CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current.

abstract：:Since the spring 2018, a large part of Europe has been in the midst of a record-setting drought. Using long-term observations, we demonstrate that the occurrence of the 2018-2019 (consecutive) summer drought is unprecedented in the last 250 years, and its combined impact on the growing season vegetation activities is ...

journal_title：Scientific reports

authors： Hari V,Rakovec O,Markonis Y,Hanel M,Kumar R

更新日期：2020-08-06 00:00:00

abstract：:Efficient mitochondrial Ca2+ uptake takes place at contact points between the ER and mitochondria, and represents a key regulator of many cell functions. In a previous study with HeLa cells, we showed that ER-to-mitochondria Ca2+ transfer increases during the early phase of ER stress induced by tunicamycin as an adapt...

journal_title：Scientific reports

authors： Bravo-Sagua R,López-Crisosto C,Parra V,Rodriguez-Peña M,Rothermel BA,Quest AF,Lavandero S

更新日期：2016-11-03 00:00:00

abstract：:Breast tissue heterogeneity is related to risk factors that lead to more aggressive tumour growth and worse prognosis, yet such heterogeneity has not been well characterized. The aim of this study is to reveal the heterogeneous signal patterns of the apparent diffusion coefficient (ADC) of a tumour and its surrounding...

journal_title：Scientific reports

authors： Fan M,He T,Zhang P,Zhang J,Li L

更新日期：2017-06-06 00:00:00

abstract：:Upper lip scars are at risk of hypertrophy. Our center therefore uses microporous tape and silicone sheeting for postoperative scar care following cleft lip repair. However, some babies have previously ingested their silicone sheeting, which has the potential for respiratory compromise or gastrointestinal obstruction....

journal_title：Scientific reports

authors： Chang CS,Wallace CG,Hsiao YC,Huang JJ,Chen ZC,Chang CJ,Lo LJ,Chen PK,Chen JP,Chen YR

更新日期：2018-05-09 00:00:00

abstract：:Common features of immune-metabolic and inflammatory diseases such as metabolic syndrome, diabetes, obesity and cardiovascular diseases are an altered gut microbiota composition and a systemic pro-inflammatory state. We demonstrate that active immunization against the outer membrane protein of bacteria present in the ...

journal_title：Scientific reports

authors： Saita D,Ferrarese R,Foglieni C,Esposito A,Canu T,Perani L,Ceresola ER,Visconti L,Burioni R,Clementi M,Canducci F

更新日期：2016-07-07 00:00:00

abstract：:The aperture stop of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual image: the "entrance pupil" of the eye. When viewed off-axis, the entrance pupil has an elliptical form. The precise appearance of the entrance pupil is a consequence of the anatomical and optical properti...

journal_title：Scientific reports

authors： Aguirre GK

更新日期：2019-06-27 00:00:00

abstract：:The ability of Treponema pallidum, the syphilis spirochete to colonize various tissues requires the presence of surface-exposed adhesins that have been difficult to identify due to the inability to culture and genetically manipulate T. pallidum. Using a Borrelia burgdorferi-based heterologous system and gain-in-functi...

journal_title：Scientific reports

authors： Chan K,Nasereddin T,Alter L,Centurion-Lara A,Giacani L,Parveen N

更新日期：2016-05-10 00:00:00

abstract：:In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wil...

journal_title：Scientific reports

authors： Ito H,Udono T,Hirata S,Inoue-Murayama M

更新日期：2018-07-03 00:00:00

abstract：:We study a system of active particles with soft repulsive interactions that lead to an active cluster-crystal phase in two dimensions. We use two different modelizations of the active force - Active Brownian particles (ABP) and Ornstein-Uhlenbeck particles (AOUP) - and focus on analogies and differences between them. ...

journal_title：Scientific reports

authors： Caprini L,Hernández-García E,López C,Marini Bettolo Marconi U

更新日期：2019-11-13 00:00:00

abstract：:The favourable kinetics of 18F-fluoro-2-deoxyglucose (FDG) permits to depict cancer glucose consumption by a single evaluation of late tracer uptake. This standard procedure relies on the slow radioactivity loss, usually attributed to the limited tumour expression of G6P-phosphatase (G6Pase). However, this classical i...

journal_title：Scientific reports

authors： Scussolini M,Bauckneht M,Cossu V,Bruno S,Orengo AM,Piccioli P,Capitanio S,Yosifov N,Ravera S,Morbelli S,Piana M,Sambuceti G,Caviglia G,Marini C

更新日期：2019-02-26 00:00:00

abstract：:Mitochondria act as a platform for antiviral innate immunity, and the immune system depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) signaling pathway via an adaptor molecule, mitochondrial antiviral signaling. We report that RLR-mediated antiviral innate immunity requires oxida...

journal_title：Scientific reports

authors： Yoshizumi T,Imamura H,Taku T,Kuroki T,Kawaguchi A,Ishikawa K,Nakada K,Koshiba T

更新日期：2017-07-14 00:00:00

abstract：:3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate the e...

journal_title：Scientific reports

authors： Kang LJ,Oh E,Cho C,Kwon H,Lee CG,Jeon J,Lee H,Choi S,Han SJ,Nam J,Song CU,Jung H,Kim HY,Park EJ,Choi EJ,Kim J,Eyun SI,Yang S

更新日期：2020-03-27 00:00:00

abstract：:The nuclear pore complex (NPC) is one of the largest supramolecular structures in eukaryotic cells. Its octagonal ring-scaffold perforates the nuclear envelope and features a unique molecular machinery that regulates nucleocytoplasmic transport. NPCs are composed of ~30 different nucleoporins (Nups), averaged at 8, 16...

journal_title：Scientific reports

authors： Mi L,Goryaynov A,Lindquist A,Rexach M,Yang W

更新日期：2015-03-23 00:00:00

abstract：:Still recently, bacterial fluid suspensions have motivated a lot of works, both experimental and theoretical, with the objective to understand their collective dynamics from universal and simple rules. Since some species are active, most of these works concern the strong interactions that these bacteria exert on a for...

journal_title：Scientific reports

authors： Ben Amar M

更新日期：2016-02-18 00:00:00

abstract：:Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is used as a first-line treatment for advanced non-small cell lung cancer (NSCLC). However, most NSCLC patients inevitably develop gefitinib resistance, and the mechanisms underlying this resistance are not fully understood. In this study...

journal_title：Scientific reports

authors： Cao X,Lai S,Hu F,Li G,Wang G,Luo X,Fu X,Hu J

更新日期：2017-06-07 00:00:00

abstract：:Early detection of breast cancer and its correct stage determination are important for prognosis and rendering appropriate personalized clinical treatment to breast cancer patients. However, despite considerable efforts and progress, there is a need to identify the specific genomic factors responsible for, or accompan...

journal_title：Scientific reports

authors： Roy S,Kumar R,Mittal V,Gupta D

更新日期：2020-03-05 00:00:00

abstract：:Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as...

journal_title：Scientific reports

authors： Preez GD,Fourie H,Daneel M,Miller H,Höss S,Ricci C,Engelbrecht G,Zouhar M,Wepener V

更新日期：2020-03-06 00:00:00

abstract：:Combined neutron scattering and diffusion nuclear magnetic resonance experiments have been used to reveal significant interregional asymmetries (lateralization) in bovine brain hemispheres in terms of myelin arrangement and water dynamics at micron to atomic scales. Thicker myelin sheaths were found in the left hemisp...

journal_title：Scientific reports

authors： Natali F,Dolce C,Peters J,Stelletta C,Demé B,Ollivier J,Leduc G,Cupane A,Barbier EL

更新日期：2019-10-11 00:00:00

abstract：:We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed...

journal_title：Scientific reports

authors： Dugas LR,Bernabé BP,Priyadarshini M,Fei N,Park SJ,Brown L,Plange-Rhule J,Nelson D,Toh EC,Gao X,Dong Q,Sun J,Kliethermes S,Gottel N,Luke A,Gilbert JA,Layden BT

更新日期：2018-11-20 00:00:00

abstract：:Diabetes is a chronic metabolic disease that causes blood glucose (BG) concentration to make dangerous excursions outside its physiological range. Measuring the fraction of time spent by BG outside this range, and, specifically, the time-below-range (TBR), is a clinically common way to quantify the effectiveness of th...

journal_title：Scientific reports

authors： Camerlingo N,Vettoretti M,Facchinetti A,Sparacino G,Mader JK,Choudhary P,Del Favero S

更新日期：2020-10-23 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： de Genaro IS,de Almeida FM,Hizume-Kunzler DC,Moriya HT,Silva RA,Cruz JCG,Lopes RB,Righetti RF,de Paula Vieira R,Saiki M,Martins MA,Tibério IFLC,Arantes-Costa FM,Saraiva-Romanholo BM

更新日期：2018-12-12 00:00:00

abstract：:During maternal recognition of pregnancy (MRP), a conceptus-derived signal leads to the persistence of the corpus luteum and the maintenance of gestation. In the horse, the nature of this signal remains to be elucidated. Several studies have focused on the changes in gene expression during MRP, but little information ...

journal_title：Scientific reports

authors： Smits K,Willems S,Van Steendam K,Van De Velde M,De Lange V,Ververs C,Roels K,Govaere J,Van Nieuwerburgh F,Peelman L,Deforce D,Van Soom A

更新日期：2018-03-27 00:00:00

abstract：:Time-series metabolomics studies can provide insight into the dynamics of disease development and facilitate the discovery of prospective biomarkers. To improve the performance of early risk identification, a new strategy for analyzing time-series data based on dynamic networks (ATSD-DN) in a systematic time dimension...

journal_title：Scientific reports

authors： Huang X,Zeng J,Zhou L,Hu C,Yin P,Lin X

更新日期：2016-08-31 00:00:00

abstract：:Iron is an essential mineral required for most forms of life. However, very little is known in relation to the different forms of dietary iron on the development of NAFLD. The aims of this study were to investigate the effects of iron intake from different food types on risk of NAFLD and whether this effect may be mod...

journal_title：Scientific reports

authors： Peng XE,Xu SH,Liu W,Hu Z,Lin Z,Lin X

更新日期：2019-03-11 00:00:00

abstract：:The role of orbital differentiation on the emergence of superconductivity in the Fe-based superconductors remains an open question to the scientific community. In this investigation, we employ a suitable microscopic spin probe technique, namely Electron Spin Resonance (ESR), to investigate this issue on selected chemi...

journal_title：Scientific reports

authors： Rosa PF,Adriano C,Garitezi TM,Grant T,Fisk Z,Urbano RR,Pagliuso PG

更新日期：2014-10-08 00:00:00

abstract：:Tendons must be able to withstand the forces generated by muscles and not fail. Accordingly, a previous comparative analysis across species has shown that tendon strength (i.e., failure stress) increases for larger species. In addition, the elastic modulus increases proportionally to the strength, demonstrating that t...

journal_title：Scientific reports

authors： Javidi M,McGowan CP,Schiele NR,Lin DC

更新日期：2019-06-03 00:00:00

abstract：:We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and...

journal_title：Scientific reports

authors： Yoon J,Lee M,Lee K,Kim N,Kim JM,Park J,Yu H,Choi C,Heo WD,Park Y

更新日期：2015-08-21 00:00:00

abstract：:Recent research shows that continuous overgrazing not only causes grassland biodiversity to decline, but also causes light fungal disease. Achnatherum inebrians is susceptible to fungal diseases and increases in prevalence during over grazing due its toxicity to livestock. This study aimed to examine the effects of A....

journal_title：Scientific reports

authors： Yao X,Fan Y,Chai Q,Johnson RD,Nan Z,Li C

更新日期：2016-09-16 00:00:00

abstract：:Plasma free amino acid (PFAA) profile is highlighted in its association with visceral obesity and hyperinsulinemia, and future diabetes. Indeed PFAA profiling potentially can evaluate individuals' future risks of developing lifestyle-related diseases, in addition to diabetes. However, few studies have been performed e...

journal_title：Scientific reports

authors： Yamakado M,Nagao K,Imaizumi A,Tani M,Toda A,Tanaka T,Jinzu H,Miyano H,Yamamoto H,Daimon T,Horimoto K,Ishizaka Y

更新日期：2015-07-09 00:00:00

abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

journal_title：Scientific reports

authors： Alsaran H,Elkhadragy L,Shakya A,Long W

更新日期：2017-11-03 00:00:00