Abstract：
:Hypoxia is a recognized characteristic of tumors that influences efficacy of radiotherapy (RT). Photoacoustic imaging (PAI) is a relatively new imaging technique that exploits the optical characteristics of hemoglobin to provide information on tissue oxygenation. In the present study, PAI based measures of tumor oxygen saturation (%sO2) were compared to oxygen-enhanced magnetic resonance imaging (MRI) measurements of longitudinal relaxation rate (R1 = 1/T1) and ex-vivo histology in patient derived xenograft (PDX) models of head and neck cancer. PAI was utilized to assess early changes (24 h) in %sO2 following RT and chemoRT (CRT) and to assess changes in salivary gland hemodynamics following radiation. A significant increase in tumor %sO2 and R1 was observed following oxygen inhalation. Good spatial correlation was observed between PAI, MRI and histology. An early increase in %sO2 after RT and CRT detected by PAI was associated with significant tumor growth inhibition. Twenty four hours after RT, PAI also detected loss of hemodynamic response to gustatory stimulation in murine salivary gland tissue suggestive of radiation-induced vascular damage. Our observations illustrate the utility of PAI in detecting tumor and normal tissue hemodynamic response to radiation in head and neck cancers.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rich LJ,Seshadri Mdoi
10.1038/srep21237subject
Has Abstractpub_date
2016-02-17 00:00:00pages
21237issn
2045-2322pii
srep21237journal_volume
6pub_type
杂志文章abstract：:The Irish Travellers are a population with a history of nomadism; consanguineous unions are common and they are socially isolated from the surrounding, 'settled' Irish people. Low-resolution genetic analysis suggests a common Irish origin between the settled and the Traveller populations. What is not known, however, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42187
更新日期：2017-02-09 00:00:00
abstract：:The occurrence of toxic metals in the aquatic environment is as caused by a variety of contaminations which makes difficulty in the concentration prediction. In this study, conventional methods of back-propagation neural network (BPNN) and nonlinear autoregressive network with exogenous inputs (NARX) were applied as b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70438-8
更新日期：2020-08-10 00:00:00
abstract：:There is a growing interest concerning the relevance of salivary cortisone levels in stress-related research. However, studies investigating morning patterns and day-to-day variability of cortisone versus cortisol levels are lacking. Cortisol and cortisone analysis by liquid chromatography-tandem mass spectroscopy (LC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55571-3
更新日期：2019-12-17 00:00:00
abstract：:A relevant part of embolic strokes of undetermined source (ESUS) is assumed to be cardiogenic. As shown previously, certain biomarkers of endothelial pathology are related to atrial fibrillation (AF). In this long-term follow-up study, we aimed to investigate whether these biomarkers are associated with subsequently d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55943-9
更新日期：2019-12-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53365-1
更新日期：2019-11-14 00:00:00
abstract：:From the viewpoint of networks, a ranking system for players or teams in sports is equivalent to a centrality measure for sports networks, whereby a directed link represents the result of a single game. Previously proposed network-based ranking systems are derived from static networks, i.e., aggregation of the results...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00904
更新日期：2012-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33867
更新日期：2016-09-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-12-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38161
更新日期：2016-12-02 00:00:00
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pub_type： 杂志文章
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更新日期：2017-08-15 00:00:00
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pub_type： 杂志文章
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更新日期：2017-08-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40263-9
更新日期：2019-03-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20713-6
更新日期：2018-02-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37635
更新日期：2016-11-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41008-4
更新日期：2019-03-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-05-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33745-9
更新日期：2018-10-22 00:00:00
abstract：:This paper has been retracted. ...
journal_title：Scientific reports
pub_type： 已发布勘误,撤回出版物
doi：10.1038/s41598-019-44557-w
更新日期：2019-06-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07351-0
更新日期：2017-08-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58607-1
更新日期：2020-02-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50140-0
更新日期：2019-09-23 00:00:00
abstract：:Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41131
更新日期：2017-01-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80005-w
更新日期：2021-01-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36564-0
更新日期：2019-01-24 00:00:00
abstract：:Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured. Thus, culture conditions, which enhance the maintenance of chondrocyte phenotype would be very useful for cartilage research...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03958-5
更新日期：2017-06-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06146-7
更新日期：2017-07-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72241-x
更新日期：2020-09-16 00:00:00
abstract：:Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maint...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02638-8
更新日期：2017-06-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45311-y
更新日期：2019-06-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06216-w
更新日期：2017-07-19 00:00:00
