Abstract：
:Salivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS A146T and Q61H mutations in 2 out of 4 (50%) sarcomatoid SDC variants. Transgenic mice carrying the human oncogenic KRAS(G12V), which spatiotemporal activation by tamoxifen (TAM)-inducible Cre recombinase Ela-CreERT in the submandibular gland (SMG) ductal cells, was established and characterized. Visible carcinoma was detected as early as day-15 following oncogenic KRAS(G12V) induction alone, and these tumors proliferate rapidly with a median survival of 28-days accompanied with histological reminiscences to human sarcomatoid SDC variants. Moreover, these tumors were resistant to cetuximab treatment despite augmented EGFR signaling, attesting its malignancy. Our findings suggest that LGL-KRas(G12V);Ela-CreERT transgenic mice could serve as a useful preclinical model for investigating underlying mechanisms and developing potential therapies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fu Y,Cruz-Monserrate Z,Helen Lin H,Chung Y,Ji B,Lin SM,Vonderfecht S,Logsdon CD,Li CF,Ann DKdoi
10.1038/srep13347subject
Has Abstractpub_date
2015-08-20 00:00:00pages
13347issn
2045-2322pii
srep13347journal_volume
5pub_type
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