Abstract：
:Resistin, an adipokine involved in insulin resistance (IR) and diabetes, has recently been reported to play a role in cardiovascular events. However, its effect on blood pressure (BP) and the underlying mechanisms remain unclear. In the present study, we showed that resistin induces hypertension and IR in wild type (WT) mice, but not in tlr4(-/-) mice. Resistin upregulated angiotensinogen (Agt) expression in WT mice, whereas it had no effect on tlr4(-/-) mice, or in mice treated with the angiotensin-converting enzyme inhibitor perindopril. Real-time PCR and chromatin immunoprecipitation further confirmed that resistin activates the renin-angiotensin system (RAS) via the TLR4/P65/Agt pathway. This finding suggested an essential role of resistin in linking IR and hypertension, which may offer a novel target in clinic on the study of the association between diabetes and hypertension.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jiang Y,Lu L,Hu Y,Li Q,An C,Yu X,Shu L,Chen A,Niu C,Zhou L,Yang Zdoi
10.1038/srep22193subject
Has Abstractpub_date
2016-02-26 00:00:00pages
22193issn
2045-2322pii
srep22193journal_volume
6pub_type
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