A Systematic Study of the Impact of Estrogens and Selective Estrogen Receptor Modulators on Prostate Cancer Cell Proliferation.

abstract：:The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala...

journal_title：Scientific reports

authors： Hakamata Y,Komi S,Moriguchi Y,Izawa S,Motomura Y,Sato E,Mizukami S,Kim Y,Hanakawa T,Inoue Y,Tagaya H

更新日期：2017-08-16 00:00:00

abstract：:The emergence of single-cell RNA sequencing (scRNA-seq) technologies has enabled us to measure the expression levels of thousands of genes at single-cell resolution. However, insufficient quantities of starting RNA in the individual cells cause significant dropout events, introducing a large number of zero counts in t...

journal_title：Scientific reports

authors： Talwar D,Mongia A,Sengupta D,Majumdar A

更新日期：2018-11-05 00:00:00

abstract：:Post-glycosylphosphatidylinositol (GPI) attachment to proteins 3, also known as PGAP3 or PERLD1 (PER1-like domain-containing protein 1), participates in the lipid remodeling process of glycosylphosphatidylinositol (GPI) anchor proteins during post-translational modification. Functional defect in PERLD1 was previously ...

journal_title：Scientific reports

authors： Sio YY,Anantharaman R,Lee SQE,Matta SA,Ng YT,Chew FT

更新日期：2020-01-20 00:00:00

abstract：:For scanning x-ray microscopy, many attempts have been made to image the phase contrast based on a concept of the beam being deflected by a specimen, the so-called differential phase contrast imaging (DPC). Despite the successful demonstration in a number of representative cases at moderate spatial resolutions, these ...

journal_title：Scientific reports

authors： Yan H,Chu YS,Maser J,Nazaretski E,Kim J,Kang HC,Lombardo JJ,Chiu WK

更新日期：2013-01-01 00:00:00

abstract：:In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic...

journal_title：Scientific reports

authors： Agoston-Coldea L,Lupu S,Mocan T

更新日期：2018-09-27 00:00:00

abstract：:Honeybee pupae morphology can be affected by a number of stressor, but in vivo investigation is difficult. A computed tomography (CT) technique was applied to visualize a comb's inner structure without damaging the brood. The CT scan was performed on a brood comb containing pupae developed from eggs laid by the queen ...

journal_title：Scientific reports

authors： Facchini E,Nalon L,Andreis ME,Di Giancamillo M,Rizzi R,Mortarino M

更新日期：2019-07-23 00:00:00

abstract：:Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellul...

journal_title：Scientific reports

authors： Bomfim LM,de Araujo FA,Dias RB,Sales CBS,Rocha CAG,Correa RS,Soares MBP,Batista AA,Bezerra DP

更新日期：2019-08-07 00:00:00

abstract：:Early-life social experiences cause lasting changes in behavior and health for a variety of animals including humans, but it is not well understood how social information ''gets under the skin'' resulting in these effects. Adult honey bees (Apis mellifera) exhibit socially coordinated collective nest defense, providin...

journal_title：Scientific reports

authors： Rittschof CC,Coombs CB,Frazier M,Grozinger CM,Robinson GE

更新日期：2015-10-23 00:00:00

abstract：:Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allo...

journal_title：Scientific reports

authors： Ma T,Peng Y,Huang W,Ding J

更新日期：2017-01-18 00:00:00

abstract：:We have proposed and successfully demonstrated a novel approach to direct conversion of mechanical energy into electrical energy using microfluidics. The method combines previously demonstrated reverse electrowetting on dielectric (REWOD) phenomenon with the fast self-oscillating process of bubble growth and collapse....

journal_title：Scientific reports

authors： Hsu TH,Manakasettharn S,Taylor JA,Krupenkin T

更新日期：2015-11-16 00:00:00

abstract：:Regulatory T cells (Tregs) expand in peripheral lymphoid organs and can produce immunosuppressive cytokines to support tumor growth. IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 and Th17 immunity. These effects are associ...

journal_title：Scientific reports

authors： Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

更新日期：2016-04-14 00:00:00

abstract：:There are a number of psychological phenomena in which dramatic emotional responses are evoked by seemingly innocuous perceptual stimuli. A well known example is the 'uncanny valley' effect whereby a near human-looking artifact can trigger feelings of eeriness and repulsion. Although such phenomena are reasonably well...

journal_title：Scientific reports

authors： Moore RK

更新日期：2012-01-01 00:00:00

abstract：:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...

journal_title：Scientific reports

authors： Shen ML,Wang CH,Lin CH,Zhou N,Kao ST,Wu DC

更新日期：2016-09-06 00:00:00

abstract：:Cartilage repair in osteoarthritic patients remains a challenge. Identifying resident or donor stem/progenitor cell populations is crucial for augmenting the low intrinsic repair potential of hyaline cartilage. Furthermore, mediating the interaction between these cells and the local immunogenic environment is thought ...

journal_title：Scientific reports

authors： Bauza G,Pasto A,Mcculloch P,Lintner D,Brozovich A,Niclot FB,Khan I,Francis LW,Tasciotti E,Taraballi F

更新日期：2020-10-06 00:00:00

abstract：:Lignosus rhinocerotis (Tiger milk mushroom) is an important folk medicine for indigenous peoples in Southeast Asia. We previously reported its de novo assembled 34.3 Mb genome encoding a repertoire of proteins including a putative bioactive fungal immunomodulatory protein. Here we report the cDNA of this new member (F...

journal_title：Scientific reports

authors： Pushparajah V,Fatima A,Chong CH,Gambule TZ,Chan CJ,Ng ST,Tan CS,Fung SY,Lee SS,Tan NH,Lim RL

更新日期：2016-07-27 00:00:00

abstract：:The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC),...

journal_title：Scientific reports

authors： Yang L,Luo D,Li L,Zhao Y,Lin M,Guo W,Zhou C

更新日期：2016-08-08 00:00:00

abstract：:The dependences of spreading and differentiation of stem cells plated on hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently been a subject of some controversy. In experiments on human mesenchymal stem cells plated on soft, medium rigidity, and hard silicone gels we show t...

journal_title：Scientific reports

authors： Vertelov G,Gutierrez E,Lee SA,Ronan E,Groisman A,Tkachenko E

更新日期：2016-09-21 00:00:00

abstract：:Campylobacter hyointestinalis is a member of an emerging group of zoonotic Campylobacter spp. that are increasingly identified in both gastric and non-gastric disease in humans. Here, we discovered C. hyointestinalis in three separate classes of New Zealand ruminant livestock; cattle, sheep and deer. To investigate th...

journal_title：Scientific reports

authors： Wilkinson DA,O'Donnell AJ,Akhter RN,Fayaz A,Mack HJ,Rogers LE,Biggs PJ,French NP,Midwinter AC

更新日期：2018-02-05 00:00:00

abstract：:Membrane proteins are key elements in cell-mediated processes. In particular, G protein-coupled receptors (GPCRs) have attracted increasing interest since they affect cellular signaling. Furthermore, mutations in GPCRs can cause acquired and inheritable diseases. Up to date, there still exist a number of GPCRs that ha...

journal_title：Scientific reports

authors： Zemella A,Grossmann S,Sachse R,Sonnabend A,Schaefer M,Kubick S

更新日期：2017-06-16 00:00:00

abstract：:In this study we present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. Texture analysis based on first-order statistics (FOS) and second-order statistics such as gray level co-occurrence matrix (GLCM) was explored to...

journal_title：Scientific reports

authors： Mostaço-Guidolin LB,Ko AC,Wang F,Xiang B,Hewko M,Tian G,Major A,Shiomi M,Sowa MG

更新日期：2013-01-01 00:00:00

abstract：:Sexual spores are important for the dispersal and population dynamics of fungi. They show remarkable morphological diversity, but the underlying forces driving spore evolution are poorly known. We investigated whether trophic status and substrate associations are associated with morphology in 787 macrofungal genera. W...

journal_title：Scientific reports

authors： Calhim S,Halme P,Petersen JH,Læssøe T,Bässler C,Heilmann-Clausen J

更新日期：2018-03-29 00:00:00

abstract：:Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, with peritoneal metastasis being the prevalent form of recurrence and metastasis in advanced disease. Currently, there are limited clinical ap...

journal_title：Scientific reports

authors： Zhang J,Huang JY,Chen YN,Yuan F,Zhang H,Yan FH,Wang MJ,Wang G,Su M,Lu G,Huang Y,Dai H,Ji J,Zhang J,Zhang JN,Jiang YN,Chen SJ,Zhu ZG,Yu YY

更新日期：2015-09-02 00:00:00

abstract：:The expansion of agriculture is shrinking pristine forest areas worldwide, jeopardizing the persistence of their wild inhabitants. The Udzungwa red colobus monkey (Procolobus gordonorum) is among the most threatened primate species in Africa. Primarily arboreal and highly sensitive to hunting and habitat destruction, ...

journal_title：Scientific reports

authors： Barelli C,Albanese D,Donati C,Pindo M,Dallago C,Rovero F,Cavalieri D,Tuohy KM,Hauffe HC,De Filippo C

更新日期：2015-10-07 00:00:00

abstract：:Efficient inactivation of Escherichia coli (E. coli) under visible (532 nm) pulsed light irradiation was achieved by fusion of a visible light-absorbing dye with E. coli. Inactivation experiments showed that 3-log inactivation of E. coli was obtained within 20 min under a 50 kJ/cm2 dose. This treatment time and dose m...

journal_title：Scientific reports

authors： Kohmura Y,Igami N,Tatsuno I,Hasegawa T,Matsumoto T

更新日期：2020-10-20 00:00:00

abstract：:Antibodies of the IgG class to terminal Galα3Gal (IgG anti-αGal) is abundant in human plasma and are reported to bind most sepsis-causing Gram-negative bacteria. However, these seminal findings, made more than two decades ago, have not been reexamined. Our aim was to assess IgG anti-αGal´s pathogen reactivity. We affi...

journal_title：Scientific reports

authors： Bernth Jensen JM,Petersen MS,Ellerman-Eriksen S,Møller BK,Jensenius JC,Sørensen UBS,Thiel S

更新日期：2020-03-12 00:00:00

abstract：:We report a method to promote photoluminescence emission in graphene materials by enhancing carrier scattering instead of directly modifying band structure in multilayer reduced graphene oxide (rGO) nanospheres. We intentionally curl graphene layers to form nanospheres by reducing graphene oxide with spherical polymer...

journal_title：Scientific reports

authors： Chen Q,Zhang C,Xue F,Zhou Y,Li W,Wang Y,Tu W,Zou Z,Wang X,Xiao M

更新日期：2013-01-01 00:00:00

abstract：:Diagnostic test accuracy of the loop-mediated isothermal amplification (LAMP) assay for culture proven tuberculosis is unclear. We searched electronic databases for both cohort and case-control studies that provided data to calculate sensitivity and specificity. The index test was any LAMP assay including both commerc...

journal_title：Scientific reports

authors： Nagai K,Horita N,Yamamoto M,Tsukahara T,Nagakura H,Tashiro K,Shibata Y,Watanabe H,Nakashima K,Ushio R,Ikeda M,Narita A,Kanai A,Sato T,Kaneko T

更新日期：2016-12-13 00:00:00

abstract：:Sludge bulking is a major problem that restricts the development of the activated sludge process. The microbial community responsible for sludge bulking varies depending on water quality and operational conditions. This study analysed the microbial community of bulking sludge in oxidation ditch with ultra-low sludge l...

journal_title：Scientific reports

authors： Zhang M,Yao J,Wang X,Hong Y,Chen Y

更新日期：2019-09-23 00:00:00

abstract：:Electrical contacts on the top surface of solar cells and light emitting diodes cause shadow losses. The phenomenon of extraordinary optical transmission through arrays of subwavelength holes suggests the possibility of engineering such contacts to reduce the shadow using plasmonics, but resonance effects occur only a...

journal_title：Scientific reports

authors： San Román E,Vitrey A,Buencuerpo J,Prieto I,Llorens JM,García-Martín A,Alén B,Chaudhuri A,Neumann A,Brueck SR,Ripalda JM

更新日期：2016-06-24 00:00:00

abstract：:Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physicall...

journal_title：Scientific reports

authors： Watabe M,Kato TA,Tsuboi S,Ishikawa K,Hashiya K,Monji A,Utsumi H,Kanba S

更新日期：2013-01-01 00:00:00