNA'ome constituent components. For example, small RNAs in the circulatory syst...

journal_title：Scientific reports

authors： Li J,Kho AT,Chase RP,Pantano L,Farnam L,Amr SS,Tantisira KG

更新日期：2020-03-12 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Carregari VC,Rosa-Fernandes L,Baldasso P,Bydlowski SP,Marangoni S,Larsen MR,Palmisano G

更新日期：2018-10-23 00:00:00

abstract：:MiR-204 and miR-211 (miR-204/211) share the same seed site sequence, targeting many of the same genes. Their role in cancer development remains controversial, as both cell proliferative and suppressive effects have been identified. This study aimed to address the relationship between the two structurally similar micro...

journal_title：Scientific reports

authors： Lee H,Lee S,Bae H,Kang HS,Kim SJ

更新日期：2016-04-28 00:00:00

abstract：:A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be reliably controlled via applied signals. These machines are powered by a muscle strip composed of differentiated skeletal myofibers in a matrix of natural proteins, in...

journal_title：Scientific reports

authors： Cvetkovic C,Ferrall-Fairbanks MC,Ko E,Grant L,Kong H,Platt MO,Bashir R

更新日期：2017-06-19 00:00:00

abstract：:Papain-like cysteine proteases (PLCPs) are a class of proteolytic enzymes involved in many plant processes. Compared with the extensive research in Arabidopsis thaliana, little is known in castor bean (Ricinus communis) and physic nut (Jatropha curcas), two Euphorbiaceous plants without any recent whole-genome duplica...

journal_title：Scientific reports

authors： Zou Z,Huang Q,Xie G,Yang L

更新日期：2018-01-10 00:00:00

abstract：:We propose a method to simulate spin models in trapped ions using a digital-analog approach, consisting in a suitable gate decomposition in terms of analog blocks and digital steps. In this way, we show that the quantum dynamics of an enhanced variety of spin models could be implemented with substantially less number ...

journal_title：Scientific reports

authors： Arrazola I,Pedernales JS,Lamata L,Solano E

更新日期：2016-07-29 00:00:00

abstract：:Chromobox 6 (CBX6) is a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epigenetic gene repression and acts as an oncogene or tumor suppressor in a cancer type-dependent manner. The specific function of CBX6 in breast cancer is currently undefined. In this study, a comprehensive analysis of The Cancer Ge...

journal_title：Scientific reports

authors： Deng H,Guan X,Gong L,Zeng J,Zhang H,Chen MY,Li G

更新日期：2019-01-17 00:00:00

abstract：:Beta amyloid peptides (Aβ) are known risk factors involved in cognitive impairment, neuroinflammatory and apoptotic processes in Alzheimer's disease (AD). Phosphodiesterase 2 (PDE2) inhibitors increase the intracellular cAMP and/or cGMP activities, which may ameliorate cognitive deficits associated with AD. However, i...

journal_title：Scientific reports

authors： Wang L,Xiaokaiti Y,Wang G,Xu X,Chen L,Huang X,Liu L,Pan J,Hu S,Chen Z,Xu Y

更新日期：2017-09-21 00:00:00

abstract：:Osteopontin (OPN), a multifunctional cytokine that controls liver glycerolipid metabolism, is involved in activation and proliferation of several liver cell types during regeneration, a condition of high metabolic demands. Here we investigated the role of OPN in modulating the liver lipidome during regeneration after ...

journal_title：Scientific reports

authors： Nuñez-Garcia M,Gomez-Santos B,Saenz de Urturi D,Mestre D,Gonzalez-Romero F,Buque X,Gutiérrez-de Juan V,Martinez-Chantar ML,Syn WK,Fresnedo O,Aspichueta P

更新日期：2018-10-02 00:00:00

abstract：:Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activ...

journal_title：Scientific reports

authors： Lee TY,Chang CC,Lu WJ,Yen TL,Lin KH,Geraldine P,Li JY,Sheu JR

更新日期：2017-01-05 00:00:00

abstract：:Tendons must be able to withstand the forces generated by muscles and not fail. Accordingly, a previous comparative analysis across species has shown that tendon strength (i.e., failure stress) increases for larger species. In addition, the elastic modulus increases proportionally to the strength, demonstrating that t...

journal_title：Scientific reports

authors： Javidi M,McGowan CP,Schiele NR,Lin DC

更新日期：2019-06-03 00:00:00

abstract：:The Law of the Minimum is often implemented using t-norm or fuzzy intersection. We propose the use of t-conorm or fuzzy union for climate suitability assessment of a grass species using annual ryegrass (Lolium multiflorum Lam.) as an example and evaluate the performance for alfalfa (Medicago sativa L.) and sorghum (So...

journal_title：Scientific reports

authors： Kim H,Hyun SW,Hoogenboom G,Porter CH,Kim KS

更新日期：2018-07-05 00:00:00

abstract：:A potted experiment with Populus × euramericana 'Neva' was carried out to assess whether there are positive effects of magnetic treatment of saline water (MTSW) on nitrogen metabolism under controlled conditions in a greenhouse. Growth properties, nitrogen contents, enzyme activities and metabolite concentrations were...

journal_title：Scientific reports

authors： Liu X,Zhu H,Wang L,Bi S,Zhang Z,Meng S,Zhang Y,Wang H,Song C,Ma F

更新日期：2019-07-11 00:00:00

abstract：:The simplest and most commonly used acoustic levitator is comprised of a transmitter and an opposing reflecting surface. This type of device, however, is only able to levitate objects along one direction, at distances multiple of half of a wavelength. In this work, we show how a customised reflective acoustic metamate...

journal_title：Scientific reports

authors： Polychronopoulos S,Memoli G

更新日期：2020-03-06 00:00:00

abstract：:The biliary tree is an essential component of transplantable human liver tissue. Despite recent advances in liver tissue engineering, attempts at re-creating the intrahepatic biliary tree have not progressed significantly. The finer branches of the biliary tree are structurally and functionally complex and heterogeneo...

journal_title：Scientific reports

authors： Lewis PL,Su J,Yan M,Meng F,Glaser SS,Alpini GD,Green RM,Sosa-Pineda B,Shah RN

更新日期：2018-08-15 00:00:00

abstract：:IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates. Forty-three isolates were observed to carry IncX4 type plasmid, among which 13 were identified to carry mcr-1 ...

journal_title：Scientific reports

authors： Sun J,Fang LX,Wu Z,Deng H,Yang RS,Li XP,Li SM,Liao XP,Feng Y,Liu YH

更新日期：2017-03-24 00:00:00

abstract：:We present detailed investigations on single crystals of quaternary EuRhAl4Si2 and EuIrAl4Si2. The two compounds order antiferromagnetically at TN1 = 11.7 and 14.7 K, respectively, each undergoing two magnetic transitions. The magnetic properties in the ordered state present a large anisotropy despite Eu(2+)being an S...

journal_title：Scientific reports

authors： Maurya A,Thamizhavel A,Dhar SK,Bonville P

更新日期：2015-07-09 00:00:00

abstract：:Intense geomagnetic storms can cause severe damage to electrical systems and communications. This work proposes a counting process with Weibull inter-occurrence times in order to estimate the probability of extreme geomagnetic events. It is found that the scale parameter of the inter-occurrence time distribution grows...

journal_title：Scientific reports

authors： Moriña D,Serra I,Puig P,Corral Á

更新日期：2019-02-20 00:00:00

abstract：:Previous studies highlight the winners and losers in fisheries under climate change based on shifts in biomass, species composition and potential catches. Understanding how climate change is likely to alter the fisheries revenues of maritime countries is a crucial next step towards the development of effective socio-e...

journal_title：Scientific reports

authors： Lam VW,Cheung WW,Reygondeau G,Sumaila UR

更新日期：2016-09-07 00:00:00