Flow-induced platelet activation in components of the extracorporeal membrane oxygenation circuit.

abstract：:The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However, CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents, despite the evidence that vulnerability for many psychiatric disorders accumulates during early life. Here, we assessed...

journal_title：Scientific reports

authors： Sequeira-Cordero A,Salas-Bastos A,Fornaguera J,Brenes JC

更新日期：2019-11-22 00:00:00

abstract：:The brain is a paradigmatic example of a complex system: its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the functional architecture of the brain in terms of links (correlations) between nodes (grey matter regions) and to extract ...

journal_title：Scientific reports

authors： Mastrandrea R,Gabrielli A,Piras F,Spalletta G,Caldarelli G,Gili T

更新日期：2017-07-07 00:00:00

abstract：:The foregut endoderm gives rise to several organs including liver, pancreas, lung and thyroid with important roles in human physiology. Understanding which genes and signalling pathways regulate their development is crucial for understanding developmental disorders as well as diseases in adulthood. We exploited unique...

journal_title：Scientific reports

authors： Trubiroha A,Gillotay P,Giusti N,Gacquer D,Libert F,Lefort A,Haerlingen B,De Deken X,Opitz R,Costagliola S

更新日期：2018-04-04 00:00:00

abstract：:Changes in litterfall dynamics and soil properties due to anthropogenic or natural perturbations have important implications to soil carbon (C) and nutrient cycling via microbial pathway. Here we determine soil microbial responses to contrasting types of litter inputs (leaf vs. fine woody litter) and nitrogen (N) depo...

journal_title：Scientific reports

authors： Sun XL,Zhao J,You YM,Jianxin Sun O

更新日期：2016-01-14 00:00:00

abstract：:Omega-3 fatty acids, and specifically docosahexaenoic acid (DHA), are important and essential nutrients for human health. Thraustochytrids are recognised as commercial strains for nutraceuticals production, they are group of marine oleaginous microorganisms capable of co-synthesis of DHA and other valuable carotenoids...

journal_title：Scientific reports

authors： Patel A,Liefeldt S,Rova U,Christakopoulos P,Matsakas L

更新日期：2020-02-06 00:00:00

abstract：:Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the failure of normal glucose-stimulated insulin secretion (GSIS) from p...

journal_title：Scientific reports

authors： Davey JS,Carmichael RE,Craig TJ

更新日期：2019-02-27 00:00:00

abstract：:A retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals ...

journal_title：Scientific reports

authors： Headley SA,Oliveira TES,Pereira AHT,Moreira JR,Michelazzo MMZ,Pires BG,Marutani VHB,Xavier AAC,Di Santis GW,Garcia JL,Alfieri AA

更新日期：2018-09-07 00:00:00

abstract：:Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full ...

journal_title：Scientific reports

authors： Zhang M,Zhang X,Xu K,Teng Q,Liu Q,Li X,Yang J,Xu J,Chen H,Zhang X,Li Z

更新日期：2016-09-28 00:00:00

abstract：:Deregulated expression of microRNAs has been associated with angiogenesis. Studying the miRNome of locally advanced breast tumors we unsuspectedly found a dramatically repression of miR-204, a small non-coding RNA with no previous involvement in tumor angiogenesis. Downregulation of miR-204 was confirmed in an indepen...

journal_title：Scientific reports

authors： Flores-Pérez A,Marchat LA,Rodríguez-Cuevas S,Bautista-Piña V,Hidalgo-Miranda A,Ocampo EA,Martínez MS,Palma-Flores C,Fonseca-Sánchez MA,Astudillo-de la Vega H,Ruíz-García E,González-Barrios JA,Pérez-Plasencia C,Streber ML,Lópe

更新日期：2016-10-05 00:00:00

abstract：:Identification of loci or genes under natural selection is important for both understanding the genetic basis of local adaptation and practical applications, and genome scans provide a powerful means for such identification purposes. In this study, genome-wide simple sequence repeats markers (SSRs) were used to scan f...

journal_title：Scientific reports

authors： Song Z,Zhang M,Li F,Weng Q,Zhou C,Li M,Li J,Huang H,Mo X,Gan S

更新日期：2016-10-17 00:00:00

abstract：:Perivascular spaces (PVSs) in brain have a close relationship with typical neurological diseases. The quantitative studies of PVSs are meaningful but usually difficult, due to their thin and weak signals and also background noise in the 7 T brain magnetic resonance images (MRI). To clearly distinguish the PVSs in the ...

journal_title：Scientific reports

authors： Hou Y,Park SH,Wang Q,Zhang J,Zong X,Lin W,Shen D

更新日期：2017-08-17 00:00:00

abstract：:Lassa virus (LASV) is the causative agent of Lassa fever (LF), an often-fatal hemorrhagic disease. LF is endemic in Nigeria, Sierra Leone and other West African countries. Diagnosis of LASV infection is challenged by the genetic diversity of the virus, which is greatest in Nigeria. The ReLASV Pan-Lassa Antigen Rapid T...

journal_title：Scientific reports

authors： Boisen ML,Uyigue E,Aiyepada J,Siddle KJ,Oestereich L,Nelson DKS,Bush DJ,Rowland MM,Heinrich ML,Eromon P,Kayode AT,Odia I,Adomeh DI,Muoebonam EB,Akhilomen P,Okonofua G,Osiemi B,Omoregie O,Airende M,Agbukor J,Ehikha

更新日期：2020-05-26 00:00:00

abstract：:Due to their small dimensions, electrophysiology on thin and intricate axonal branches in support of understanding their role in normal and diseased brain function poses experimental challenges. To reduce experimental complexity, we coupled microelectrode arrays (MEAs) to bi-level microchannel devices for the long-ter...

journal_title：Scientific reports

authors： Habibey R,Latifi S,Mousavi H,Pesce M,Arab-Tehrany E,Blau A

更新日期：2017-08-17 00:00:00

abstract：:In the eyeblink conditioning paradigm, cerebellar Purkinje cells learn to respond to the conditional stimulus with an adaptively timed pause in its spontaneous firing. Evidence suggests that the pause is elicited by glutamate released from parallel fibers and acting on metabotropic receptors (mGluR7) which initiates a...

journal_title：Scientific reports

authors： Johansson F,Hesslow G

更新日期：2020-09-24 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Kustov S,Liubimova I,Corró M,Torrens-Serra J,Wang X,Haines CRS,Salje EKH

更新日期：2019-07-24 00:00:00

abstract：:The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving combinatorial ECM arrays seemed intuitively advantageous. We propose an alternative that suggests reducing sample size and technological burd...

journal_title：Scientific reports

authors： Jung JP,Hu D,Domian IJ,Ogle BM

更新日期：2015-12-21 00:00:00

abstract：:The capture and activation of individual T cells on functionalised surfaces enables real-time analyses of the magnitude and rhythm of intracellular calcium release. Application of Haarlet transformations generate a calcium flux 'threshold', with the frequency of the 'threshold crossings' correlating with the strength ...

journal_title：Scientific reports

authors： Christo SN,Diener KR,Nordon RE,Brown MP,Griesser HJ,Vasilev K,Christo FC,Hayball JD

更新日期：2015-01-14 00:00:00

abstract：:This multi-disciplinary work provides an updated assessment of possible future eruptive scenarios for the city of Rome. Seven new 40Ar/39Ar ages from selected products of the Monti Sabatini and Vulsini volcanic districts, along with a compilation of all the literature ages on the Colli Albani and Vico products, are us...

journal_title：Scientific reports

authors： Marra F,Castellano C,Cucci L,Florindo F,Gaeta M,Jicha BR,Palladino DM,Sottili G,Tertulliani A,Tolomei C

更新日期：2020-05-26 00:00:00

abstract：:Heterotrimeric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs. However, some non-receptor proteins are also GEFs. GIV (a.k.a Girdin) was the first non-receptor protein for which the GEF activity was ascribed to a well-defined protein sequence that directly binds Gαi....

journal_title：Scientific reports

authors： DiGiacomo V,de Opakua AI,Papakonstantinou MP,Nguyen LT,Merino N,Blanco-Canosa JB,Blanco FJ,Garcia-Marcos M

更新日期：2017-08-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Liang G,Ai Q,Yu D

更新日期：2020-04-20 00:00:00

abstract：:The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolac...

journal_title：Scientific reports

authors： Xu R,Zhao H,Muhammad H,Dong M,Besenbacher F,Chen M

更新日期：2017-08-17 00:00:00

abstract：:Seeds of tomato were magnetoprimed at 100 mT for 30 min followed by imbibition for 12 and 24 h, respectively, at 20 °C, to examine the biochemical and molecular changes involved in homeostasis of hydrogen peroxide (H2O2) and its signaling associated with hormone interactions for promoting vigor. The relative transcrip...

journal_title：Scientific reports

authors： Anand A,Kumari A,Thakur M,Koul A

更新日期：2019-06-19 00:00:00

abstract：:Discovered in 1813, the conoscopic interference pattern observed due to light propagating through a crystal, kept between crossed polarizers, shows isochromates and isogyres, respectively containing information about the dynamic and geometric phase acquired by the beam. We propose and demonstrate a closed-fringe Fouri...

journal_title：Scientific reports

authors： Samlan CT,Naik DN,Viswanathan NK

更新日期：2016-09-14 00:00:00

abstract：:Ring-opening graft polymerization (ROGP) of L-Lactide (L-LA) is a practical method of altering the physical and chemical properties of lignocellulose. Previous studies have mainly investigated cellulose and tin-based catalysts, particularly of tin(II) 2-ethylhexanoate (Sn(oct)2), at high temperatures and reported low ...

journal_title：Scientific reports

authors： Zhang X,Wang H,Liu C,Zhang A,Ren J

更新日期：2017-04-03 00:00:00

abstract：:Integrin alpha-4 (ITGA4) is a validated therapeutic target for multiple sclerosis (MS) and Natalizumab, an antibody targeting ITGA4 is currently approved for treating MS. However, there are severe side effects related to this therapy. In this study, we report the development of a novel DNAzyme that can efficiently cle...

journal_title：Scientific reports

authors： Chakravarthy M,Aung-Htut MT,Le BT,Veedu RN

更新日期：2017-05-09 00:00:00

abstract：:An ultrasensitive DNA biosensor has been developed through in-situ labeling of electroactive melamine-Cu(2+) complex (Mel-Cu(2+)) on the end of hairpin-like probe using gold nanoparticles (AuNPs) as the signal amplification platform. The 3'-thiolated hairpin-like probe was first immobilized to the gold electrode surfa...

journal_title：Scientific reports

authors： Wang Q,Gao F,Ni J,Liao X,Zhang X,Lin Z

更新日期：2016-03-02 00:00:00

abstract：:To improve the performance of solar photovoltaic devices one should mitigate three types of losses: optical, electrical and thermal. However, further reducing the optical and electrical losses in modern photovoltaic devices is becoming increasingly costly. Therefore, there is a rising interest in minimizing the therma...

journal_title：Scientific reports

authors： Vaillon R,Dupré O,Cal RB,Calaf M

更新日期：2018-09-03 00:00:00

abstract：:Continuous and non-invasive monitoring of hemodynamic parameters through unobtrusive wearable sensors can potentially aid in early detection of cardiac abnormalities, and provides a viable solution for long-term follow-up of patients with chronic cardiovascular diseases without disrupting the daily life activities. El...

journal_title：Scientific reports

authors： Shafiq G,Tatinati S,Ang WT,Veluvolu KC

更新日期：2016-11-22 00:00:00

abstract：:The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human umbilical vein endothelial cells (HUVEC) and differentiated neutrophil...

journal_title：Scientific reports

authors： Swamynathan S,Tiwari A,Loughner CL,Gnalian J,Alexander N,Jhanji V,Swamynathan SK

更新日期：2019-04-11 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. PPAR agonists have well-documented anti-inflammatory and neuroprotective roles in the central nervous system. Recent evidence suggests that PPAR agonists are attractive therapeutic agen...

journal_title：Scientific reports

authors： Warden A,Truitt J,Merriman M,Ponomareva O,Jameson K,Ferguson LB,Mayfield RD,Harris RA

更新日期：2016-06-10 00:00:00