Bending behavior of biomimetic scale covered beam with tunable stiffness scales.

abstract：:Tetrandrine (Tet) could enhance the antitumor effect of Paclitaxel (Ptx) by increasing intracellular Reactive Oxygen Species (ROS) levels, which leads to the possibility of co-delivery of both drugs for synergistic antitumor effect. In the current study, we reported an efficient, local therapeutic strategy employing e...

journal_title：Scientific reports

authors： Zhang H,Tian Y,Zhu Z,Xu H,Li X,Zheng D,Sun W

更新日期：2016-05-26 00:00:00

abstract：:Despite the quintessential role that music plays in human societies by enabling us to release and share emotions with others, traces of its evolutionary origins in other species remain scarce. Drumming like humans whilst producing music is practically unheard of in our most closely related species, the great apes. Alt...

journal_title：Scientific reports

authors： Dufour V,Poulin N,Charlotte Curé,Sterck EH

更新日期：2015-06-17 00:00:00

abstract：:Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing colorectal cancer (CRC) in humans. However, little is known about the role of vitamin D binding protein (VDBP) in colorectal carcinogenesis. Blood...

journal_title：Scientific reports

authors： Ying HQ,Sun HL,He BS,Pan YQ,Wang F,Deng QW,Chen J,Liu X,Wang SK

更新日期：2015-01-22 00:00:00

abstract：:Outer membrane vesicles (OMVs) produced by Gram-negative bacteria have roles in cell-to-cell signaling, biofilm formation, and stress responses. Here, the effects of abiotic stressors on OMV contents and composition from biofilm cells of the plant health-promoting bacterium Pseudomonas chlororaphis O6 (PcO6) are exami...

journal_title：Scientific reports

authors： Potter M,Hanson C,Anderson AJ,Vargis E,Britt DW

更新日期：2020-12-04 00:00:00

abstract：:Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the r...

journal_title：Scientific reports

authors： Zhao L,Li J,Ma Y,Wang J,Pan W,Gao K,Zhang Z,Lu T,Ruan Y,Yue W,Zhao S,Wang L,Zhang D

更新日期：2015-10-26 00:00:00

abstract：:Archeological researches have proposed arguments for human mobility and long-distance trading over the Eurasia before the Silk Roads. Here we utilize biologically available strontium isotope analysis to assess the extent of pre-Silk Road population movements and cultural communications across the Asian interior. From ...

journal_title：Scientific reports

authors： Wang X,Tang Z,Wu J,Wu X,Wu Y,Zhou X

更新日期：2016-10-20 00:00:00

abstract：:Fishes in the mesopelagic zone (200-1000 m) have recently been highlighted for potential exploitation. Here we assess global phylogeography in Maurolicus, the Pearlsides, an ecologically important group. We obtained new sequences from mitochondrial COI and nuclear ITS-2 from multiple locations worldwide, representing ...

journal_title：Scientific reports

authors： Rees DJ,Poulsen JY,Sutton TT,Costa PAS,Landaeta MF

更新日期：2020-11-25 00:00:00

abstract：:Breast cancer survivors are more likely to develop mood disorders and cognitive deficits than women in the general population. Previous studies suggest that peripheral tumors elicit central pro-inflammatory cytokine production, in turn leading to depression and cognitive deficits. In the current study, two cohorts of ...

journal_title：Scientific reports

authors： Walker Ii WH,Borniger JC,Surbhi,Zalenski AA,Muscarella SL,Fitzgerald JA,Zhang N,Gaudier-Diaz MM,DeVries AC

更新日期：2017-08-15 00:00:00

abstract：:The occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing phenomenon named metabolic memory. In this study, we show that a kidney pathway is gradually altered during the course of diabetes and remains persistently cha...

journal_title：Scientific reports

authors： de Oliveira AA,de Oliveira TF,Bobadilla LL,Garcia CC,Berra CM,de Souza-Pinto NC,Medeiros MH,Di Mascio P,Zatz R,de M Loureiro AP

更新日期：2017-01-12 00:00:00

abstract：:Attosecond (asec) X-ray free-electron laser (XFEL) has attracted considerable interest over the past years. Nowadays typical XFEL application experiments demand 1010-1011 photons per pulse, which corresponds to a peak power of terawatts (TW) in case of asec hard X-ray pulse. To the realization of such TW asec-XFEL pul...

journal_title：Scientific reports

authors： Shim CH,Parc YW,Kim DE

更新日期：2020-01-28 00:00:00

abstract：:Porphyry systems supply most copper and significant gold to our economy. Recent studies indicate that they are frequently associated with high Sr/Y magmatic rocks, but the meaning of this association remains elusive. Understanding the association between high Sr/Y magmatic rocks and porphyry-type deposits is essential...

journal_title：Scientific reports

authors： Chiaradia M,Ulianov A,Kouzmanov K,Beate B

更新日期：2012-01-01 00:00:00

abstract：:We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 ...

journal_title：Scientific reports

authors： Jia Z,Huang X,Wu H,Zhang T,Li N,Ding P,Sun Y,Liu Z,Wei F,Zhang H,Jiao Y,Ji Y,Zhang Y,Guo C,Li W,Mou D,Xia W,Li Z,Chen D,Yan H,Chen X,Zhao J,Meyers K,Cohen T,Mayer K,Salomon JA,Lu Z,Dye C

更新日期：2015-07-02 00:00:00

abstract：:Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study aimed to distinguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in combination with GNPs. DNA dam...

journal_title：Scientific reports

authors： Ghita M,McMahon SJ,Taggart LE,Butterworth KT,Schettino G,Prise KM

更新日期：2017-03-16 00:00:00

abstract：:Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the diversity of molecular changes that occur in these tissues may guide the development of ...

journal_title：Scientific reports

authors： Hamilton PJ,Chen EY,Tolstikov V,Peña CJ,Picone JA,Shah P,Panagopoulos K,Strat AN,Walker DM,Lorsch ZS,Robinson HL,Mervosh NL,Kiraly DD,Sarangarajan R,Narain NR,Kiebish MA,Nestler EJ

更新日期：2020-10-22 00:00:00

abstract：:Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg). ASS1 is silenced in many human malignancies therefore, these tumors require extracellular Arg for growth. The Arg-degrading recombinant protein, pegylated arginine deiminase (ADI-PEG20), has been in clinical trials fo...

journal_title：Scientific reports

authors： Tsai WB,Long Y,Chang JT,Savaraj N,Feun LG,Jung M,Chen HHW,Kuo MT

更新日期：2017-09-07 00:00:00

abstract：:The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject of active research for the past three decades. Although discrete evidence exists on various aspects of FXIII activation and regulation a combinatorial structure/functional view in this regard is lacking. In this study, we pre...

journal_title：Scientific reports

authors： Gupta S,Biswas A,Akhter MS,Krettler C,Reinhart C,Dodt J,Reuter A,Philippou H,Ivaskevicius V,Oldenburg J

更新日期：2016-07-25 00:00:00

abstract：:A significant advantage of a graphene biosensor is that it inherently represents a continuum of independent and aligned sensor-units. We demonstrate a nanoscale version of a micro-physiometer - a device that measures cellular metabolic activity from the local acidification rate. Graphene functions as a matrix of indep...

journal_title：Scientific reports

authors： Paulus GL,Nelson JT,Lee KY,Wang QH,Reuel NF,Grassbaugh BR,Kruss S,Landry MP,Kang JW,Vander Ende E,Zhang J,Mu B,Dasari RR,Opel CF,Wittrup KD,Strano MS

更新日期：2014-10-31 00:00:00

abstract：:The Transient Receptor Potential vanilloid 4 ion channel (TRPV4) is an important sensor for osmotic and mechanical stimuli in the musculoskeletal system, and it is also involved in processes of nociception. In this study we investigated the putative role of TRPV4 ion channels in joint pain. In anesthetized rats we rec...

journal_title：Scientific reports

authors： Richter F,Segond von Banchet G,Schaible HG

更新日期：2019-07-29 00:00:00

abstract：:The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specific transcription. We...

journal_title：Scientific reports

authors： Hume DA,Wollscheid-Lengeling E,Rojo R,Pridans C

更新日期：2017-12-07 00:00:00

abstract：:Hepatic fibrosis is caused by exaggerated wound healing response to chronic injury, which eventually leads to hepatic cirrhosis. Differentiation of hepatic stellate cells (HSCs) to myofibroblast-like cells by inflammatory cytokines is the critical step in fibrosis. This step is accompanied by enlargement of the endopl...

journal_title：Scientific reports

authors： Tomoishi S,Fukushima S,Shinohara K,Katada T,Saito K

更新日期：2017-08-11 00:00:00

abstract：:Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking advantage of the metabolic flexibility of TNBC MDA-MB-231 cells to generate subpopulations with glycolytic or oxidative p...

journal_title：Scientific reports

authors： Urra FA,Muñoz F,Córdova-Delgado M,Ramírez MP,Peña-Ahumada B,Rios M,Cruz P,Ahumada-Castro U,Bustos G,Silva-Pavez E,Pulgar R,Morales D,Varela D,Millas-Vargas JP,Retamal E,Ramírez-Rodríguez O,Pessoa-Mahana H,Pavani M,Fer

更新日期：2018-09-04 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is sometimes mistaken for fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and fibroadenoma, and to ev...

journal_title：Scientific reports

authors： Lee SE,Han K,Kwak JY,Lee E,Kim EK

更新日期：2018-09-10 00:00:00

abstract：:Sodefrin, a decapeptide isolated from the male dorsal gland of the Japanese fire belly newt Cynops pyrrhogaster, was the first peptide pheromone identified from a vertebrate. The fire belly salamander and sodefrin have become a model for sex pheromone investigation in aquatically courting salamanders ever since. Subse...

journal_title：Scientific reports

authors： Van Bocxlaer I,Maex M,Treer D,Janssenswillen S,Janssens R,Vandebergh W,Proost P,Bossuyt F

更新日期：2016-03-03 00:00:00

abstract：:The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of whi...

journal_title：Scientific reports

authors： Okimoto K,Maruoka D,Matsumura T,Tokunaga M,Kaneko T,Oura H,Akizue N,Ohta Y,Saito K,Arai M,Kato J,Kato N

更新日期：2020-11-26 00:00:00

abstract：:We have demonstrated a 45 μm core diameter Neodymium-doped all-solid silicate glass photonic crystal fiber laser with a single mode laser output. The structure parameters and modes information of the fiber are both demonstrated by theoretical calculations using Finite Difference Time Domain (FDTD) method and experimen...

journal_title：Scientific reports

authors： Li W,Chen D,Qinling Z,Hu L

更新日期：2015-07-24 00:00:00

abstract：:Cassava is an important staple crop in tropical and sub-tropical areas. As a common farming practice, cassava is usually cultivated intercropping with other crops and subjected to various degrees of shading, which causes reduced productivity. Herein, a comparative transcriptomic analysis was performed on a series of d...

journal_title：Scientific reports

authors： Ding Z,Zhang Y,Xiao Y,Liu F,Wang M,Zhu X,Liu P,Sun Q,Wang W,Peng M,Brutnell T,Li P

更新日期：2016-08-19 00:00:00

abstract：:Altered neural mechanisms are well-acknowledged in irritable bowel syndrome (IBS), a disorder of brain-gut-communication highly comorbid with anxiety and depression. As a key hub in corticolimbic inhibition, medial prefrontal cortex (mPFC) may be involved in disturbed emotion regulation in IBS. However, aberrant mPFC ...

journal_title：Scientific reports

authors： Icenhour A,Tapper S,Bednarska O,Witt ST,Tisell A,Lundberg P,Elsenbruch S,Walter S

更新日期：2019-09-19 00:00:00

abstract：:In a 250-kyr transient simulation of the Community Earth System Model (CESM), we identified a precessional forced seesaw of the summer middle-upper tropospheric eddy temperature between Asia and the North Pacific as the paleo-APO (Asian-Pacific oscillation). The paleo-APO variability is out of phase with the precessio...

journal_title：Scientific reports

authors： Wang Y,Jian Z,Zhao P,Xiao D,Chen J

更新日期：2016-07-06 00:00:00

abstract：:Medulloblastoma (MB), the most common malignant paediatric brain tumour occurs in the cerebellum. Advances in molecular genomics have led to the identification of defined subgroups which are associated with distinct clinical prognoses. Despite this classification, standard therapies for all subgroups often leave child...

journal_title：Scientific reports

authors： Mather RL,Loveson KF,Fillmore HL

更新日期：2019-06-13 00:00:00

abstract：:HCV NS3 protein plays a central role in viral polyprotein processing and RNA replication. We demonstrate that the NS3 protease (NS3(pro)) domain alone can specifically bind to HCV-IRES RNA, predominantly in the SLIV region. The cleavage activity of the NS3 protease domain is reduced upon HCV-RNA binding. More importan...

journal_title：Scientific reports

authors： Ray U,Das S

更新日期：2011-01-01 00:00:00